SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

A. Andersen; Claus Cornett; A. Lauridsen; C. E. Olsen; S. B. Christensen

SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

A. Andersen, Claus Cornett, A. Lauridsen, C. E. Olsen, S. B. Christensen

Abstract

The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.

Original language	Undefined/Unknown
Journal	Acta Chemica Scandinavica. Supplementum
Volume	48
Issue number	4
Pages (from-to)	340-346
Number of pages	7
ISSN	0065-1133
Publication status	Published - 1994

Cite this

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title = "SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN",

abstract = "The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.",

keywords = "ca2+ transport atpases reticulum ca-2+-atpase thapsia-garganica tumor promoter high-affinity",

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year = "1994",

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pages = "340--346",

journal = "Acta Chemica Scandinavica. Supplementum",

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TY - JOUR

T1 - SELECTIVE TRANSFORMATIONS OF THE CA-2+ PUMP INHIBITOR THAPSIGARGIN

AU - Andersen, A.

AU - Cornett, Claus

AU - Lauridsen, A.

AU - Olsen, C. E.

AU - Christensen, S. B.

PY - 1994

Y1 - 1994

N2 - The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.

AB - The importance of the sesquiterpene lactone thapsigargin as a tool for studying Ca2+ homeostasis has created a need for structure-activity relationship studies and consequently for procedures for selective transformations of the functional groups in the molecule. Methods for the selective inversion of configuration at C-3 and C-8, selective acetylation, and selective cleavage of the ester groups at 0-3, 0-8 and 0-10 are presented.

KW - ca2+ transport atpases reticulum ca-2+-atpase thapsia-garganica tumor promoter high-affinity

M3 - Tidsskriftartikel

SN - 0065-1133

VL - 48

SP - 340

EP - 346

JO - Acta Chemica Scandinavica. Supplementum

JF - Acta Chemica Scandinavica. Supplementum

IS - 4

ER -