ROS and myokines promote muscle adaptation to exercise

Camilla Scheele; Søren Nielsen; Bente K Pedersen

doi:10.1016/j.tem.2008.12.002

ROS and myokines promote muscle adaptation to exercise

Camilla Scheele, Søren Nielsen, Bente K Pedersen

87 Citations (Scopus)

Abstract

Physical exercise induces a network of alterations in the transcriptome and proteome of the skeletal muscle, resulting in modifications of the muscle physiology. Intriguingly, exercise also transiently induces the production of both reactive oxygen species (ROS) and some inflammatory cytokines in skeletal muscle. In fact, it seems that exercise-induced ROS are able to stimulate cytokine production from skeletal muscle. Despite the initial view that ROS were potentially cell damaging, it now seems possible that these substances have important roles in the regulation of cell signaling. Muscle-derived cytokines, so-called 'myokines', are distinguished from inflammation and instead possess important anti-inflammatory and metabolic properties. In this opinion piece, we suggest that both ROS and myokines are important players in muscle adaptation to exercise.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	20
Issue number	3
Pages (from-to)	95-9
Number of pages	4
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2008.12.002
Publication status	Published - 2009

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10.1016/j.tem.2008.12.002

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title = "ROS and myokines promote muscle adaptation to exercise",

abstract = "Physical exercise induces a network of alterations in the transcriptome and proteome of the skeletal muscle, resulting in modifications of the muscle physiology. Intriguingly, exercise also transiently induces the production of both reactive oxygen species (ROS) and some inflammatory cytokines in skeletal muscle. In fact, it seems that exercise-induced ROS are able to stimulate cytokine production from skeletal muscle. Despite the initial view that ROS were potentially cell damaging, it now seems possible that these substances have important roles in the regulation of cell signaling. Muscle-derived cytokines, so-called 'myokines', are distinguished from inflammation and instead possess important anti-inflammatory and metabolic properties. In this opinion piece, we suggest that both ROS and myokines are important players in muscle adaptation to exercise.",

author = "Camilla Scheele and S{\o}ren Nielsen and Pedersen, {Bente K}",

note = "Keywords: Animals; Cytokines; Exercise; Humans; Models, Biological; Muscle, Skeletal; Reactive Oxygen Species; Signal Transduction",

year = "2009",

doi = "10.1016/j.tem.2008.12.002",

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journal = "Trends in Endocrinology and Metabolism",

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TY - JOUR

T1 - ROS and myokines promote muscle adaptation to exercise

AU - Scheele, Camilla

AU - Nielsen, Søren

AU - Pedersen, Bente K

N1 - Keywords: Animals; Cytokines; Exercise; Humans; Models, Biological; Muscle, Skeletal; Reactive Oxygen Species; Signal Transduction

PY - 2009

Y1 - 2009

N2 - Physical exercise induces a network of alterations in the transcriptome and proteome of the skeletal muscle, resulting in modifications of the muscle physiology. Intriguingly, exercise also transiently induces the production of both reactive oxygen species (ROS) and some inflammatory cytokines in skeletal muscle. In fact, it seems that exercise-induced ROS are able to stimulate cytokine production from skeletal muscle. Despite the initial view that ROS were potentially cell damaging, it now seems possible that these substances have important roles in the regulation of cell signaling. Muscle-derived cytokines, so-called 'myokines', are distinguished from inflammation and instead possess important anti-inflammatory and metabolic properties. In this opinion piece, we suggest that both ROS and myokines are important players in muscle adaptation to exercise.

AB - Physical exercise induces a network of alterations in the transcriptome and proteome of the skeletal muscle, resulting in modifications of the muscle physiology. Intriguingly, exercise also transiently induces the production of both reactive oxygen species (ROS) and some inflammatory cytokines in skeletal muscle. In fact, it seems that exercise-induced ROS are able to stimulate cytokine production from skeletal muscle. Despite the initial view that ROS were potentially cell damaging, it now seems possible that these substances have important roles in the regulation of cell signaling. Muscle-derived cytokines, so-called 'myokines', are distinguished from inflammation and instead possess important anti-inflammatory and metabolic properties. In this opinion piece, we suggest that both ROS and myokines are important players in muscle adaptation to exercise.

U2 - 10.1016/j.tem.2008.12.002

DO - 10.1016/j.tem.2008.12.002

M3 - Journal article

C2 - 19269849

SN - 1043-2760

VL - 20

SP - 95

EP - 99

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 3

ER -

ROS and myokines promote muscle adaptation to exercise

Abstract

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