Safety and feasibility of home-based chemotherapy

Finn Ole Larsen; Anne Birgitte Christiansen; Anette Rishøj; Knud Mejer Nelausen; Dorte L Nielsen

Safety and feasibility of home-based chemotherapy

Finn Ole Larsen, Anne Birgitte Christiansen, Anette Rishøj, Knud Mejer Nelausen, Dorte L Nielsen

Department of Clinical Medicine

5 Citations (Scopus)

9 Downloads (Pure)

Abstract

INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient’s preference. METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic. Patients with adverse events graded ≤ 2 on the Common Terminology Criteria for Adverse Events version 3.0 were randomised to either group A continuing with four treatments at home followed by three in an outpatient clinic, or to group B continuing with three treatments in an outpatient clinic followed by four at home. To assess quality of life, the EuroQol-5 Domain was used at baseline and before each treatment. Preference cards were used at baseline and at end of treatment. RESULTS: A total of 51 patients were included between 2007 and 2010. Forty-two patients continued in either group A or B. The nurse found that the treatment was safe and acceptable in all cases. In 145 cycles (99.3%), patients answered that they felt secure; only one patient answered: “Do not know”. The highest-ranking preferences for patients were transportation time followed by waiting time. CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic.

Original language	English
Article number	A5482
Journal	Danish Medical Journal
Volume	65
Issue number	5
Number of pages	5
ISSN	1603-9629
Publication status	Published - May 2018

Keywords

Adult
Aged
Aged, 80 and over
Ambulatory Care Facilities
Capecitabine/administration & dosage
Chemotherapy, Adjuvant/adverse effects
Colonic Neoplasms/drug therapy
Cross-Over Studies
Feasibility Studies
Female
Home Care Services
Humans
Linear Models
Male
Middle Aged
Organoplatinum Compounds/administration & dosage
Oxaliplatin
Patient Preference
Patient Safety
Quality of Life

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Safety and feasibility of home-based chemotherapy",

abstract = "INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient{\textquoteright}s preference. METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic. Patients with adverse events graded ≤ 2 on the Common Terminology Criteria for Adverse Events version 3.0 were randomised to either group A continuing with four treatments at home followed by three in an outpatient clinic, or to group B continuing with three treatments in an outpatient clinic followed by four at home. To assess quality of life, the EuroQol-5 Domain was used at baseline and before each treatment. Preference cards were used at baseline and at end of treatment. RESULTS: A total of 51 patients were included between 2007 and 2010. Forty-two patients continued in either group A or B. The nurse found that the treatment was safe and acceptable in all cases. In 145 cycles (99.3%), patients answered that they felt secure; only one patient answered: “Do not know”. The highest-ranking preferences for patients were transportation time followed by waiting time. CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic.",

keywords = "Adult, Aged, Aged, 80 and over, Ambulatory Care Facilities, Capecitabine/administration & dosage, Chemotherapy, Adjuvant/adverse effects, Colonic Neoplasms/drug therapy, Cross-Over Studies, Feasibility Studies, Female, Home Care Services, Humans, Linear Models, Male, Middle Aged, Organoplatinum Compounds/administration & dosage, Oxaliplatin, Patient Preference, Patient Safety, Quality of Life",

author = "Larsen, {Finn Ole} and Christiansen, {Anne Birgitte} and Anette Rish{\o}j and Nelausen, {Knud Mejer} and Nielsen, {Dorte L}",

note = "Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.",

year = "2018",

month = may,

language = "English",

volume = "65",

journal = "Danish Medical Journal",

issn = "1603-9629",

publisher = "Almindelige Danske Laegeforening",

number = "5",

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TY - JOUR

T1 - Safety and feasibility of home-based chemotherapy

AU - Larsen, Finn Ole

AU - Christiansen, Anne Birgitte

AU - Rishøj, Anette

AU - Nelausen, Knud Mejer

AU - Nielsen, Dorte L

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2018/5

Y1 - 2018/5

N2 - INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient’s preference. METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic. Patients with adverse events graded ≤ 2 on the Common Terminology Criteria for Adverse Events version 3.0 were randomised to either group A continuing with four treatments at home followed by three in an outpatient clinic, or to group B continuing with three treatments in an outpatient clinic followed by four at home. To assess quality of life, the EuroQol-5 Domain was used at baseline and before each treatment. Preference cards were used at baseline and at end of treatment. RESULTS: A total of 51 patients were included between 2007 and 2010. Forty-two patients continued in either group A or B. The nurse found that the treatment was safe and acceptable in all cases. In 145 cycles (99.3%), patients answered that they felt secure; only one patient answered: “Do not know”. The highest-ranking preferences for patients were transportation time followed by waiting time. CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic.

AB - INTRODUCTION: The purpose of this study was to evaluate the safety and feasibility of home-based chemotherapy and to compare chemotherapy given at home with chemotherapy given as an outpatient treatment in relation to toxicity, quality of life and patient’s preference. METHODS: Patients who had undergone radical surgery for colon cancer and who were eligible to receive adjuvant treatment with capecitabine and oxaliplatin could be included. To ensure patient safety, the first infusion was given at an outpatient clinic. Patients with adverse events graded ≤ 2 on the Common Terminology Criteria for Adverse Events version 3.0 were randomised to either group A continuing with four treatments at home followed by three in an outpatient clinic, or to group B continuing with three treatments in an outpatient clinic followed by four at home. To assess quality of life, the EuroQol-5 Domain was used at baseline and before each treatment. Preference cards were used at baseline and at end of treatment. RESULTS: A total of 51 patients were included between 2007 and 2010. Forty-two patients continued in either group A or B. The nurse found that the treatment was safe and acceptable in all cases. In 145 cycles (99.3%), patients answered that they felt secure; only one patient answered: “Do not know”. The highest-ranking preferences for patients were transportation time followed by waiting time. CONCLUSIONS: Our study demonstrates that home-based chemotherapy is feasible and safe and that it might be a valuable alternative to treatment at an outpatient clinic.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Ambulatory Care Facilities

KW - Capecitabine/administration & dosage

KW - Chemotherapy, Adjuvant/adverse effects

KW - Colonic Neoplasms/drug therapy

KW - Cross-Over Studies

KW - Feasibility Studies

KW - Female

KW - Home Care Services

KW - Humans

KW - Linear Models

KW - Male

KW - Middle Aged

KW - Organoplatinum Compounds/administration & dosage

KW - Oxaliplatin

KW - Patient Preference

KW - Patient Safety

KW - Quality of Life

M3 - Journal article

C2 - 29726319

SN - 1603-9629

VL - 65

JO - Danish Medical Journal

JF - Danish Medical Journal

IS - 5

M1 - A5482

ER -

Safety and feasibility of home-based chemotherapy

Abstract

Keywords

UN SDGs

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