SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents

André Scherag; Michaela Kleber; Tanja Boes; Andreea-Liliana Kolbe; Anne Ruth; Harald Grallert; Thomas Illig; Iris M Heid; André M Toschke; Katrine Grau; Thorkild I A Sørensen; Johannes Hebebrand; Anke Hinney; Thomas Reinehr; NUGENOB Consortium

doi:10.1038/oby.2011.339

SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents

André Scherag, Michaela Kleber, Tanja Boes, Andreea-Liliana Kolbe, Anne Ruth, Harald Grallert, Thomas Illig, Iris M Heid, André M Toschke, Katrine Grau, Thorkild I A Sørensen, Johannes Hebebrand, Anke Hinney, Thomas Reinehr, NUGENOB Consortium

18 Citations (Scopus)

Abstract

Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.

Original language	English
Journal	Obesity
Volume	20
Issue number	2
Pages (from-to)	466-70
Number of pages	5
ISSN	1930-7381
DOIs	https://doi.org/10.1038/oby.2011.339
Publication status	Published - Feb 2012

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10.1038/oby.2011.339

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Scherag, A., Kleber, M., Boes, T., Kolbe, A-L., Ruth, A., Grallert, H., Illig, T., Heid, I. M., Toschke, A. M., Grau, K., Sørensen, T. I. A., Hebebrand, J., Hinney, A., Reinehr, T., & NUGENOB Consortium (2012). SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. Obesity, 20(2), 466-70. https://doi.org/10.1038/oby.2011.339

Scherag, A, Kleber, M, Boes, T, Kolbe, A-L, Ruth, A, Grallert, H, Illig, T, Heid, IM, Toschke, AM, Grau, K, Sørensen, TIA, Hebebrand, J, Hinney, A, Reinehr, T & NUGENOB Consortium 2012, 'SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents', Obesity, vol. 20, no. 2, pp. 466-70. https://doi.org/10.1038/oby.2011.339

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title = "SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents",

abstract = "Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.",

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AU - Scherag, André

AU - Kleber, Michaela

AU - Boes, Tanja

AU - Kolbe, Andreea-Liliana

AU - Ruth, Anne

AU - Grallert, Harald

AU - Illig, Thomas

AU - Heid, Iris M

AU - Toschke, André M

AU - Grau, Katrine

AU - Sørensen, Thorkild I A

AU - Hebebrand, Johannes

AU - Hinney, Anke

AU - Reinehr, Thomas

AU - NUGENOB Consortium

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N2 - Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.

AB - Genome-wide association analyses (GWAS) contributed to the detection of a number of single-nucleotide polymorphisms (SNPs) associated with obesity. However, little is known about the impact of the obesity-risk alleles on weight loss-related phenotypes after lifestyle interventions. A recent meta-analysis of GWAS reported five genomic loci near or in the genes FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA that were associated with obesity in children and adolescents. Here, we analyzed the effect of the 10 SNPs representative of the five loci on measures of weight loss and cardiometabolic risk after a 1-year lifestyle intervention in 401 children and adolescents (mean age 10.74 years; 55.4% female; mean BMI 27.42 kg/m(2), mean BMI-standard deviation score (SDS) 2.37). For confirmation of one locus genotyping of three intronic SNPs in SDCCAG8 was performed in 626 obese adults who completed the 10-week hypoenergetic diet program. Intronic variants of SDCCAG8, which are associated with early onset obesity, are associated with reduced weight loss after a 1-year lifestyle intervention in overweight children and adolescents even after adjusting for age, sex, baseline measurement, or multiple testing (all P <10(-6)). However, our results could not be confirmed in 626 obese adults undertaking a hypoenergetic diet intervention.

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SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents

Abstract

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