Erikstrup, C., Kallestrup, P., Zinyama-Gutsire, R. B., Gomo, E., Dam, G. J. V., Deelder, A. M., Butterworth, A. E., Pedersen, B. K., Ostrowski, S. R., Gerstoft, J., & Ullum, H. (2008). Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis. American Journal of Tropical Medicine and Hygiene, 79(3), 331-337.
Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis. / Erikstrup, C.; Kallestrup, P.; Zinyama-Gutsire, R.B. et al.
In:
American Journal of Tropical Medicine and Hygiene, Vol. 79, No. 3, 2008, p. 331-337.
Research output: Contribution to journal › Journal article › Research › peer-review
Erikstrup, C, Kallestrup, P, Zinyama-Gutsire, RB, Gomo, E, Dam, GJV, Deelder, AM, Butterworth, AE, Pedersen, BK, Ostrowski, SR, Gerstoft, J & Ullum, H 2008, 'Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis', American Journal of Tropical Medicine and Hygiene, vol. 79, no. 3, pp. 331-337.
Erikstrup C, Kallestrup P, Zinyama-Gutsire RB, Gomo E, Dam GJV, Deelder AM et al. Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis. American Journal of Tropical Medicine and Hygiene. 2008;79(3):331-337.
Erikstrup, C. ; Kallestrup, P. ; Zinyama-Gutsire, R.B. et al. / Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis. In: American Journal of Tropical Medicine and Hygiene. 2008 ; Vol. 79, No. 3. pp. 331-337.
@article{4a7c3d9005d611deb05e000ea68e967b,
title = "Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis",
abstract = "We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation Udgivelsesdato: 2008/9",
author = "C. Erikstrup and P. Kallestrup and R.B. Zinyama-Gutsire and E. Gomo and Dam, {G.J. van} and A.M. Deelder and A.E. Butterworth and Pedersen, {Bente Klarlund} and S.R. Ostrowski and J. Gerstoft and H. Ullum",
year = "2008",
language = "English",
volume = "79",
pages = "331--337",
journal = "American Journal of Tropical Medicine and Hygiene",
issn = "0002-9637",
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T1 - Schistosomiasis and infection with human immunodeficiency virus 1 in rural Zimbabwe: systemic inflammation during co-infection and after treatment for schistosomiasis
AU - Erikstrup, C.
AU - Kallestrup, P.
AU - Zinyama-Gutsire, R.B.
AU - Gomo, E.
AU - Dam, G.J. van
AU - Deelder, A.M.
AU - Butterworth, A.E.
AU - Pedersen, Bente Klarlund
AU - Ostrowski, S.R.
AU - Gerstoft, J.
AU - Ullum, H.
PY - 2008
Y1 - 2008
N2 - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation
Udgivelsesdato: 2008/9
AB - We previously reported that treatment for schistosomiasis in persons infected with human immunodeficiency virus 1 (HIV-1) attenuated HIV replication as measured by plasma HIV RNA. We investigated systemic inflammation as measured by plasma levels of soluble tumor necrosis factor-alpha receptor II (sTNF-rII), interleukin-8, (IL-8), and IL-10 during schistosomiasis and HIV co-infection and after schistosomiasis treatment. The cohort was composed of 378 persons who were or were not infected with HIV-1, Schistosoma haematobium, or S. mansoni. Schistosomiasis-infected persons were randomized to receive praziquantel (40 mg/kg) at baseline or at the three-month follow-up. sTNF-rII and IL-8 were positively associated with schistosomiasis intensity as measured by circulating anodic antigen (CAA), regardless of HIV status. Interleukin-10 was positively associated with CAA in HIV-negative participants. IL-8 levels were higher in S. mansoni-infected individuals. Treatment for schistosomiasis caused a decrease in levels of sTNF-rII (P < 0.05) and IL-10 (P < 0.001). Our results indicate that schistosomiasis treatment may attenuate HIV replication by decreasing systemic inflammation
Udgivelsesdato: 2008/9
M3 - Journal article
SN - 0002-9637
VL - 79
SP - 331
EP - 337
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
IS - 3
ER -
