Risk of metabolic disorders in childless men: a population-based cohort study

TY - JOUR

T1 - Risk of metabolic disorders in childless men

T2 - a population-based cohort study

AU - Bungum, Ane Berger

AU - Glazer, Clara Helene

AU - Bonde, Jens Peter

AU - Nilsson, Peter M

AU - Giwercman, Aleksander

AU - Søgaard Tøttenborg, Sandra

N1 - © Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY. Published by BMJ.

PY - 2018/8/1

Y1 - 2018/8/1

N2 - OBJECTIVE: To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.DESIGN: A population-based cohort study.SETTING: Not applicable.PARTICIPANTS: 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.INTERVENTIONS: None.MAIN OUTCOME MEASURES: From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men.RESULTS: At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)).CONCLUSION: This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.

AB - OBJECTIVE: To study whether male childlessness is associated with an increased risk of metabolic disorders such as metabolic syndrome (MetS) and diabetes.DESIGN: A population-based cohort study.SETTING: Not applicable.PARTICIPANTS: 2572 men from the population-based Malmö Diet and Cancer Cardiovascular Cohort.INTERVENTIONS: None.MAIN OUTCOME MEASURES: From cross-sectional analyses, main outcome measures were ORs and 95% CIs for MetS and diabetes among childless men. In prospective analyses, HRs and 95% CI for diabetes among childless men.RESULTS: At baseline, in men with a mean age of 57 years, the prevalence of MetS was 26% and 22% among childless men and fathers, respectively. Similarly, we observed a higher prevalence of diabetes of 11% among childless men compared with 5% among fathers. In the cross-sectional adjusted analyses, childless men had a higher risk of MetS and diabetes, with ORs of 1.22 (95% CI 0.87 to 1.72) and 2.12 (95% CI 1.34 to 3.36) compared with fathers. In the prospective analysis, during a mean follow-up of 18.3 years, we did not see any increase in diabetes risk among childless men (HR 1.02 (0.76 to 1.37)).CONCLUSION: This study provides evidence of an association between male childlessness and a higher risk of MetS and diabetes. However, as these associations were found in cross-sectional analyses, reverse causation cannot be excluded.

U2 - 10.1136/bmjopen-2017-020293

DO - 10.1136/bmjopen-2017-020293

M3 - Journal article

C2 - 30121591

SN - 2044-6055

VL - 8

SP - 1

EP - 7

JO - BMJ Open

JF - BMJ Open

IS - 8

M1 - e020293

ER -