Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

Kristine Bjørndal; Annelise Krogdahl; Marianne Hamilton Therkildsen; Jens Overgaard; Jørgen Bjerregaard Johansen; Claus A Kristensen; Preben Homøe; Christian Hjort Sørensen; Elo Andersen; Troels Bundgaard; Hanne Primdahl; Karin Lambertsen; Lisbeth Juhler Andersen; Christian Godballe

doi:10.1016/j.oraloncology.2011.04.020

Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

Kristine Bjørndal, Annelise Krogdahl, Marianne Hamilton Therkildsen, Jens Overgaard, Jørgen Bjerregaard Johansen, Claus A Kristensen, Preben Homøe, Christian Hjort Sørensen, Elo Andersen, Troels Bundgaard, Hanne Primdahl, Karin Lambertsen, Lisbeth Juhler Andersen, Christian Godballe

128 Citations (Scopus)

Abstract

To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.

Original language	English
Journal	Oral Oncology
Volume	47
Issue number	7
Pages (from-to)	677-82
Number of pages	6
ISSN	1368-8375
DOIs	https://doi.org/10.1016/j.oraloncology.2011.04.020
Publication status	Published - Jul 2011

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10.1016/j.oraloncology.2011.04.020

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Bjørndal, K., Krogdahl, A., Therkildsen, M. H., Overgaard, J., Johansen, J. B., Kristensen, C. A., Homøe, P., Sørensen, C. H., Andersen, E., Bundgaard, T., Primdahl, H., Lambertsen, K., Andersen, L. J., & Godballe, C. (2011). Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncology, 47(7), 677-82. https://doi.org/10.1016/j.oraloncology.2011.04.020

Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA). / Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne Hamilton et al.

In: Oral Oncology, Vol. 47, No. 7, 07.2011, p. 677-82.

Research output: Contribution to journal › Journal article › Research › peer-review

Bjørndal, K, Krogdahl, A, Therkildsen, MH, Overgaard, J, Johansen, JB, Kristensen, CA, Homøe, P, Sørensen, CH, Andersen, E, Bundgaard, T, Primdahl, H, Lambertsen, K, Andersen, LJ & Godballe, C 2011, 'Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)', Oral Oncology, vol. 47, no. 7, pp. 677-82. https://doi.org/10.1016/j.oraloncology.2011.04.020

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abstract = "To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.",

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AU - Bjørndal, Kristine

AU - Krogdahl, Annelise

AU - Therkildsen, Marianne Hamilton

AU - Overgaard, Jens

AU - Johansen, Jørgen Bjerregaard

AU - Kristensen, Claus A

AU - Homøe, Preben

AU - Sørensen, Christian Hjort

AU - Andersen, Elo

AU - Bundgaard, Troels

AU - Primdahl, Hanne

AU - Lambertsen, Karin

AU - Andersen, Lisbeth Juhler

AU - Godballe, Christian

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N2 - To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.

AB - To describe the incidence, site and histology (WHO 2005) of salivary gland carcinomas in Denmark. Nine hundred and eighty-three patients diagnosed from 1990 to 2005 were identified from three nation-wide registries. The associated clinical data were retrospectively retrieved from patient medical records. Histological revision was performed in 886 cases (90%). Based on histological revision, 31 patients (3%) were excluded from the study leaving 952 for epidemiological analysis. The mean crude incidence in Denmark was 1.1/100,000/year. The male vs. female ratio was 0.97 and the median age was 62 years. The parotid gland was the most common site (52.5%) followed by the minor salivary glands of the oral cavity (26.3%). The most frequent histological subtypes were adenoid cystic carcinoma (25.2%), mucoepidermoid carcinoma (16.9%), adenocarcinoma NOS (12.2%) and acinic cell carcinoma (10.2%). The revision process changed the histological diagnosis in 121 out of 886 cases (14%). The incidence of salivary gland carcinoma in Denmark is higher than previously reported. More than half of salivary gland carcinomas are located in the parotid gland with adenoid cystic carcinoma being the most frequent subtype. Histological classification of salivary gland carcinomas is difficult and evaluation by dedicated pathology specialists might be essential for optimal diagnosis and treatment.

U2 - 10.1016/j.oraloncology.2011.04.020

DO - 10.1016/j.oraloncology.2011.04.020

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SN - 1741-9409

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JO - Oral Oncology Extra

JF - Oral Oncology Extra

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ER -

Salivary gland carcinoma in Denmark 1990-2005: a national study of incidence, site and histology. Results of the Danish Head and Neck Cancer Group (DAHANCA)

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