Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)

Kristine Bjørndal; Annelise Krogdahl; Marianne H Therkildsen; Birgitte Charabi; Claus A Kristensen; Elo Andersen; Sten Schytte; Hanne Primdahl; Jørgen Johansen; Henrik B. Pedersen; Lisbeth J Andersen; Christian Godballe

doi:10.1016/j.oraloncology.2015.10.002

Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)

Kristine Bjørndal, Annelise Krogdahl, Marianne H Therkildsen, Birgitte Charabi, Claus A Kristensen, Elo Andersen, Sten Schytte, Hanne Primdahl, Jørgen Johansen, Henrik B. Pedersen, Lisbeth J Andersen, Christian Godballe

Department of Clinical Medicine

45 Citations (Scopus)

Abstract

AIM: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas.

METHODS: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database.

RESULTS: The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year locoregional control rate was 70%, and 36% of patients experienced a recurrence during follow-up (median 7.5 years); 18% developed distant metastases (most commonly to the lungs). In multivariate analysis, stage and margin status were both important factors with regards to survival and locoregional control. Radiotherapy did not improve survival, but it did improve the locoregional control rate.

CONCLUSIONS: The treatment of choice is surgery with as wide margins as possible including elective, selective neck dissection. Adjuvant radiotherapy should be considered in patients with incomplete tumor resection, high disease stages, and tumors with a solid growth pattern.

Original language	English
Journal	Oral Oncology
Volume	51
Issue number	12
Pages (from-to)	1138-42
Number of pages	5
ISSN	1368-8375
DOIs	https://doi.org/10.1016/j.oraloncology.2015.10.002
Publication status	Published - Dec 2015

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10.1016/j.oraloncology.2015.10.002

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Bjørndal, K., Krogdahl, A., Therkildsen, M. H., Charabi, B., Kristensen, C. A., Andersen, E., Schytte, S., Primdahl, H., Johansen, J., Pedersen, H. B., Andersen, L. J., & Godballe, C. (2015). Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA). Oral Oncology, 51(12), 1138-42. https://doi.org/10.1016/j.oraloncology.2015.10.002

Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA). / Bjørndal, Kristine; Krogdahl, Annelise; Therkildsen, Marianne H et al.
In: Oral Oncology, Vol. 51, No. 12, 12.2015, p. 1138-42.

Research output: Contribution to journal › Journal article › Research › peer-review

Bjørndal, K, Krogdahl, A, Therkildsen, MH, Charabi, B, Kristensen, CA, Andersen, E, Schytte, S, Primdahl, H, Johansen, J, Pedersen, HB, Andersen, LJ & Godballe, C 2015, 'Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)', Oral Oncology, vol. 51, no. 12, pp. 1138-42. https://doi.org/10.1016/j.oraloncology.2015.10.002

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title = "Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)",

abstract = "AIM: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas.METHODS: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database.RESULTS: The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year locoregional control rate was 70%, and 36% of patients experienced a recurrence during follow-up (median 7.5 years); 18% developed distant metastases (most commonly to the lungs). In multivariate analysis, stage and margin status were both important factors with regards to survival and locoregional control. Radiotherapy did not improve survival, but it did improve the locoregional control rate.CONCLUSIONS: The treatment of choice is surgery with as wide margins as possible including elective, selective neck dissection. Adjuvant radiotherapy should be considered in patients with incomplete tumor resection, high disease stages, and tumors with a solid growth pattern.",

author = "Kristine Bj{\o}rndal and Annelise Krogdahl and Therkildsen, {Marianne H} and Birgitte Charabi and Kristensen, {Claus A} and Elo Andersen and Sten Schytte and Hanne Primdahl and J{\o}rgen Johansen and Pedersen, {Henrik B.} and Andersen, {Lisbeth J} and Christian Godballe",

year = "2015",

month = dec,

doi = "10.1016/j.oraloncology.2015.10.002",

language = "English",

volume = "51",

pages = "1138--42",

journal = "Oral Oncology",

issn = "1368-8375",

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TY - JOUR

T1 - Salivary adenoid cystic carcinoma in Denmark 1990-2005

T2 - Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)

AU - Bjørndal, Kristine

AU - Krogdahl, Annelise

AU - Therkildsen, Marianne H

AU - Charabi, Birgitte

AU - Kristensen, Claus A

AU - Andersen, Elo

AU - Schytte, Sten

AU - Primdahl, Hanne

AU - Johansen, Jørgen

AU - Pedersen, Henrik B.

AU - Andersen, Lisbeth J

AU - Godballe, Christian

PY - 2015/12

Y1 - 2015/12

N2 - AIM: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas.METHODS: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database.RESULTS: The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year locoregional control rate was 70%, and 36% of patients experienced a recurrence during follow-up (median 7.5 years); 18% developed distant metastases (most commonly to the lungs). In multivariate analysis, stage and margin status were both important factors with regards to survival and locoregional control. Radiotherapy did not improve survival, but it did improve the locoregional control rate.CONCLUSIONS: The treatment of choice is surgery with as wide margins as possible including elective, selective neck dissection. Adjuvant radiotherapy should be considered in patients with incomplete tumor resection, high disease stages, and tumors with a solid growth pattern.

AB - AIM: To describe outcome and prognostic factors, including the effect of radiotherapy, in a consecutive national series of salivary gland adenoid cystic carcinomas.METHODS: From the national Danish salivary gland carcinoma database in the structure of DAHANCA, 201 patients diagnosed with adenoid cystic carcinoma, and treated with a curative intent, were identified in the period between 1990 and 2005. Variables necessary for statistical analyses were extracted from the database.RESULTS: The 10-year crude survival and disease specific survival rates were 58% and 75%, respectively. The 10-year locoregional control rate was 70%, and 36% of patients experienced a recurrence during follow-up (median 7.5 years); 18% developed distant metastases (most commonly to the lungs). In multivariate analysis, stage and margin status were both important factors with regards to survival and locoregional control. Radiotherapy did not improve survival, but it did improve the locoregional control rate.CONCLUSIONS: The treatment of choice is surgery with as wide margins as possible including elective, selective neck dissection. Adjuvant radiotherapy should be considered in patients with incomplete tumor resection, high disease stages, and tumors with a solid growth pattern.

U2 - 10.1016/j.oraloncology.2015.10.002

DO - 10.1016/j.oraloncology.2015.10.002

M3 - Journal article

C2 - 26476712

SN - 1368-8375

VL - 51

SP - 1138

EP - 1142

JO - Oral Oncology

JF - Oral Oncology

IS - 12

ER -

Salivary adenoid cystic carcinoma in Denmark 1990-2005: Outcome and independent prognostic factors including the benefit of radiotherapy. Results of the Danish Head and Neck Cancer Group (DAHANCA)

Abstract

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