Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis

Christian Erikstrup; Per Kallestrup; Rutendo B L Zinyama-Gutsire; Exnevia Gomo; Govert J van Dam; André M. Deelder; Anthony E Butterworth; Bente Klarlund Pedersen; Sisse R Ostrowski; Jan Gerstoft; Henrik Ullum

Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis

Christian Erikstrup, Per Kallestrup, Rutendo B L Zinyama-Gutsire, Exnevia Gomo, Govert J van Dam, André M. Deelder, Anthony E Butterworth, Bente Klarlund Pedersen, Sisse R Ostrowski, Jan Gerstoft, Henrik Ullum

Department of Clinical Medicine

Abstract

We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.

Original language	English
Journal	American Journal of Tropical Medicine and Hygiene
Volume	79
Issue number	3
Pages (from-to)	331-7
Number of pages	7
ISSN	0002-9637
Publication status	Published - Sept 2008

Keywords

Adolescent
Adult
Cohort Studies
Cross-Sectional Studies
Cytokines
Female
HIV Infections
HIV-1
Humans
Inflammation
Interleukin-10
Interleukin-8
Male
Middle Aged
Praziquantel
Receptors, Tumor Necrosis Factor, Type II
Schistosomiasis
Schistosomicides
Zimbabwe
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Erikstrup, C., Kallestrup, P., Zinyama-Gutsire, R. B. L., Gomo, E., van Dam, G. J., Deelder, A. M., Butterworth, A. E., Pedersen, B. K., Ostrowski, S. R., Gerstoft, J., & Ullum, H. (2008). Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis. American Journal of Tropical Medicine and Hygiene, 79(3), 331-7.

Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe : systemic inflammation during co-infection and after treatment for schistosomiasis. / Erikstrup, Christian; Kallestrup, Per; Zinyama-Gutsire, Rutendo B L et al.

In: American Journal of Tropical Medicine and Hygiene, Vol. 79, No. 3, 09.2008, p. 331-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Erikstrup, C, Kallestrup, P, Zinyama-Gutsire, RBL, Gomo, E, van Dam, GJ, Deelder, AM, Butterworth, AE, Pedersen, BK , Ostrowski, SR , Gerstoft, J & Ullum, H 2008, 'Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis', American Journal of Tropical Medicine and Hygiene, vol. 79, no. 3, pp. 331-7.

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abstract = "We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.",

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AU - Erikstrup, Christian

AU - Kallestrup, Per

AU - Zinyama-Gutsire, Rutendo B L

AU - Gomo, Exnevia

AU - van Dam, Govert J

AU - Deelder, André M.

AU - Butterworth, Anthony E

AU - Pedersen, Bente Klarlund

AU - Ostrowski, Sisse R

AU - Gerstoft, Jan

AU - Ullum, Henrik

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N2 - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.

AB - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation.

KW - Adolescent

KW - Adult

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - Cytokines

KW - Female

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Inflammation

KW - Interleukin-10

KW - Interleukin-8

KW - Male

KW - Middle Aged

KW - Praziquantel

KW - Receptors, Tumor Necrosis Factor, Type II

KW - Schistosomiasis

KW - Schistosomicides

KW - Zimbabwe

KW - Journal Article

KW - Randomized Controlled Trial

KW - Research Support, Non-U.S. Gov't

KW - Research Support, U.S. Gov't, P.H.S.

M3 - Journal article

C2 - 18784223

SN - 0002-9637

VL - 79

SP - 331

EP - 337

JO - Journal. National Malaria Society

JF - Journal. National Malaria Society

IS - 3

ER -

Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis

Abstract

Keywords

UN SDGs

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