Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

Dong-Chan Oh; Michael Poulsen; Cameron R Currie; Jon Clardy

doi:10.1021/ol102991d

Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

Dong-Chan Oh, Michael Poulsen, Cameron R Currie, Jon Clardy

Ecology and Evolution

62 Citations (Scopus)

Abstract

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 µg/mL, 8.3 µM).

Original language	English
Journal	Organic Letters
Volume	13
Issue number	4
Pages (from-to)	752-755
Number of pages	4
ISSN	1523-7060
DOIs	https://doi.org/10.1021/ol102991d
Publication status	Published - 18 Feb 2011

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title = "Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp",

abstract = "A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 µg/mL, 8.3 µM).",

author = "Dong-Chan Oh and Michael Poulsen and Currie, {Cameron R} and Jon Clardy",

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T1 - Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

AU - Oh, Dong-Chan

AU - Poulsen, Michael

AU - Currie, Cameron R

AU - Clardy, Jon

PY - 2011/2/18

Y1 - 2011/2/18

N2 - A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 µg/mL, 8.3 µM).

AB - A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 µg/mL, 8.3 µM).

U2 - 10.1021/ol102991d

DO - 10.1021/ol102991d

M3 - Journal article

C2 - 21247188

SN - 1523-7060

VL - 13

SP - 752

EP - 755

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp

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