Risk of early-onset prostate cancer associated with occupation in the Nordic countries

Kathryn Hughes Barry; Jan Ivar Martinsen; Michael C. R. Alavanja; Gabriella Andreotti; Aaron Blair; Johnni Hansen; Kristina Kjærheim; Stella Koutros; Elsebeth Lynge; Pär Sparèn; Laufey Tryggvadottir; Elisabete Weiderpass; Sonja I. Berndt; Eero Pukkala

doi:10.1016/j.ejca.2017.09.023

Risk of early-onset prostate cancer associated with occupation in the Nordic countries

Kathryn Hughes Barry, Jan Ivar Martinsen, Michael C. R. Alavanja, Gabriella Andreotti, Aaron Blair, Johnni Hansen, Kristina Kjærheim, Stella Koutros, Elsebeth Lynge, Pär Sparèn, Laufey Tryggvadottir, Elisabete Weiderpass, Sonja I. Berndt, Eero Pukkala

Center of Epidemiology and Screening

10 Citations (Scopus)

Abstract

BACKGROUND: Early-onset prostate cancer is often more aggressive and may have a different aetiology than later-onset prostate cancer, but has been relatively little studied to date. We evaluated occupation in relation to early- and later-onset prostate cancer in a large pooled study.

METHODS: We used occupational information from census data in five Nordic countries from 1960 to 1990. We identified prostate cancer cases diagnosed from 1961 to 2005 by linkage of census information to national cancer registries and calculated standardised incidence ratios (SIRs) separately for men aged 30-49 and those aged 50 or older. We also conducted separate analyses by period of follow-up, 1961-1985 and 1986-2005, corresponding to pre- and post-prostate-specific antigen (PSA) screening.

RESULTS: For early-onset prostate cancer (n = 1521), we observed the highest SIRs for public safety workers (e.g. firefighters) (SIR = 1.71, 95% confidence interval [CI]: 1.23-2.31) and military personnel (SIR = 1.97, 95% CI: 1.31-2.85). These SIRs were significantly higher than the SIRs for later-onset disease (for public safety workers, SIR = 1.10, 95% CI: 1.07-1.14 and for military personnel, SIR = 1.09, 95% CI: 1.05-1.13; pheterogeneity = 0.005 and 0.002, respectively). Administrators and technical workers also demonstrated significantly increased risks for early-onset prostate cancer, but the SIRs did not differ from those of later-onset disease (pheterogeneity >0.05). While our early-onset finding for public safety workers was restricted to the post-PSA period, that for military personnel was restricted to the pre-PSA period.

CONCLUSION: Our results suggest that occupational exposures, particularly for military personnel, may be associated with early-onset prostate cancer. Further evaluation is needed to explain these findings.

Original language	English
Journal	European Journal of Cancer
Volume	87
Pages (from-to)	92-100
Number of pages	9
ISSN	0959-8049
DOIs	https://doi.org/10.1016/j.ejca.2017.09.023
Publication status	Published - Dec 2017

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ejca.2017.09.023

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Hughes Barry, K., Martinsen, J. I., Alavanja, M. C. R., Andreotti, G., Blair, A., Hansen, J., Kjærheim, K., Koutros, S., Lynge, E., Sparèn, P., Tryggvadottir, L., Weiderpass, E., Berndt, S. I., & Pukkala, E. (2017). Risk of early-onset prostate cancer associated with occupation in the Nordic countries. European Journal of Cancer, 87, 92-100. https://doi.org/10.1016/j.ejca.2017.09.023

Hughes Barry, K, Martinsen, JI, Alavanja, MCR, Andreotti, G, Blair, A, Hansen, J, Kjærheim, K, Koutros, S, Lynge, E, Sparèn, P, Tryggvadottir, L, Weiderpass, E, Berndt, SI & Pukkala, E 2017, 'Risk of early-onset prostate cancer associated with occupation in the Nordic countries', European Journal of Cancer, vol. 87, pp. 92-100. https://doi.org/10.1016/j.ejca.2017.09.023

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abstract = "BACKGROUND: Early-onset prostate cancer is often more aggressive and may have a different aetiology than later-onset prostate cancer, but has been relatively little studied to date. We evaluated occupation in relation to early- and later-onset prostate cancer in a large pooled study.METHODS: We used occupational information from census data in five Nordic countries from 1960 to 1990. We identified prostate cancer cases diagnosed from 1961 to 2005 by linkage of census information to national cancer registries and calculated standardised incidence ratios (SIRs) separately for men aged 30-49 and those aged 50 or older. We also conducted separate analyses by period of follow-up, 1961-1985 and 1986-2005, corresponding to pre- and post-prostate-specific antigen (PSA) screening.RESULTS: For early-onset prostate cancer (n = 1521), we observed the highest SIRs for public safety workers (e.g. firefighters) (SIR = 1.71, 95% confidence interval [CI]: 1.23-2.31) and military personnel (SIR = 1.97, 95% CI: 1.31-2.85). These SIRs were significantly higher than the SIRs for later-onset disease (for public safety workers, SIR = 1.10, 95% CI: 1.07-1.14 and for military personnel, SIR = 1.09, 95% CI: 1.05-1.13; pheterogeneity = 0.005 and 0.002, respectively). Administrators and technical workers also demonstrated significantly increased risks for early-onset prostate cancer, but the SIRs did not differ from those of later-onset disease (pheterogeneity >0.05). While our early-onset finding for public safety workers was restricted to the post-PSA period, that for military personnel was restricted to the pre-PSA period.CONCLUSION: Our results suggest that occupational exposures, particularly for military personnel, may be associated with early-onset prostate cancer. Further evaluation is needed to explain these findings.",

keywords = "Journal Article",

author = "{Hughes Barry}, Kathryn and Martinsen, {Jan Ivar} and Alavanja, {Michael C. R.} and Gabriella Andreotti and Aaron Blair and Johnni Hansen and Kristina Kj{\ae}rheim and Stella Koutros and Elsebeth Lynge and P{\"a}r Spar{\`e}n and Laufey Tryggvadottir and Elisabete Weiderpass and Berndt, {Sonja I.} and Eero Pukkala",

year = "2017",

month = dec,

doi = "10.1016/j.ejca.2017.09.023",

language = "English",

volume = "87",

pages = "92--100",

journal = "European Journal of Cancer, Supplement",

issn = "0959-8049",

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T1 - Risk of early-onset prostate cancer associated with occupation in the Nordic countries

AU - Hughes Barry, Kathryn

AU - Martinsen, Jan Ivar

AU - Alavanja, Michael C. R.

AU - Andreotti, Gabriella

AU - Blair, Aaron

AU - Hansen, Johnni

AU - Kjærheim, Kristina

AU - Koutros, Stella

AU - Lynge, Elsebeth

AU - Sparèn, Pär

AU - Tryggvadottir, Laufey

AU - Weiderpass, Elisabete

AU - Berndt, Sonja I.

AU - Pukkala, Eero

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND: Early-onset prostate cancer is often more aggressive and may have a different aetiology than later-onset prostate cancer, but has been relatively little studied to date. We evaluated occupation in relation to early- and later-onset prostate cancer in a large pooled study.METHODS: We used occupational information from census data in five Nordic countries from 1960 to 1990. We identified prostate cancer cases diagnosed from 1961 to 2005 by linkage of census information to national cancer registries and calculated standardised incidence ratios (SIRs) separately for men aged 30-49 and those aged 50 or older. We also conducted separate analyses by period of follow-up, 1961-1985 and 1986-2005, corresponding to pre- and post-prostate-specific antigen (PSA) screening.RESULTS: For early-onset prostate cancer (n = 1521), we observed the highest SIRs for public safety workers (e.g. firefighters) (SIR = 1.71, 95% confidence interval [CI]: 1.23-2.31) and military personnel (SIR = 1.97, 95% CI: 1.31-2.85). These SIRs were significantly higher than the SIRs for later-onset disease (for public safety workers, SIR = 1.10, 95% CI: 1.07-1.14 and for military personnel, SIR = 1.09, 95% CI: 1.05-1.13; pheterogeneity = 0.005 and 0.002, respectively). Administrators and technical workers also demonstrated significantly increased risks for early-onset prostate cancer, but the SIRs did not differ from those of later-onset disease (pheterogeneity >0.05). While our early-onset finding for public safety workers was restricted to the post-PSA period, that for military personnel was restricted to the pre-PSA period.CONCLUSION: Our results suggest that occupational exposures, particularly for military personnel, may be associated with early-onset prostate cancer. Further evaluation is needed to explain these findings.

AB - BACKGROUND: Early-onset prostate cancer is often more aggressive and may have a different aetiology than later-onset prostate cancer, but has been relatively little studied to date. We evaluated occupation in relation to early- and later-onset prostate cancer in a large pooled study.METHODS: We used occupational information from census data in five Nordic countries from 1960 to 1990. We identified prostate cancer cases diagnosed from 1961 to 2005 by linkage of census information to national cancer registries and calculated standardised incidence ratios (SIRs) separately for men aged 30-49 and those aged 50 or older. We also conducted separate analyses by period of follow-up, 1961-1985 and 1986-2005, corresponding to pre- and post-prostate-specific antigen (PSA) screening.RESULTS: For early-onset prostate cancer (n = 1521), we observed the highest SIRs for public safety workers (e.g. firefighters) (SIR = 1.71, 95% confidence interval [CI]: 1.23-2.31) and military personnel (SIR = 1.97, 95% CI: 1.31-2.85). These SIRs were significantly higher than the SIRs for later-onset disease (for public safety workers, SIR = 1.10, 95% CI: 1.07-1.14 and for military personnel, SIR = 1.09, 95% CI: 1.05-1.13; pheterogeneity = 0.005 and 0.002, respectively). Administrators and technical workers also demonstrated significantly increased risks for early-onset prostate cancer, but the SIRs did not differ from those of later-onset disease (pheterogeneity >0.05). While our early-onset finding for public safety workers was restricted to the post-PSA period, that for military personnel was restricted to the pre-PSA period.CONCLUSION: Our results suggest that occupational exposures, particularly for military personnel, may be associated with early-onset prostate cancer. Further evaluation is needed to explain these findings.

KW - Journal Article

U2 - 10.1016/j.ejca.2017.09.023

DO - 10.1016/j.ejca.2017.09.023

M3 - Journal article

C2 - 29132062

SN - 0959-8049

VL - 87

SP - 92

EP - 100

JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

ER -

Risk of early-onset prostate cancer associated with occupation in the Nordic countries

Abstract

Keywords

UN SDGs

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