Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

A Schousboe; A Sarup; L K Bak; H S Waagepetersen; O M Larsson

doi:10.1016/j.neuint.2003.11.001

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

A Schousboe, A Sarup, L K Bak, H S Waagepetersen, O M Larsson

111 Citations (Scopus)

Abstract

The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated.

Original language	English
Journal	Neurochemistry International
Volume	45
Issue number	4
Pages (from-to)	521-7
Number of pages	7
ISSN	0197-0186
DOIs	https://doi.org/10.1016/j.neuint.2003.11.001
Publication status	Published - Sept 2004

Keywords

Amino Acid Transport System X-AG
Animals
Astrocytes
Carrier Proteins
GABA Plasma Membrane Transport Proteins
Glutamates
Humans
Membrane Proteins
Membrane Transport Proteins
Synaptic Transmission
gamma-Aminobutyric Acid

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10.1016/j.neuint.2003.11.001

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title = "Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission",

abstract = "The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated.",

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T1 - Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

AU - Schousboe, A

AU - Sarup, A

AU - Bak, L K

AU - Waagepetersen, H S

AU - Larsson, O M

PY - 2004/9

Y1 - 2004/9

N2 - The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated.

AB - The fine tuning of both glutamatergic and GABAergic neurotransmission is to a large extent dependent upon optimal function of astrocytic transport processes. Thus, glutamate transport in astrocytes is mandatory to maintain extrasynaptic glutamate levels sufficiently low to prevent excitotoxic neuronal damage. In GABA synapses hyperactivity of astroglial GABA uptake may lead to diminished GABAergic inhibitory activity resulting in seizures. As a consequence of this the expression and functional activity of astrocytic glutamate and GABA transport is regulated in a number of ways at transcriptional, translational and post-translational levels. This opens for a number of therapeutic strategies by which the efficacy of excitatory and inhibitory neurotransmission may be manipulated.

KW - Amino Acid Transport System X-AG

KW - Animals

KW - Astrocytes

KW - Carrier Proteins

KW - GABA Plasma Membrane Transport Proteins

KW - Glutamates

KW - Humans

KW - Membrane Proteins

KW - Membrane Transport Proteins

KW - Synaptic Transmission

KW - gamma-Aminobutyric Acid

U2 - 10.1016/j.neuint.2003.11.001

DO - 10.1016/j.neuint.2003.11.001

M3 - Journal article

C2 - 15186918

SN - 0197-0186

VL - 45

SP - 521

EP - 527

JO - Neurochemistry International

JF - Neurochemistry International

IS - 4

ER -

Role of astrocytic transport processes in glutamatergic and GABAergic neurotransmission

Abstract

Keywords

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