Abstract
Background: Cancer-associated mortality is increased in psoriasis. However, little is known about the risk of less common cancers. Objective: We aimed to evaluate the risk of less common cancers in patients with psoriasis compared to persons without psoriasis using a nationwide cohort study. Methods: Between 1 January 2008 and 31 December 2012, we identified all Danish patients with a first-time hospital diagnosis of a less common cancer defined as <100 new cases/year/100.000 persons in Denmark. The primary endpoint was the occurrence of a diagnosis of cancer. Results: We included 4 361 869 individuals. Of these, 58 138 were classified as having psoriasis. After adjusting for age, sex, socio-economic status and healthcare consumption, we found significantly elevated hazard ratios for cancers of bone and cartilage (HR 4.97 [2.32–10.62], P < 0.0001) in patients with psoriasis on systemic treatment. Conclusion: We provide further evidence of an increased cancer of bone and cartilage risk in patients with psoriasis.
| Original language | English |
|---|---|
| Journal | Journal of the European Academy of Dermatology and Venereology : JEADV |
| Volume | 32 |
| Issue number | 4 |
| Pages (from-to) | 601-605 |
| ISSN | 0926-9959 |
| DOIs | |
| Publication status | Published - Apr 2018 |
Keywords
- Adult
- Cohort Studies
- Denmark/epidemiology
- Female
- Humans
- Male
- Middle Aged
- Neoplasms/classification
- Psoriasis/complications
- Risk Factors
