Self-experience in the early phases of schizophrenia: 5-year follow-up of the Copenhagen Prodromal Study

Josef Parnas; Andrea Raballo; Peter Handest; Lennart Jansson; Anne Vollmer-Larsen; Ditte Saebye

Self-experience in the early phases of schizophrenia: 5-year follow-up of the Copenhagen Prodromal Study

Josef Parnas, Andrea Raballo, Peter Handest, Lennart Jansson, Anne Vollmer-Larsen, Ditte Saebye

103 Citations (Scopus)

Abstract

Despite the avalanche of empirical data on prodroma/"at risk" conditions, the essential aspects of the vulnerability to the schizophrenia spectrum remain largely unaddressed. We report here the results of the Copenhagen Schizophrenia Prodromal Study, a prospective, observational study of first admission patients in putative state of beginning psychosis (N=151) with a follow-up length of 60 months. At follow-up, the rate of conversion to schizophrenia spectrum diagnosis was 37%, whereas the conversion rate from schizotypal disorder to schizophrenia was 25%. High levels of perplexity and self-disorders baseline scores yielded the best prediction of the subsequent development of schizophrenia spectrum disorders. Escalating transitions within the spectrum (i.e., from schizotypal disorder to schizophrenia) were not associated to any candidate psychopathological predictor.

Original language	English
Journal	World Psychiatry
Volume	10
Issue number	3
Pages (from-to)	200-4
Number of pages	5
ISSN	1723-8617
Publication status	Published - 1 Oct 2011

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AU - Parnas, Josef

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AU - Handest, Peter

AU - Jansson, Lennart

AU - Vollmer-Larsen, Anne

AU - Saebye, Ditte

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N2 - Despite the avalanche of empirical data on prodroma/"at risk" conditions, the essential aspects of the vulnerability to the schizophrenia spectrum remain largely unaddressed. We report here the results of the Copenhagen Schizophrenia Prodromal Study, a prospective, observational study of first admission patients in putative state of beginning psychosis (N=151) with a follow-up length of 60 months. At follow-up, the rate of conversion to schizophrenia spectrum diagnosis was 37%, whereas the conversion rate from schizotypal disorder to schizophrenia was 25%. High levels of perplexity and self-disorders baseline scores yielded the best prediction of the subsequent development of schizophrenia spectrum disorders. Escalating transitions within the spectrum (i.e., from schizotypal disorder to schizophrenia) were not associated to any candidate psychopathological predictor.

AB - Despite the avalanche of empirical data on prodroma/"at risk" conditions, the essential aspects of the vulnerability to the schizophrenia spectrum remain largely unaddressed. We report here the results of the Copenhagen Schizophrenia Prodromal Study, a prospective, observational study of first admission patients in putative state of beginning psychosis (N=151) with a follow-up length of 60 months. At follow-up, the rate of conversion to schizophrenia spectrum diagnosis was 37%, whereas the conversion rate from schizotypal disorder to schizophrenia was 25%. High levels of perplexity and self-disorders baseline scores yielded the best prediction of the subsequent development of schizophrenia spectrum disorders. Escalating transitions within the spectrum (i.e., from schizotypal disorder to schizophrenia) were not associated to any candidate psychopathological predictor.

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JO - World Psychiatry

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ER -

Self-experience in the early phases of schizophrenia: 5-year follow-up of the Copenhagen Prodromal Study

Abstract

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