TY - JOUR
T1 - Screening for Y microdeletions in men with testicular cancer and undescended testis
AU - Bor, Pinar
AU - Hindkjaer, Johnny
AU - Kølvraa, Steen
AU - Rossen, Philip
AU - von der Maase, Hans
AU - Jørgensen, Troels Munch
AU - Sørensen, Viggo Tønning
AU - Eiberg, Hans
AU - Ingerslev, Hans Jakob
N1 - Keywords: Adult; Chromosome Deletion; Chromosomes, Human, Y; Cryptorchidism; Genetic Testing; Humans; Male; Middle Aged; Testicular Neoplasms
PY - 2006
Y1 - 2006
N2 - PURPOSE: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. METHODS: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions. RESULTS: A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. CONCLUSIONS: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.
AB - PURPOSE: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. METHODS: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions. RESULTS: A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. CONCLUSIONS: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.
U2 - 10.1007/s10815-005-9001-5
DO - 10.1007/s10815-005-9001-5
M3 - Journal article
C2 - 16550456
SN - 1058-0468
VL - 23
SP - 41
EP - 45
JO - Journal of Assisted Reproduction and Genetics
JF - Journal of Assisted Reproduction and Genetics
IS - 1
ER -
