Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

Gerald Stober; Dorit Ben-Shachar; M Cardon; Peter Falkai; Alfred N Fonteh; Micha Gawlik; Birte Yding Glenthøj; Edna Grunblatt; Assen Jablensky; Yong-Ku Kim; Johannes Kornhuber; Thomas F McNeil; Norbert Muller; Bob Oranje; Toshikazu Saito; Mohamed Saoud; Andrea Schmitt; Michal Schwartz; Johannes Thome; Marat Uzbekov; Nuria Durany; Peter Riederer; Gerald Stober; Dorit Ben-Shachar; M Cardon; Peter Falkai; Alfred N Fonteh; Micha Gawlik; Birte Yding Glenthøj; Edna Grunblatt; Assen Jablensky; Yong-Ku Kim; Johannes Kornhuber; Thomas F McNeil; Norbert Muller; Bob Oranje; Toshikazu Saito; Mohamed Saoud; Andrea Schmitt; Michal Schwartz; Johannes Thome; Marat Uzbekov; Nuria Durany; Peter Riederer

doi:10.1080/15622970902898980

Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

Gerald Stober, Dorit Ben-Shachar, M Cardon, Peter Falkai, Alfred N Fonteh, Micha Gawlik, Birte Yding Glenthøj, Edna Grunblatt, Assen Jablensky, Yong-Ku Kim, Johannes Kornhuber, Thomas F McNeil, Norbert Muller, Bob Oranje, Toshikazu Saito, Mohamed Saoud, Andrea Schmitt, Michal Schwartz, Johannes Thome, Marat UzbekovNuria Durany, Peter Riederer, Gerald Stober, Dorit Ben-Shachar, M Cardon, Peter Falkai, Alfred N Fonteh, Micha Gawlik, Birte Yding Glenthøj, Edna Grunblatt, Assen Jablensky, Yong-Ku Kim, Johannes Kornhuber, Thomas F McNeil, Norbert Muller, Bob Oranje, Toshikazu Saito, Mohamed Saoud, Andrea Schmitt, Michal Schwartz, Johannes Thome, Marat Uzbekov, Nuria Durany, Peter Riederer

67 Citations (Scopus)

Abstract

Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.

Original language	English
Journal	World Journal of Biological Psychiatry
Volume	10
Issue number	2
Pages (from-to)	127-55
Number of pages	28
ISSN	1562-2975
DOIs	https://doi.org/10.1080/15622970902898980 https://doi.org/10.1080/15622970902898980
Publication status	Published - 2009

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Stober, G., Ben-Shachar, D., Cardon, M., Falkai, P., Fonteh, A. N., Gawlik, M., Glenthøj, B. Y., Grunblatt, E., Jablensky, A., Kim, Y.-K., Kornhuber, J., McNeil, T. F., Muller, N., Oranje, B., Saito, T., Saoud, M., Schmitt, A., Schwartz, M., Thome, J., ... Riederer, P. (2009). Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers. World Journal of Biological Psychiatry, 10(2), 127-55. https://doi.org/10.1080/15622970902898980, https://doi.org/10.1080/15622970902898980

Stober, G, Ben-Shachar, D, Cardon, M, Falkai, P, Fonteh, AN, Gawlik, M, Glenthøj, BY, Grunblatt, E, Jablensky, A, Kim, Y-K, Kornhuber, J, McNeil, TF, Muller, N, Oranje, B, Saito, T, Saoud, M, Schmitt, A, Schwartz, M, Thome, J, Uzbekov, M, Durany, N, Riederer, P, Stober, G, Ben-Shachar, D, Cardon, M, Falkai, P, Fonteh, AN, Gawlik, M, Glenthøj, BY, Grunblatt, E, Jablensky, A, Kim, Y-K, Kornhuber, J, McNeil, TF, Muller, N, Oranje, B, Saito, T, Saoud, M, Schmitt, A, Schwartz, M, Thome, J, Uzbekov, M, Durany, N & Riederer, P 2009, 'Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers', World Journal of Biological Psychiatry, vol. 10, no. 2, pp. 127-55. https://doi.org/10.1080/15622970902898980, https://doi.org/10.1080/15622970902898980

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title = "Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers",

abstract = "Objective. The phenotypic complexity, together with the multifarious nature of the so-called {"}schizophrenic psychoses{"}, limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.",

author = "Gerald Stober and Dorit Ben-Shachar and M Cardon and Peter Falkai and Fonteh, {Alfred N} and Micha Gawlik and Glenth{\o}j, {Birte Yding} and Edna Grunblatt and Assen Jablensky and Yong-Ku Kim and Johannes Kornhuber and McNeil, {Thomas F} and Norbert Muller and Bob Oranje and Toshikazu Saito and Mohamed Saoud and Andrea Schmitt and Michal Schwartz and Johannes Thome and Marat Uzbekov and Nuria Durany and Peter Riederer and Gerald Stober and Dorit Ben-Shachar and M Cardon and Peter Falkai and Fonteh, {Alfred N} and Micha Gawlik and Glenth{\o}j, {Birte Yding} and Edna Grunblatt and Assen Jablensky and Yong-Ku Kim and Johannes Kornhuber and McNeil, {Thomas F} and Norbert Muller and Bob Oranje and Toshikazu Saito and Mohamed Saoud and Andrea Schmitt and Michal Schwartz and Johannes Thome and Marat Uzbekov and Nuria Durany and Peter Riederer",

note = "Keywords: Biological Markers; Brain; Chromosome Mapping; Genetic Markers; Genetic Predisposition to Disease; Humans; Phenotype; Schizophrenia; Schizophrenic Psychology",

year = "2009",

doi = "10.1080/15622970902898980",

language = "English",

volume = "10",

pages = "127--55",

journal = "World Journal of Biological Psychiatry",

issn = "1562-2975",

publisher = "Taylor & Francis",

number = "2",

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TY - JOUR

T1 - Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

AU - Stober, Gerald

AU - Ben-Shachar, Dorit

AU - Cardon, M

AU - Falkai, Peter

AU - Fonteh, Alfred N

AU - Gawlik, Micha

AU - Glenthøj, Birte Yding

AU - Grunblatt, Edna

AU - Jablensky, Assen

AU - Kim, Yong-Ku

AU - Kornhuber, Johannes

AU - McNeil, Thomas F

AU - Muller, Norbert

AU - Oranje, Bob

AU - Saito, Toshikazu

AU - Saoud, Mohamed

AU - Schmitt, Andrea

AU - Schwartz, Michal

AU - Thome, Johannes

AU - Uzbekov, Marat

AU - Durany, Nuria

AU - Riederer, Peter

AU - Stober, Gerald

AU - Ben-Shachar, Dorit

AU - Cardon, M

AU - Falkai, Peter

AU - Fonteh, Alfred N

AU - Gawlik, Micha

AU - Glenthøj, Birte Yding

AU - Grunblatt, Edna

AU - Jablensky, Assen

AU - Kim, Yong-Ku

AU - Kornhuber, Johannes

AU - McNeil, Thomas F

AU - Muller, Norbert

AU - Oranje, Bob

AU - Saito, Toshikazu

AU - Saoud, Mohamed

AU - Schmitt, Andrea

AU - Schwartz, Michal

AU - Thome, Johannes

AU - Uzbekov, Marat

AU - Durany, Nuria

AU - Riederer, Peter

N1 - Keywords: Biological Markers; Brain; Chromosome Mapping; Genetic Markers; Genetic Predisposition to Disease; Humans; Phenotype; Schizophrenia; Schizophrenic Psychology

PY - 2009

Y1 - 2009

N2 - Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.

AB - Objective. The phenotypic complexity, together with the multifarious nature of the so-called "schizophrenic psychoses", limits our ability to form a simple and logical biologically based hypothesis for the disease group. Biological markers are defined as biochemical, physiological or anatomical traits that are specific to particular conditions. An important aim of biomarker discovery is the detection of disease correlates that can be used as diagnostic tools. Method. A selective review of the WFSBP Task Force on Biological Markers in schizophrenia is provided from the central nervous system to phenotypes, functional brain systems, chromosomal loci with potential genetic markers to the peripheral systems. Results. A number of biological measures have been proposed to be correlated with schizophrenia. At present, not a single biological trait in schizophrenia is available which achieves sufficient specificity, selectivity and is based on causal pathology and predictive validity to be recommended as diagnostic marker. Conclusions. With the emergence of new technologies and rigorous phenotypic subclassification the identification of genetic bases and assessment of dynamic disease related alterations will hopefully come to a new stage in the complex field of psychiatric research.

U2 - 10.1080/15622970902898980

DO - 10.1080/15622970902898980

M3 - Journal article

C2 - 19396704

SN - 1562-2975

VL - 10

SP - 127

EP - 155

JO - World Journal of Biological Psychiatry

JF - World Journal of Biological Psychiatry

IS - 2

ER -

Schizophrenia: from the brain to peripheral markers. A consensus paper of the WFSBP task force on biological markers

Abstract

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