Screening of the Ito regulatory subunit Klf15 in patients with early-onset lone atrial fibrillation

TY - JOUR

T1 - Screening of the Ito regulatory subunit Klf15 in patients with early-onset lone atrial fibrillation

AU - Nielsen, Morten Wagner

AU - Olesen, Morten Salling

AU - Refsgaard, Lena

AU - Haunsø, Stig

AU - Svendsen, Jesper Hastrup

PY - 2013

Y1 - 2013

N2 - Several studies have associated mutations in genes encoding potassium channels and accessory subunits involved in cardiac repolarization with increased susceptibility of atrial fibrillation (AF). Recently, the Krüppel-like factor 15 (Klf15) was found to transcriptionally control rhythmic expression of KChIP2, a critical subunit required for generating the transient outward potassium current (Ito), and that deficiency or excess of Klf15 increased the susceptibility of arrhythmias. On this basis we hypothesized that mutations in Klf15 could be associated with AF. A total of 209 unrelated Caucasian lone AF patients were screened for mutations in Klf15 by direct sequencing. No mutations in the lone AF cohort were found. In one patient we found a synonymous variant (c.36C > T). In NHLBI GO Exome Sequencing Project (ESP) the variant was present in 31 of 4269 Caucasian individuals and in 3 of 2200 African Americans. In our cohort Klf15 was not associated with lone AF.

AB - Several studies have associated mutations in genes encoding potassium channels and accessory subunits involved in cardiac repolarization with increased susceptibility of atrial fibrillation (AF). Recently, the Krüppel-like factor 15 (Klf15) was found to transcriptionally control rhythmic expression of KChIP2, a critical subunit required for generating the transient outward potassium current (Ito), and that deficiency or excess of Klf15 increased the susceptibility of arrhythmias. On this basis we hypothesized that mutations in Klf15 could be associated with AF. A total of 209 unrelated Caucasian lone AF patients were screened for mutations in Klf15 by direct sequencing. No mutations in the lone AF cohort were found. In one patient we found a synonymous variant (c.36C > T). In NHLBI GO Exome Sequencing Project (ESP) the variant was present in 31 of 4269 Caucasian individuals and in 3 of 2200 African Americans. In our cohort Klf15 was not associated with lone AF.

U2 - 10.3389/fgene.2013.00088

DO - 10.3389/fgene.2013.00088

M3 - Journal article

C2 - 23730307

SN - 1664-8021

VL - 4

SP - 1

EP - 2

JO - Frontiers in Genetics

JF - Frontiers in Genetics

M1 - 88

ER -