Role of autophagy in disease resistance and hypersensitive response-associated cell death

TY - JOUR

T1 - Role of autophagy in disease resistance and hypersensitive response-associated cell death

AU - Hofius, Daniel

AU - Munch, David

AU - Bressendorff, Simon

AU - Mundy, John

AU - Petersen, Morten

PY - 2011/8

Y1 - 2011/8

N2 - Ancient autophagy pathways are emerging as key defense modules in host eukaryotic cells against microbial pathogens. Apart from actively eliminating intracellular intruders, autophagy is also responsible for cell survival, for example by reducing the deleterious effects of endoplasmic reticulum stress. At the same time, autophagy can contribute to cellular suicide. The concurrent engagement of autophagy in these processes during infection may sometimes mask its contribution to differing pro-survival and pro-death decisions. The importance of autophagy in innate immunity in mammals is well documented, but how autophagy contributes to plant innate immunity and cell death is not that clear. A few research reports have appeared recently to shed light on the roles of autophagy in plant-pathogen interactions and in disease-associated host cell death. We present a first attempt to reconcile the results of this research.

AB - Ancient autophagy pathways are emerging as key defense modules in host eukaryotic cells against microbial pathogens. Apart from actively eliminating intracellular intruders, autophagy is also responsible for cell survival, for example by reducing the deleterious effects of endoplasmic reticulum stress. At the same time, autophagy can contribute to cellular suicide. The concurrent engagement of autophagy in these processes during infection may sometimes mask its contribution to differing pro-survival and pro-death decisions. The importance of autophagy in innate immunity in mammals is well documented, but how autophagy contributes to plant innate immunity and cell death is not that clear. A few research reports have appeared recently to shed light on the roles of autophagy in plant-pathogen interactions and in disease-associated host cell death. We present a first attempt to reconcile the results of this research.

KW - Animals

KW - Autophagy

KW - Cell Death

KW - Cell Survival

KW - Disease Resistance

KW - Host-Pathogen Interactions

KW - Plant Cells

KW - Plants

U2 - 10.1038/cdd.2011.43

DO - 10.1038/cdd.2011.43

M3 - Journal article

C2 - 21527936

SN - 1350-9047

VL - 18

SP - 1257

EP - 1262

JO - Cell Death and Differentiation

JF - Cell Death and Differentiation

IS - 8

ER -