Screening for allergic respiratory disease in the general population with the ADVIA Centaur Allergy Screen Assay

A Linneberg; L L N Husemoen; N H Nielsen; F Madsen; L Frølund

doi:10.1111/j.1398-9995.2006.00968.x

Screening for allergic respiratory disease in the general population with the ADVIA Centaur Allergy Screen Assay

A Linneberg, L L N Husemoen, N H Nielsen, F Madsen, L Frølund

22 Citations (Scopus)

Abstract

BACKGROUND: In patients in whom the clinical indication for immunoglobulin E (IgE)-mediated allergic respiratory disease is weak, a single qualitative multiallergen-screening assay for IgE antibody to multiple allergen specificities may support the absence of IgE-mediated allergic respiratory disease. The aim was to investigate the diagnostic efficacy of a new multiallergen-screening assay in relation to skin prick test (SPT) reactivity and objective diagnoses of allergic respiratory disease in a general population setting.

METHODS: A total of 709 participants in a population-based study were examined by questionnaire and SPT. Serum was analysed by using a multiallergen-screening assay: the ADVIA Centaur Allergy Screen (AS) assay. The dichotomized result of the AS assay was compared with SPT reactivity, specific IgE positivity, and a clinical diagnosis of allergic rhinitis or allergic asthma defined by the presence of relevant symptoms and positive SPTs.

RESULTS: Sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of the AS against SPT reactivity were 86%, 96%, 94%, and 89%, respectively. A negative AS assay test was able to exclude allergic rhinitis and allergic asthma with a probability of more than 96% and 98% (NPV), respectively. The AS assay was able to identify more than 92% and 92% (sensitivity) of cases of allergic rhinitis and allergic asthma, respectively.

CONCLUSIONS: The AS assay proved to be a valid measure of allergic respiratory disease and may be used as a screening tool to rule out allergic respiratory disease, and as an objective measure of allergic respiratory disease in epidemiological studies.

Original language	English
Journal	Allergy
Volume	61
Issue number	3
Pages (from-to)	344-8
Number of pages	5
ISSN	0105-4538
DOIs	https://doi.org/10.1111/j.1398-9995.2006.00968.x
Publication status	Published - Mar 2006
Externally published	Yes

Keywords

Antibodies, Anti-Idiotypic
Asthma
Cohort Studies
Confidence Intervals
Desensitization, Immunologic
Female
Humans
Hypersensitivity, Immediate
Immunoglobulin E
Immunologic Tests
Male
Mass Screening
Prevalence
Probability
Prospective Studies
Respiratory Hypersensitivity
Rhinitis, Allergic, Seasonal
Risk Assessment
Sensitivity and Specificity
Severity of Illness Index
Skin Tests
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

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10.1111/j.1398-9995.2006.00968.x

Cite this

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title = "Screening for allergic respiratory disease in the general population with the ADVIA Centaur Allergy Screen Assay",

abstract = "BACKGROUND: In patients in whom the clinical indication for immunoglobulin E (IgE)-mediated allergic respiratory disease is weak, a single qualitative multiallergen-screening assay for IgE antibody to multiple allergen specificities may support the absence of IgE-mediated allergic respiratory disease. The aim was to investigate the diagnostic efficacy of a new multiallergen-screening assay in relation to skin prick test (SPT) reactivity and objective diagnoses of allergic respiratory disease in a general population setting.METHODS: A total of 709 participants in a population-based study were examined by questionnaire and SPT. Serum was analysed by using a multiallergen-screening assay: the ADVIA Centaur Allergy Screen (AS) assay. The dichotomized result of the AS assay was compared with SPT reactivity, specific IgE positivity, and a clinical diagnosis of allergic rhinitis or allergic asthma defined by the presence of relevant symptoms and positive SPTs.RESULTS: Sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of the AS against SPT reactivity were 86%, 96%, 94%, and 89%, respectively. A negative AS assay test was able to exclude allergic rhinitis and allergic asthma with a probability of more than 96% and 98% (NPV), respectively. The AS assay was able to identify more than 92% and 92% (sensitivity) of cases of allergic rhinitis and allergic asthma, respectively.CONCLUSIONS: The AS assay proved to be a valid measure of allergic respiratory disease and may be used as a screening tool to rule out allergic respiratory disease, and as an objective measure of allergic respiratory disease in epidemiological studies.",

keywords = "Antibodies, Anti-Idiotypic, Asthma, Cohort Studies, Confidence Intervals, Desensitization, Immunologic, Female, Humans, Hypersensitivity, Immediate, Immunoglobulin E, Immunologic Tests, Male, Mass Screening, Prevalence, Probability, Prospective Studies, Respiratory Hypersensitivity, Rhinitis, Allergic, Seasonal, Risk Assessment, Sensitivity and Specificity, Severity of Illness Index, Skin Tests, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",

author = "A Linneberg and Husemoen, {L L N} and Nielsen, {N H} and F Madsen and L Fr{\o}lund",

year = "2006",

month = mar,

doi = "10.1111/j.1398-9995.2006.00968.x",

language = "English",

volume = "61",

pages = "344--8",

journal = "Allergy: European Journal of Allergy and Clinical Immunology",

issn = "0105-4538",

publisher = "Wiley Online",

number = "3",

}

TY - JOUR

T1 - Screening for allergic respiratory disease in the general population with the ADVIA Centaur Allergy Screen Assay

AU - Linneberg, A

AU - Husemoen, L L N

AU - Nielsen, N H

AU - Madsen, F

AU - Frølund, L

PY - 2006/3

Y1 - 2006/3

N2 - BACKGROUND: In patients in whom the clinical indication for immunoglobulin E (IgE)-mediated allergic respiratory disease is weak, a single qualitative multiallergen-screening assay for IgE antibody to multiple allergen specificities may support the absence of IgE-mediated allergic respiratory disease. The aim was to investigate the diagnostic efficacy of a new multiallergen-screening assay in relation to skin prick test (SPT) reactivity and objective diagnoses of allergic respiratory disease in a general population setting.METHODS: A total of 709 participants in a population-based study were examined by questionnaire and SPT. Serum was analysed by using a multiallergen-screening assay: the ADVIA Centaur Allergy Screen (AS) assay. The dichotomized result of the AS assay was compared with SPT reactivity, specific IgE positivity, and a clinical diagnosis of allergic rhinitis or allergic asthma defined by the presence of relevant symptoms and positive SPTs.RESULTS: Sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of the AS against SPT reactivity were 86%, 96%, 94%, and 89%, respectively. A negative AS assay test was able to exclude allergic rhinitis and allergic asthma with a probability of more than 96% and 98% (NPV), respectively. The AS assay was able to identify more than 92% and 92% (sensitivity) of cases of allergic rhinitis and allergic asthma, respectively.CONCLUSIONS: The AS assay proved to be a valid measure of allergic respiratory disease and may be used as a screening tool to rule out allergic respiratory disease, and as an objective measure of allergic respiratory disease in epidemiological studies.

AB - BACKGROUND: In patients in whom the clinical indication for immunoglobulin E (IgE)-mediated allergic respiratory disease is weak, a single qualitative multiallergen-screening assay for IgE antibody to multiple allergen specificities may support the absence of IgE-mediated allergic respiratory disease. The aim was to investigate the diagnostic efficacy of a new multiallergen-screening assay in relation to skin prick test (SPT) reactivity and objective diagnoses of allergic respiratory disease in a general population setting.METHODS: A total of 709 participants in a population-based study were examined by questionnaire and SPT. Serum was analysed by using a multiallergen-screening assay: the ADVIA Centaur Allergy Screen (AS) assay. The dichotomized result of the AS assay was compared with SPT reactivity, specific IgE positivity, and a clinical diagnosis of allergic rhinitis or allergic asthma defined by the presence of relevant symptoms and positive SPTs.RESULTS: Sensitivity, specificity, and positive (PPV) and negative predictive values (NPV) of the AS against SPT reactivity were 86%, 96%, 94%, and 89%, respectively. A negative AS assay test was able to exclude allergic rhinitis and allergic asthma with a probability of more than 96% and 98% (NPV), respectively. The AS assay was able to identify more than 92% and 92% (sensitivity) of cases of allergic rhinitis and allergic asthma, respectively.CONCLUSIONS: The AS assay proved to be a valid measure of allergic respiratory disease and may be used as a screening tool to rule out allergic respiratory disease, and as an objective measure of allergic respiratory disease in epidemiological studies.

KW - Antibodies, Anti-Idiotypic

KW - Asthma

KW - Cohort Studies

KW - Confidence Intervals

KW - Desensitization, Immunologic

KW - Female

KW - Humans

KW - Hypersensitivity, Immediate

KW - Immunoglobulin E

KW - Immunologic Tests

KW - Male

KW - Mass Screening

KW - Prevalence

KW - Probability

KW - Prospective Studies

KW - Respiratory Hypersensitivity

KW - Rhinitis, Allergic, Seasonal

KW - Risk Assessment

KW - Sensitivity and Specificity

KW - Severity of Illness Index

KW - Skin Tests

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1111/j.1398-9995.2006.00968.x

DO - 10.1111/j.1398-9995.2006.00968.x

M3 - Journal article

C2 - 16436144

SN - 0105-4538

VL - 61

SP - 344

EP - 348

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 3

ER -

Screening for allergic respiratory disease in the general population with the ADVIA Centaur Allergy Screen Assay

Abstract

Keywords

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