Risk of bladder cancer in patients with diabetes: a retrospective cohort study

Maria E Goossens; Maurice P Zeegers; Marloes T Bazelier; Marie L De Bruin; Frank Buntinx; Frank de Vries

doi:10.1136/bmjopen-2014-007470

Risk of bladder cancer in patients with diabetes: a retrospective cohort study

Maria E Goossens, Maurice P Zeegers, Marloes T Bazelier, Marie L De Bruin, Frank Buntinx, Frank de Vries

12 Citations (Scopus)

Abstract

OBJECTIVE: The objective of this study was to examine the association between diabetes, and both urinary bladder cancer (UBC) risk and mortality.

METHODS: We conducted a retrospective cohort study using data from the UK Clinical Practice Research Datalink (CPRD) linked to the Office of National Statistics (ONS). Patients diagnosed with diabetes mellitus type 1 or 2, or using antidiabetic drugs (ADDs), were compared to matched non-diabetic controls. Cox proportional hazards models were used to estimate the risk and mortality of UBC. We adjusted for age, sex, smoking status and body mass index.

RESULTS: The cohort included 329,168 patients using ADD, and 307,315 controls with 1295 and 1071 patients, respectively, diagnosed as having UBC during follow-up. The adjusted HRs of UBC were 0.77 (95% CI 0.57 to 1.05) and 1.04 (95% CI 0.96 to 1.14) for type 1 and 2 diabetes, respectively. These results were similar if we restricted our analysis to an inception cohort. We noticed a small increased risk during the first year after diagnosis (HR=1.26 (95% CI 1.05 to 1.52)), which could be explained by detection bias. There was no influence of the severity of diabetes as measured by the glycated haemoglobin. Mortality of UBC was not increased for patients with either type 1 (HR=0.95 (95% CI 0.39 to 2.34)) or type 2 diabetes (HR=1.16 (95% CI 0.91 to 1.46)).

CONCLUSIONS: Neither the risk of UBC nor the mortality from UBC was increased in patients with type 1 and patients with type 2 diabetes in the CPRD data.

Original language	English
Journal	B M J Open
Volume	5
Issue number	6
Pages (from-to)	e007470
ISSN	2044-6055
DOIs	https://doi.org/10.1136/bmjopen-2014-007470
Publication status	Published - 2015
Externally published	Yes

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Female
Great Britain
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Risk Factors
Urinary Bladder Neoplasms
Young Adult
Journal Article
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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e007470.full.pdfFinal published version, 666 KBLicence: CC BY-NC-ND

Cite this

@article{a099e5bf939445cd8cd62b6021ff054a,

title = "Risk of bladder cancer in patients with diabetes: a retrospective cohort study",

abstract = "OBJECTIVE: The objective of this study was to examine the association between diabetes, and both urinary bladder cancer (UBC) risk and mortality.METHODS: We conducted a retrospective cohort study using data from the UK Clinical Practice Research Datalink (CPRD) linked to the Office of National Statistics (ONS). Patients diagnosed with diabetes mellitus type 1 or 2, or using antidiabetic drugs (ADDs), were compared to matched non-diabetic controls. Cox proportional hazards models were used to estimate the risk and mortality of UBC. We adjusted for age, sex, smoking status and body mass index.RESULTS: The cohort included 329,168 patients using ADD, and 307,315 controls with 1295 and 1071 patients, respectively, diagnosed as having UBC during follow-up. The adjusted HRs of UBC were 0.77 (95% CI 0.57 to 1.05) and 1.04 (95% CI 0.96 to 1.14) for type 1 and 2 diabetes, respectively. These results were similar if we restricted our analysis to an inception cohort. We noticed a small increased risk during the first year after diagnosis (HR=1.26 (95% CI 1.05 to 1.52)), which could be explained by detection bias. There was no influence of the severity of diabetes as measured by the glycated haemoglobin. Mortality of UBC was not increased for patients with either type 1 (HR=0.95 (95% CI 0.39 to 2.34)) or type 2 diabetes (HR=1.16 (95% CI 0.91 to 1.46)).CONCLUSIONS: Neither the risk of UBC nor the mortality from UBC was increased in patients with type 1 and patients with type 2 diabetes in the CPRD data.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Female, Great Britain, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Urinary Bladder Neoplasms, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",

author = "Goossens, {Maria E} and Zeegers, {Maurice P} and Bazelier, {Marloes T} and {De Bruin}, {Marie L} and Frank Buntinx and {de Vries}, Frank",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2015",

doi = "10.1136/bmjopen-2014-007470",

language = "English",

volume = "5",

pages = "e007470",

journal = "BMJ Open",

issn = "2044-6055",

publisher = "BMJ Publishing Group",

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TY - JOUR

T1 - Risk of bladder cancer in patients with diabetes

T2 - a retrospective cohort study

AU - Goossens, Maria E

AU - Zeegers, Maurice P

AU - Bazelier, Marloes T

AU - De Bruin, Marie L

AU - Buntinx, Frank

AU - de Vries, Frank

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: The objective of this study was to examine the association between diabetes, and both urinary bladder cancer (UBC) risk and mortality.METHODS: We conducted a retrospective cohort study using data from the UK Clinical Practice Research Datalink (CPRD) linked to the Office of National Statistics (ONS). Patients diagnosed with diabetes mellitus type 1 or 2, or using antidiabetic drugs (ADDs), were compared to matched non-diabetic controls. Cox proportional hazards models were used to estimate the risk and mortality of UBC. We adjusted for age, sex, smoking status and body mass index.RESULTS: The cohort included 329,168 patients using ADD, and 307,315 controls with 1295 and 1071 patients, respectively, diagnosed as having UBC during follow-up. The adjusted HRs of UBC were 0.77 (95% CI 0.57 to 1.05) and 1.04 (95% CI 0.96 to 1.14) for type 1 and 2 diabetes, respectively. These results were similar if we restricted our analysis to an inception cohort. We noticed a small increased risk during the first year after diagnosis (HR=1.26 (95% CI 1.05 to 1.52)), which could be explained by detection bias. There was no influence of the severity of diabetes as measured by the glycated haemoglobin. Mortality of UBC was not increased for patients with either type 1 (HR=0.95 (95% CI 0.39 to 2.34)) or type 2 diabetes (HR=1.16 (95% CI 0.91 to 1.46)).CONCLUSIONS: Neither the risk of UBC nor the mortality from UBC was increased in patients with type 1 and patients with type 2 diabetes in the CPRD data.

AB - OBJECTIVE: The objective of this study was to examine the association between diabetes, and both urinary bladder cancer (UBC) risk and mortality.METHODS: We conducted a retrospective cohort study using data from the UK Clinical Practice Research Datalink (CPRD) linked to the Office of National Statistics (ONS). Patients diagnosed with diabetes mellitus type 1 or 2, or using antidiabetic drugs (ADDs), were compared to matched non-diabetic controls. Cox proportional hazards models were used to estimate the risk and mortality of UBC. We adjusted for age, sex, smoking status and body mass index.RESULTS: The cohort included 329,168 patients using ADD, and 307,315 controls with 1295 and 1071 patients, respectively, diagnosed as having UBC during follow-up. The adjusted HRs of UBC were 0.77 (95% CI 0.57 to 1.05) and 1.04 (95% CI 0.96 to 1.14) for type 1 and 2 diabetes, respectively. These results were similar if we restricted our analysis to an inception cohort. We noticed a small increased risk during the first year after diagnosis (HR=1.26 (95% CI 1.05 to 1.52)), which could be explained by detection bias. There was no influence of the severity of diabetes as measured by the glycated haemoglobin. Mortality of UBC was not increased for patients with either type 1 (HR=0.95 (95% CI 0.39 to 2.34)) or type 2 diabetes (HR=1.16 (95% CI 0.91 to 1.46)).CONCLUSIONS: Neither the risk of UBC nor the mortality from UBC was increased in patients with type 1 and patients with type 2 diabetes in the CPRD data.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Diabetes Mellitus, Type 1

KW - Diabetes Mellitus, Type 2

KW - Female

KW - Great Britain

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Retrospective Studies

KW - Risk Factors

KW - Urinary Bladder Neoplasms

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1136/bmjopen-2014-007470

DO - 10.1136/bmjopen-2014-007470

M3 - Journal article

C2 - 26033947

SN - 2044-6055

VL - 5

SP - e007470

JO - BMJ Open

JF - BMJ Open

IS - 6

ER -

Risk of bladder cancer in patients with diabetes: a retrospective cohort study

Abstract

Keywords

UN SDGs

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