Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

Mirjana Tosic; Jurg Ott; Sandra Barral; Pierre Bovet; Patricia Deppen; Fulvia Gheorghita; Marie-Louise Matthey; Josef Parnas; Martin Preisig; Michael Saraga; Alessandra Solida; Sally Timm; August G Wang; Thomas Werge; Michel Cuénod; Kim Quang Do

doi:http://dx.doi.org/10.1086/507566

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

Mirjana Tosic, Jurg Ott, Sandra Barral, Pierre Bovet, Patricia Deppen, Fulvia Gheorghita, Marie-Louise Matthey, Josef Parnas, Martin Preisig, Michael Saraga, Alessandra Solida, Sally Timm, August G Wang, Thomas Werge, Michel Cuénod, Kim Quang Do

182 Citations (Scopus)

Abstract

Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

Original language	English
Journal	American Journal of Human Genetics
Volume	79
Issue number	3
Pages (from-to)	586-592
Number of pages	7
ISSN	0002-9297
DOIs	https://doi.org/10.1086/507566
Publication status	Published - 2006

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Tosic, M., Ott, J., Barral, S., Bovet, P., Deppen, P., Gheorghita, F., Matthey, M-L., Parnas, J., Preisig, M., Saraga, M., Solida, A., Timm, S., Wang, A. G., Werge, T., Cuénod, M., & Do, K. Q. (2006). Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene. American Journal of Human Genetics, 79(3), 586-592. https://doi.org/10.1086/507566

Tosic, M, Ott, J, Barral, S, Bovet, P, Deppen, P, Gheorghita, F, Matthey, M-L, Parnas, J, Preisig, M, Saraga, M, Solida, A, Timm, S, Wang, AG, Werge, T, Cuénod, M & Do, KQ 2006, 'Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene', American Journal of Human Genetics, vol. 79, no. 3, pp. 586-592. https://doi.org/10.1086/507566

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title = "Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene",

abstract = "Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.",

author = "Mirjana Tosic and Jurg Ott and Sandra Barral and Pierre Bovet and Patricia Deppen and Fulvia Gheorghita and Marie-Louise Matthey and Josef Parnas and Martin Preisig and Michael Saraga and Alessandra Solida and Sally Timm and Wang, {August G} and Thomas Werge and Michel Cu{\'e}nod and Do, {Kim Quang}",

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pages = "586--592",

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T1 - Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

AU - Tosic, Mirjana

AU - Ott, Jurg

AU - Barral, Sandra

AU - Bovet, Pierre

AU - Deppen, Patricia

AU - Gheorghita, Fulvia

AU - Matthey, Marie-Louise

AU - Parnas, Josef

AU - Preisig, Martin

AU - Saraga, Michael

AU - Solida, Alessandra

AU - Timm, Sally

AU - Wang, August G

AU - Werge, Thomas

AU - Cuénod, Michel

AU - Do, Kim Quang

PY - 2006

Y1 - 2006

N2 - Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

AB - Oxidative stress could be involved in the pathophysiology of schizophrenia, a major psychiatric disorder. Glutathione (GSH), a redox regulator, is decreased in patients' cerebrospinal fluid and prefrontal cortex. The gene of the key GSH-synthesizing enzyme, glutamate cysteine ligase modifier (GCLM) subunit, is strongly associated with schizophrenia in two case-control studies and in one family study. GCLM gene expression is decreased in patients' fibroblasts. Thus, GSH metabolism dysfunction is proposed as one of the vulnerability factors for schizophrenia.

U2 - http://dx.doi.org/10.1086/507566

DO - http://dx.doi.org/10.1086/507566

M3 - Journal article

SN - 0002-9297

VL - 79

SP - 586

EP - 592

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

IS - 3

ER -

Schizophrenia and oxidative stress: glutamate cysteine ligase modifier as a susceptibility gene

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