Sarcopenia and body composition in diabetic Charcot osteoarthropathy

Rasmus Bo Jansen; Tomas Møller Christensen; Jens Bülow; Lene Rørdam; Per E. Holstein; Ole Lander Svendsen

doi:10.1016/j.jdiacomp.2015.05.020

Sarcopenia and body composition in diabetic Charcot osteoarthropathy

Rasmus Bo Jansen, Tomas Møller Christensen, Jens Bülow, Lene Rørdam, Per E. Holstein, Ole Lander Svendsen

2 Citations (Scopus)

Abstract

BACKGROUND: Treatment of Charcot osteoarthropathy (COA) requires restricted walking and offloading for several months, which lead to fat re-distribution and increased sarcopenia.

OBJECTIVES/AIM: To investigate whether subjects with COA have an altered body composition compared to controls.

METHODS: Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal/total body fat distribution ratios.

RESULTS: Sarcopenia frequency was higher in the total population with diabetes overall (9-40%), compared to normal materials. Using two different models for correlating appendicular lean mass to sarcopenia, there were no differences in sarcopenia-rates between the groups (P=0.413 and 0.948 respectively). There was no significant difference in lean tissue mass between the affected and the unaffected leg in the immobilised subject group (P=0.830). The average fat percentage was (29.4-37.7%) in the population with diabetes, compared to a matching background population (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups.

CONCLUSION: To our knowledge, this is the first published dataset investigating body composition in subjects with Charcot osteoarthropathy. The study population of diabetics were more fat and sarcopenic than normal subjects, whereas no statistically significant impact of Charcot osteoarthropathy was found.

Original language	English
Journal	Journal of Diabetes and its Complications
Volume	29
Issue number	7
Pages (from-to)	937-942
Number of pages	6
ISSN	1056-8727
DOIs	https://doi.org/10.1016/j.jdiacomp.2015.05.020
Publication status	Published - 1 Sept 2015

Keywords

Absorptiometry, Photon
Adult
Age Distribution
Aged
Amyotrophic Lateral Sclerosis
Analysis of Variance
Body Composition
Body Mass Index
Case-Control Studies
Cohort Studies
Diabetes Mellitus
Female
Humans
Incidence
Male
Middle Aged
Osteoarthritis
Predictive Value of Tests
Prognosis
Reference Values
Sarcopenia
Severity of Illness Index
Sex Distribution

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jdiacomp.2015.05.020

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@article{441abfc334884b9f9970c1a99bef57ee,

title = "Sarcopenia and body composition in diabetic Charcot osteoarthropathy",

abstract = "BACKGROUND: Treatment of Charcot osteoarthropathy (COA) requires restricted walking and offloading for several months, which lead to fat re-distribution and increased sarcopenia.OBJECTIVES/AIM: To investigate whether subjects with COA have an altered body composition compared to controls.METHODS: Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal/total body fat distribution ratios.RESULTS: Sarcopenia frequency was higher in the total population with diabetes overall (9-40%), compared to normal materials. Using two different models for correlating appendicular lean mass to sarcopenia, there were no differences in sarcopenia-rates between the groups (P=0.413 and 0.948 respectively). There was no significant difference in lean tissue mass between the affected and the unaffected leg in the immobilised subject group (P=0.830). The average fat percentage was (29.4-37.7%) in the population with diabetes, compared to a matching background population (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups.CONCLUSION: To our knowledge, this is the first published dataset investigating body composition in subjects with Charcot osteoarthropathy. The study population of diabetics were more fat and sarcopenic than normal subjects, whereas no statistically significant impact of Charcot osteoarthropathy was found.",

keywords = "Absorptiometry, Photon, Adult, Age Distribution, Aged, Amyotrophic Lateral Sclerosis, Analysis of Variance, Body Composition, Body Mass Index, Case-Control Studies, Cohort Studies, Diabetes Mellitus, Female, Humans, Incidence, Male, Middle Aged, Osteoarthritis, Predictive Value of Tests, Prognosis, Reference Values, Sarcopenia, Severity of Illness Index, Sex Distribution",

author = "Jansen, {Rasmus Bo} and Christensen, {Tomas M{\o}ller} and Jens B{\"u}low and Lene R{\o}rdam and Holstein, {Per E.} and Svendsen, {Ole Lander}",

year = "2015",

month = sep,

day = "1",

doi = "10.1016/j.jdiacomp.2015.05.020",

language = "English",

volume = "29",

pages = "937--942",

journal = "Journal of Diabetes and its Complications",

issn = "1056-8727",

publisher = "Elsevier",

number = "7",

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TY - JOUR

T1 - Sarcopenia and body composition in diabetic Charcot osteoarthropathy

AU - Jansen, Rasmus Bo

AU - Christensen, Tomas Møller

AU - Bülow, Jens

AU - Rørdam, Lene

AU - Holstein, Per E.

AU - Svendsen, Ole Lander

PY - 2015/9/1

Y1 - 2015/9/1

N2 - BACKGROUND: Treatment of Charcot osteoarthropathy (COA) requires restricted walking and offloading for several months, which lead to fat re-distribution and increased sarcopenia.OBJECTIVES/AIM: To investigate whether subjects with COA have an altered body composition compared to controls.METHODS: Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal/total body fat distribution ratios.RESULTS: Sarcopenia frequency was higher in the total population with diabetes overall (9-40%), compared to normal materials. Using two different models for correlating appendicular lean mass to sarcopenia, there were no differences in sarcopenia-rates between the groups (P=0.413 and 0.948 respectively). There was no significant difference in lean tissue mass between the affected and the unaffected leg in the immobilised subject group (P=0.830). The average fat percentage was (29.4-37.7%) in the population with diabetes, compared to a matching background population (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups.CONCLUSION: To our knowledge, this is the first published dataset investigating body composition in subjects with Charcot osteoarthropathy. The study population of diabetics were more fat and sarcopenic than normal subjects, whereas no statistically significant impact of Charcot osteoarthropathy was found.

AB - BACKGROUND: Treatment of Charcot osteoarthropathy (COA) requires restricted walking and offloading for several months, which lead to fat re-distribution and increased sarcopenia.OBJECTIVES/AIM: To investigate whether subjects with COA have an altered body composition compared to controls.METHODS: Cross-sectional case-control study of people with diabetes with acute or chronic Charcot osteoarthropathy, matched with otherwise healthy people with diabetes. A total of 49 subjects (distribution ~1:1) had a total body DXA-scanning, measuring appendicular lean mass, android/gynoid and truncal/total body fat distribution ratios.RESULTS: Sarcopenia frequency was higher in the total population with diabetes overall (9-40%), compared to normal materials. Using two different models for correlating appendicular lean mass to sarcopenia, there were no differences in sarcopenia-rates between the groups (P=0.413 and 0.948 respectively). There was no significant difference in lean tissue mass between the affected and the unaffected leg in the immobilised subject group (P=0.830). The average fat percentage was (29.4-37.7%) in the population with diabetes, compared to a matching background population (24.5-31.9%), whereas there were no significant differences found between the groups (P=0.065). Neither truncal/total fat percent nor android/gynoid fat percent ratios showed differences between the groups.CONCLUSION: To our knowledge, this is the first published dataset investigating body composition in subjects with Charcot osteoarthropathy. The study population of diabetics were more fat and sarcopenic than normal subjects, whereas no statistically significant impact of Charcot osteoarthropathy was found.

KW - Absorptiometry, Photon

KW - Adult

KW - Age Distribution

KW - Aged

KW - Amyotrophic Lateral Sclerosis

KW - Analysis of Variance

KW - Body Composition

KW - Body Mass Index

KW - Case-Control Studies

KW - Cohort Studies

KW - Diabetes Mellitus

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Osteoarthritis

KW - Predictive Value of Tests

KW - Prognosis

KW - Reference Values

KW - Sarcopenia

KW - Severity of Illness Index

KW - Sex Distribution

U2 - 10.1016/j.jdiacomp.2015.05.020

DO - 10.1016/j.jdiacomp.2015.05.020

M3 - Journal article

C2 - 26139557

SN - 1056-8727

VL - 29

SP - 937

EP - 942

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

IS - 7

ER -

Sarcopenia and body composition in diabetic Charcot osteoarthropathy

Abstract

Keywords

UN SDGs

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