Risk for tuberculosis among children

Hiroshi Nakaoka; Lovett Lawson; S Bertel Squire; Brian Coulter; Pernille Ravn; Inger Brock; C Anthony Hart; Luis E Cuevas

Risk for tuberculosis among children

Hiroshi Nakaoka, Lovett Lawson, S Bertel Squire, Brian Coulter, Pernille Ravn, Inger Brock, C Anthony Hart, Luis E Cuevas

114 Citations (Scopus)

Abstract

Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-gamma (IFN-gamma) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-y-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p < 0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.

Original language	English
Journal	Emerging Infectious Diseases (Print Edition)
Volume	12
Issue number	9
Pages (from-to)	1383-8
Number of pages	5
ISSN	1080-6040
Publication status	Published - 2006

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@article{e07a383b468540e0a51099cf8db86986,

title = "Risk for tuberculosis among children",

abstract = "Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-gamma (IFN-gamma) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-y-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p < 0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.",

author = "Hiroshi Nakaoka and Lovett Lawson and Squire, {S Bertel} and Brian Coulter and Pernille Ravn and Inger Brock and Hart, {C Anthony} and Cuevas, {Luis E}",

year = "2006",

language = "English",

volume = "12",

pages = "1383--8",

journal = "Emerging Infectious Diseases (Print Edition)",

issn = "1080-6040",

publisher = "CDC Centers for Disease Control and Prevention",

number = "9",

}

TY - JOUR

T1 - Risk for tuberculosis among children

AU - Nakaoka, Hiroshi

AU - Lawson, Lovett

AU - Squire, S Bertel

AU - Coulter, Brian

AU - Ravn, Pernille

AU - Brock, Inger

AU - Hart, C Anthony

AU - Cuevas, Luis E

PY - 2006

Y1 - 2006

N2 - Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-gamma (IFN-gamma) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-y-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p < 0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.

AB - Contacts of adults with tuberculosis (TB) are at risk for infection. Tests based on interferon-gamma (IFN-gamma) expression in response to Mycobacterium tuberculosis antigens may be more sensitive than the tuberculin skin test (TST). Risk for infection was assessed by using TST and an IFN-y-based assay (QuantiFERON Gold in Tube [QFT-IT] test) for 207 children in Nigeria in 1 of 3 groups: contact with adults with smear-positive TB, contact with adults with smear-negative TB, and controls. For these 3 groups, respectively, TST results were >10 mm for 38 (49%) of 78, 13 (16%) of 83, and 6 (13%) of 46 and QFT-IT positive for 53 (74%) of 72, 8 (10%) of 81, and 4 (10.3%) of 39 (p < 0.01). Most test discrepancies were TST negative; QFT-IT positive if in contact with TB-positive persons; and TST positive, QFT-IT negative if in contact with TB-negative persons or controls. TST may underestimate risk for infection with TB in children.

M3 - Journal article

SN - 1080-6040

VL - 12

SP - 1383

EP - 1388

JO - Emerging Infectious Diseases (Print Edition)

JF - Emerging Infectious Diseases (Print Edition)

IS - 9

ER -

Risk for tuberculosis among children

Abstract

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