Abstract
The prognosis of salivary gland carcinomas is difficult to assess. Simple mucin-type carbohydrates (T and sialosyl-T antigens, Tn and sialosyl-Tn antigens) have been shown to be of value in predicting prognosis for carcinomas in other locations. We studied the prognostic significance of the expression of these structures in a retrospective study of 133 patients with salivary gland carcinomas, using immunohistochemistry and a panel of well-defined monoclonal antibodies (MAbs) on formalin-fixed paraffin-embedded tissues. Sialosyl-Tn, T and sialosyl-T antigens were not correlated with prognosis. Univariate analyses showed no overall difference in survival or locoregional control between patients with Tn-positive and patients with Tn-negative tumours, but indicated that expression of the Tn antigen was associated with early locoregional recurrences and deaths. Tn was, however, not an independent prognostic factor by multivariate regression analysis.
| Original language | English |
|---|---|
| Journal | Oral Oncology |
| Volume | 34 |
| Issue number | 1 |
| Pages (from-to) | 44-51 |
| Number of pages | 8 |
| ISSN | 1368-8375 |
| Publication status | Published - Jan 1998 |
Keywords
- Adult
- Aged
- Aged, 80 and over
- Antigens, Tumor-Associated, Carbohydrate
- Female
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Mucins
- Prognosis
- Salivary Gland Neoplasms
- Survival Rate
- Tumor Markers, Biological