Seeding after ultrasound-guided percutaneous biopsy of liver metastases in patients with colorectal or breast cancer

TY - JOUR

T1 - Seeding after ultrasound-guided percutaneous biopsy of liver metastases in patients with colorectal or breast cancer

AU - Chen, Inna

AU - Lorentzen, Torben

AU - Linnemann, Dorte

AU - Nolsøe, Christian Pállson

AU - Skjoldbye, Bjørn

AU - Jensen, Benny V

AU - Nielsen, Dorte

PY - 2016/5/3

Y1 - 2016/5/3

N2 - Abstract: Background: Neoplasm seeding is a serious complication after liver metastases biopsy. Reported incidences vary between 10% and 19% for colorectal cancer (CRC) and are unknown for breast cancer (BC). The aim of this retrospective study was to determine the frequency of tumor seeding after ultrasound-guided percutaneous biopsy of CRC and BC liver metastases. Material and methods: Unselected liver biopsies performed in the period of 2005–2012 at our institution were extracted from the National Pathology Registry. Medical records including imaging from patients with biopsy-verified BC and CRC liver metastases were retrospectively reviewed. The endpoint was the development of abdominal wall recurrence following liver biopsy. Results: Of total 2981 biopsies we identified 278 patients with CRC and 155 patients with BC biopsy-verified liver metastases. During the median follow-up of 25 months after biopsy (range 3–253 months), no seeding was recorded in patients with BC. Within the median follow-up of 34 months (3–111 months), seeding was registered in 17/278 (6%) of patients with CRC; three patients of 278 (1%) had undoubtedly biopsy-related seeding, which became apparent six, nine, and 26 months after biopsy, respectively; and in nine patients (3%) seeding occurred due to either biopsy or other interventions; and five patients had seeding, which were assessed as a consequence of other invasive procedures than biopsies. The median overall survival of the 17 patients with seeding was 70 months compared to 39 months of patients without seeding. Conclusions: The results showed no seeding in BC patients. Seeding rate after biopsy in CRC patients is not negligible, however, without affecting outcome.

AB - Abstract: Background: Neoplasm seeding is a serious complication after liver metastases biopsy. Reported incidences vary between 10% and 19% for colorectal cancer (CRC) and are unknown for breast cancer (BC). The aim of this retrospective study was to determine the frequency of tumor seeding after ultrasound-guided percutaneous biopsy of CRC and BC liver metastases. Material and methods: Unselected liver biopsies performed in the period of 2005–2012 at our institution were extracted from the National Pathology Registry. Medical records including imaging from patients with biopsy-verified BC and CRC liver metastases were retrospectively reviewed. The endpoint was the development of abdominal wall recurrence following liver biopsy. Results: Of total 2981 biopsies we identified 278 patients with CRC and 155 patients with BC biopsy-verified liver metastases. During the median follow-up of 25 months after biopsy (range 3–253 months), no seeding was recorded in patients with BC. Within the median follow-up of 34 months (3–111 months), seeding was registered in 17/278 (6%) of patients with CRC; three patients of 278 (1%) had undoubtedly biopsy-related seeding, which became apparent six, nine, and 26 months after biopsy, respectively; and in nine patients (3%) seeding occurred due to either biopsy or other interventions; and five patients had seeding, which were assessed as a consequence of other invasive procedures than biopsies. The median overall survival of the 17 patients with seeding was 70 months compared to 39 months of patients without seeding. Conclusions: The results showed no seeding in BC patients. Seeding rate after biopsy in CRC patients is not negligible, however, without affecting outcome.

KW - Abdominal Wall

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Breast Neoplasms

KW - Colorectal Neoplasms

KW - Endoscopic Ultrasound-Guided Fine Needle Aspiration

KW - Female

KW - Humans

KW - Incidence

KW - Liver Neoplasms

KW - Male

KW - Middle Aged

KW - Neoplasm Seeding

KW - Retrospective Studies

KW - Tomography, X-Ray Computed

KW - Ultrasonography

KW - Journal Article

U2 - 10.3109/0284186x.2015.1093657

DO - 10.3109/0284186x.2015.1093657

M3 - Journal article

C2 - 26457338

SN - 0284-186X

VL - 55

SP - 638

EP - 643

JO - Acta Oncologica

JF - Acta Oncologica

IS - 5

ER -