Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

Gerhard Fürstenberger; Nikolas Epp; Katja-Martina Eckl; Hans Christian Hennies; Philip Hallenborg; Karsten Kristiansen; Claus Jørgensen; Peter Krieg

doi:10.1016/j.prostaglandins.2006.05.006

Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

Gerhard Fürstenberger, Nikolas Epp, Katja-Martina Eckl, Hans Christian Hennies, Philip Hallenborg, Karsten Kristiansen, Claus Jørgensen, Peter Krieg

26 Citations (Scopus)

Abstract

12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

Original language	English
Journal	Prostaglandins & Other Lipid Mediators
Volume	82
Issue number	1-4
Pages (from-to)	128-34
Number of pages	6
ISSN	1098-8823
DOIs	https://doi.org/10.1016/j.prostaglandins.2006.05.006
Publication status	Published - 2007
Externally published	Yes

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10.1016/j.prostaglandins.2006.05.006

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@article{0d55c020f75411ddbf70000ea68e967b,

title = "Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation",

abstract = "12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.",

author = "Gerhard F{\"u}rstenberger and Nikolas Epp and Katja-Martina Eckl and Hennies, {Hans Christian} and Philip Hallenborg and Karsten Kristiansen and Claus J{\o}rgensen and Peter Krieg",

year = "2007",

doi = "10.1016/j.prostaglandins.2006.05.006",

language = "English",

volume = "82",

pages = "128--34",

journal = "Prostaglandins and Other Lipid Mediators",

issn = "1098-8823",

publisher = "Elsevier",

number = "1-4",

}

TY - JOUR

T1 - Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

AU - Fürstenberger, Gerhard

AU - Epp, Nikolas

AU - Eckl, Katja-Martina

AU - Hennies, Hans Christian

AU - Hallenborg, Philip

AU - Kristiansen, Karsten

AU - Jørgensen, Claus

AU - Krieg, Peter

PY - 2007

Y1 - 2007

N2 - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

AB - 12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

U2 - 10.1016/j.prostaglandins.2006.05.006

DO - 10.1016/j.prostaglandins.2006.05.006

M3 - Journal article

C2 - 17164140

SN - 1098-8823

VL - 82

SP - 128

EP - 134

JO - Prostaglandins and Other Lipid Mediators

JF - Prostaglandins and Other Lipid Mediators

IS - 1-4

ER -

Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation

Abstract

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