Salivary myoepithelial cells: an addendum

Asterios Triantafyllou; Lauge Hjorth Mikkelsen; Douglas R Gnepp; Simon Andreasen; Jennifer L Hunt; Kenneth O Devaney; Vincent Vander Poorten; Alessandra Rinaldo; Stefan M Willems; Alfio Ferlito

doi:10.1080/01913123.2018.1551259

Salivary myoepithelial cells: an addendum

Asterios Triantafyllou, Lauge Hjorth Mikkelsen, Douglas R Gnepp, Simon Andreasen, Jennifer L Hunt, Kenneth O Devaney, Vincent Vander Poorten, Alessandra Rinaldo, Stefan M Willems, Alfio Ferlito

1 Citation (Scopus)

Abstract

Salivary myoepithelial cells bear particular appendages and are involved in processes that have received incomplete attention in previous reviews. Here, cilia on myoepithelial cells are reviewed as regards substructure, occurrence, detection (electron microscopy, double immunofluorescence together with confocal microscopy), and roles (sensory reception, evolutionary homology, paracrine interaction). Attention is drawn to regressive changes affecting those cells (e.g. accumulation of lipofuscin), possible alterations of their cytoskeleton, internalization of apoptotic bodies and haemosiderin, and role in salivary microcalcification. The ability of differentiated salivary myoepithelial cells to divide is re-examined, particularly its increase in chronic inflammation and under experimental conditions. Caution with regard to histogenetic models of salivary neoplasia is re-emphasized; methodological deficiencies and areas of controversy are outlined; and lines of future research are suggested.

Original language	English
Journal	Ultrastructural Pathology
Volume	42
Issue number	6
Pages (from-to)	465-476
Number of pages	12
ISSN	0191-3123
DOIs	https://doi.org/10.1080/01913123.2018.1551259
Publication status	Published - 2 Nov 2018
Externally published	Yes

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title = "Salivary myoepithelial cells: an addendum",

abstract = "Salivary myoepithelial cells bear particular appendages and are involved in processes that have received incomplete attention in previous reviews. Here, cilia on myoepithelial cells are reviewed as regards substructure, occurrence, detection (electron microscopy, double immunofluorescence together with confocal microscopy), and roles (sensory reception, evolutionary homology, paracrine interaction). Attention is drawn to regressive changes affecting those cells (e.g. accumulation of lipofuscin), possible alterations of their cytoskeleton, internalization of apoptotic bodies and haemosiderin, and role in salivary microcalcification. The ability of differentiated salivary myoepithelial cells to divide is re-examined, particularly its increase in chronic inflammation and under experimental conditions. Caution with regard to histogenetic models of salivary neoplasia is re-emphasized; methodological deficiencies and areas of controversy are outlined; and lines of future research are suggested.",

author = "Asterios Triantafyllou and Mikkelsen, {Lauge Hjorth} and Gnepp, {Douglas R} and Simon Andreasen and Hunt, {Jennifer L} and Devaney, {Kenneth O} and {Vander Poorten}, Vincent and Alessandra Rinaldo and Willems, {Stefan M} and Alfio Ferlito",

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doi = "10.1080/01913123.2018.1551259",

language = "English",

volume = "42",

pages = "465--476",

journal = "Ultrastructural Pathology",

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TY - JOUR

T1 - Salivary myoepithelial cells

T2 - an addendum

AU - Triantafyllou, Asterios

AU - Mikkelsen, Lauge Hjorth

AU - Gnepp, Douglas R

AU - Andreasen, Simon

AU - Hunt, Jennifer L

AU - Devaney, Kenneth O

AU - Vander Poorten, Vincent

AU - Rinaldo, Alessandra

AU - Willems, Stefan M

AU - Ferlito, Alfio

PY - 2018/11/2

Y1 - 2018/11/2

N2 - Salivary myoepithelial cells bear particular appendages and are involved in processes that have received incomplete attention in previous reviews. Here, cilia on myoepithelial cells are reviewed as regards substructure, occurrence, detection (electron microscopy, double immunofluorescence together with confocal microscopy), and roles (sensory reception, evolutionary homology, paracrine interaction). Attention is drawn to regressive changes affecting those cells (e.g. accumulation of lipofuscin), possible alterations of their cytoskeleton, internalization of apoptotic bodies and haemosiderin, and role in salivary microcalcification. The ability of differentiated salivary myoepithelial cells to divide is re-examined, particularly its increase in chronic inflammation and under experimental conditions. Caution with regard to histogenetic models of salivary neoplasia is re-emphasized; methodological deficiencies and areas of controversy are outlined; and lines of future research are suggested.

AB - Salivary myoepithelial cells bear particular appendages and are involved in processes that have received incomplete attention in previous reviews. Here, cilia on myoepithelial cells are reviewed as regards substructure, occurrence, detection (electron microscopy, double immunofluorescence together with confocal microscopy), and roles (sensory reception, evolutionary homology, paracrine interaction). Attention is drawn to regressive changes affecting those cells (e.g. accumulation of lipofuscin), possible alterations of their cytoskeleton, internalization of apoptotic bodies and haemosiderin, and role in salivary microcalcification. The ability of differentiated salivary myoepithelial cells to divide is re-examined, particularly its increase in chronic inflammation and under experimental conditions. Caution with regard to histogenetic models of salivary neoplasia is re-emphasized; methodological deficiencies and areas of controversy are outlined; and lines of future research are suggested.

U2 - 10.1080/01913123.2018.1551259

DO - 10.1080/01913123.2018.1551259

M3 - Review

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SN - 0191-3123

VL - 42

SP - 465

EP - 476

JO - Ultrastructural Pathology

JF - Ultrastructural Pathology

IS - 6

ER -

Salivary myoepithelial cells: an addendum

Abstract

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