Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort

Jiri Bartek; Christian Laugesen; Sadia Mirza; Axel Forsse; Michael Anders Petersen; Alba Corell; Philip Wilhelm Dyhrfort; Henrietta Nittby Redebrandt; Linus Reen; Shaian Zolfaghari; Lovisa Tobieson; Björn Carlsvärd; Bo Bergholt; Asma Bashir; Preben Soerensen; Arzu Bilgin; Conny Johansson; Peter Lindvall; Petter Förander; Bo-Michael Bellander; Jacob B Springborg; Asgeir S Jakola

doi:10.1093/neuros/nyy173

Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort

Jiri Bartek, Christian Laugesen, Sadia Mirza, Axel Forsse, Michael Anders Petersen, Alba Corell, Philip Wilhelm Dyhrfort, Henrietta Nittby Redebrandt, Linus Reen, Shaian Zolfaghari, Lovisa Tobieson, Björn Carlsvärd, Bo Bergholt, Asma Bashir, Preben Soerensen, Arzu Bilgin, Conny Johansson, Peter Lindvall, Petter Förander, Bo-Michael BellanderJacob B Springborg, Asgeir S Jakola

Department of Clinical Medicine

1 Citation (Scopus)

Abstract

BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.

OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.

METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.

EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.

DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.

Original language	English
Journal	Neurosurgery
Volume	84
Issue number	3
Pages (from-to)	799-803
ISSN	0148-396X
DOIs	https://doi.org/10.1093/neuros/nyy173
Publication status	Published - 1 Mar 2019

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Bartek, J., Laugesen, C., Mirza, S., Forsse, A., Petersen, M. A., Corell, A., Dyhrfort, P. W., Redebrandt, H. N., Reen, L., Zolfaghari, S., Tobieson, L., Carlsvärd, B., Bergholt, B., Bashir, A., Soerensen, P., Bilgin, A., Johansson, C., Lindvall, P., Förander, P., ... Jakola, A. S. (2019). Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort. Neurosurgery, 84(3), 799-803. https://doi.org/10.1093/neuros/nyy173

Bartek, J, Laugesen, C, Mirza, S, Forsse, A, Petersen, MA, Corell, A, Dyhrfort, PW, Redebrandt, HN, Reen, L, Zolfaghari, S, Tobieson, L, Carlsvärd, B, Bergholt, B, Bashir, A, Soerensen, P, Bilgin, A, Johansson, C, Lindvall, P, Förander, P, Bellander, B-M, Springborg, JB & Jakola, AS 2019, 'Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort', Neurosurgery, vol. 84, no. 3, pp. 799-803. https://doi.org/10.1093/neuros/nyy173

@article{a48c39a1d33e4bc187c069f08cbf8c5c,

title = "Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort",

abstract = "BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.",

author = "Jiri Bartek and Christian Laugesen and Sadia Mirza and Axel Forsse and Petersen, {Michael Anders} and Alba Corell and Dyhrfort, {Philip Wilhelm} and Redebrandt, {Henrietta Nittby} and Linus Reen and Shaian Zolfaghari and Lovisa Tobieson and Bj{\"o}rn Carlsv{\"a}rd and Bo Bergholt and Asma Bashir and Preben Soerensen and Arzu Bilgin and Conny Johansson and Peter Lindvall and Petter F{\"o}rander and Bo-Michael Bellander and Springborg, {Jacob B} and Jakola, {Asgeir S}",

note = "Copyright {\textcopyright} 2018 by the Congress of Neurological Surgeons.",

year = "2019",

month = mar,

day = "1",

doi = "10.1093/neuros/nyy173",

language = "English",

volume = "84",

pages = "799--803",

journal = "Neurosurgery",

issn = "0148-396X",

publisher = "Lippincott Williams & Wilkins",

number = "3",

}

TY - JOUR

T1 - Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study

T2 - Study Protocol for a Multinational Population-Based Consecutive Cohort

AU - Bartek, Jiri

AU - Laugesen, Christian

AU - Mirza, Sadia

AU - Forsse, Axel

AU - Petersen, Michael Anders

AU - Corell, Alba

AU - Dyhrfort, Philip Wilhelm

AU - Redebrandt, Henrietta Nittby

AU - Reen, Linus

AU - Zolfaghari, Shaian

AU - Tobieson, Lovisa

AU - Carlsvärd, Björn

AU - Bergholt, Bo

AU - Bashir, Asma

AU - Soerensen, Preben

AU - Bilgin, Arzu

AU - Johansson, Conny

AU - Lindvall, Peter

AU - Förander, Petter

AU - Bellander, Bo-Michael

AU - Springborg, Jacob B

AU - Jakola, Asgeir S

PY - 2019/3/1

Y1 - 2019/3/1

N2 - BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.

AB - BACKGROUND: Traumatic acute subdural hematomas (ASDHs) are associated with high rate of morbidity and mortality, especially in elderly individuals. However, recent reports indicate that the morbidity and mortality rates might have improved.OBJECTIVE: To evaluate postoperative (30-d) mortality in younger vs elderly (≥70 yr) patients with ASDH. Comparing younger and elderly patients, the secondary objectives are morbidity patterns of care and 6 mo outcome according to Glasgow outcome scale (GOS). Finally, in patients with traumatic ASDH, we aim to provide prognostic variables.METHODS: This is a large-scale population-based Scandinavian study including all neurosurgical departments in Denmark and Sweden. All adult (≥18 yr) patients surgically treated between 2010 and 2014 for a traumatic ASDH in Denmark and Sweden will be included. Identification at clinicaltrials.gov is NCT03284190.EXPECTED OUTCOMES: We expect to provide data on potential differences between younger vs elderly patients in terms of mortality and morbidity. We hypothesize that elderly patients selected for surgery have a similar pattern of care as compared with younger patients. We will provide functional outcome in terms of GOS at 6 mo in younger vs elderly patients undergoing ASDH evacuation. Finally, clinical useful prognostic factors for favorable (GOS 4-5) vs unfavorable (GOS 1-3) will be identified.DISCUSSION: An improved understanding of the clinical outcome, treatment and resource allocation, clinical course, and the prognostic factors of traumatic ASDH will allow neurosurgeons to make better treatment decisions.

U2 - 10.1093/neuros/nyy173

DO - 10.1093/neuros/nyy173

M3 - Journal article

C2 - 29762769

SN - 0148-396X

VL - 84

SP - 799

EP - 803

JO - Neurosurgery

JF - Neurosurgery

IS - 3

ER -

Scandinavian Multicenter Acute Subdural Hematoma (SMASH) Study: Study Protocol for a Multinational Population-Based Consecutive Cohort

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