Abstract
Aim: To compare the salivary microbial profile in children with oral clefts to matched non-cleft controls in a cross-sectional study. Methods: The cleft group consisted of 80 children aged 5 years and 144 age-matched non-cleft children were recruited as a control group. Stimulated whole saliva samples were collected and analysed with checkerboard DNA–DNA hybridisation using 12 pre-determined bacterial probes. Background data on caries, oral hygiene, dietary habits and fluoride exposure were collected from clinical examinations and questionnaires. Results: Children in the cleft group had a significantly higher prevalence of dental caries but only minor differences in the salivary microbial profile were found. In general, the cleft-children displayed a lower prevalence of common commensal species (e.g. Streptococcus, Fusobacterium) when compared with the non-cleft controls. The differences were statistically significant (p < 0.05) but the clinical significance was unclear. Conclusions: The profile of the salivary microflora in 5-year-old children with and without oral clefts was basically similar and displayed only marginal differences with respect to commensal bacteria.
| Original language | English |
|---|---|
| Journal | European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry |
| Volume | 19 |
| Issue number | 1 |
| Pages (from-to) | 57-60 |
| Number of pages | 4 |
| ISSN | 1818-6300 |
| DOIs | |
| Publication status | Published - 1 Feb 2018 |
Keywords
- Child, Preschool
- Cleft Lip/complications
- Cleft Palate/complications
- Cross-Sectional Studies
- Dental Caries/epidemiology
- Female
- Humans
- Male
- Prevalence
- Saliva/microbiology
- Surveys and Questionnaires