Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study.

Wolfgang Ahrens; Antje Timmer; Mogens Vyberg; Tony Fletcher; Pascal Guénel; Enzo Merler; Franco Merletti; Maria Morales; Håkan Olsson; Jorn Olsen; Lennart Hardell; Linda Kaerlev; Nicole Raverdy; Elsebeth Lynge

doi:10.1097/01.meg.0000243876.79325.a1

Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study.

Wolfgang Ahrens, Antje Timmer, Mogens Vyberg, Tony Fletcher, Pascal Guénel, Enzo Merler, Franco Merletti, Maria Morales, Håkan Olsson, Jorn Olsen, Lennart Hardell, Linda Kaerlev, Nicole Raverdy, Elsebeth Lynge

Center of Epidemiology and Screening

40 Citations (Scopus)

Abstract

OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable.

Original language	English
Journal	European Journal of Gastroenterology and Hepathology
Volume	19
Issue number	8
Pages (from-to)	623-30
Number of pages	7
ISSN	0954-691X
DOIs	https://doi.org/10.1097/01.meg.0000243876.79325.a1
Publication status	Published - 2007

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Ahrens, W., Timmer, A., Vyberg, M., Fletcher, T., Guénel, P., Merler, E., Merletti, F., Morales, M., Olsson, H., Olsen, J., Hardell, L., Kaerlev, L., Raverdy, N., & Lynge, E. (2007). Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study. European Journal of Gastroenterology and Hepathology, 19(8), 623-30. https://doi.org/10.1097/01.meg.0000243876.79325.a1

Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study. / Ahrens, Wolfgang; Timmer, Antje; Vyberg, Mogens et al.

In: European Journal of Gastroenterology and Hepathology, Vol. 19, No. 8, 2007, p. 623-30.

Research output: Contribution to journal › Journal article › Research › peer-review

Ahrens, W, Timmer, A, Vyberg, M, Fletcher, T, Guénel, P, Merler, E, Merletti, F, Morales, M, Olsson, H, Olsen, J, Hardell, L, Kaerlev, L, Raverdy, N & Lynge, E 2007, 'Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study.', European Journal of Gastroenterology and Hepathology, vol. 19, no. 8, pp. 623-30. https://doi.org/10.1097/01.meg.0000243876.79325.a1

@article{e3aafcd0b24e11ddb04f000ea68e967b,

title = "Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study.",

abstract = "OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable.",

author = "Wolfgang Ahrens and Antje Timmer and Mogens Vyberg and Tony Fletcher and Pascal Gu{\'e}nel and Enzo Merler and Franco Merletti and Maria Morales and H{\aa}kan Olsson and Jorn Olsen and Lennart Hardell and Linda Kaerlev and Nicole Raverdy and Elsebeth Lynge",

note = "Keywords: Adult; Aged; Ampulla of Vater; Bile Ducts, Extrahepatic; Biliary Tract Neoplasms; Body Mass Index; Case-Control Studies; Cholelithiasis; Common Bile Duct Neoplasms; Gallbladder Neoplasms; Humans; Life Style; Male; Middle Aged; Obesity; Risk Factors",

year = "2007",

doi = "10.1097/01.meg.0000243876.79325.a1",

language = "English",

volume = "19",

pages = "623--30",

journal = "European Journal of Gastroenterology and Hepatology, Supplement",

issn = "0954-691X",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "8",

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TY - JOUR

T1 - Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study.

AU - Ahrens, Wolfgang

AU - Timmer, Antje

AU - Vyberg, Mogens

AU - Fletcher, Tony

AU - Guénel, Pascal

AU - Merler, Enzo

AU - Merletti, Franco

AU - Morales, Maria

AU - Olsson, Håkan

AU - Olsen, Jorn

AU - Hardell, Lennart

AU - Kaerlev, Linda

AU - Raverdy, Nicole

AU - Lynge, Elsebeth

N1 - Keywords: Adult; Aged; Ampulla of Vater; Bile Ducts, Extrahepatic; Biliary Tract Neoplasms; Body Mass Index; Case-Control Studies; Cholelithiasis; Common Bile Duct Neoplasms; Gallbladder Neoplasms; Humans; Life Style; Male; Middle Aged; Obesity; Risk Factors

PY - 2007

Y1 - 2007

N2 - OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable.

AB - OBJECTIVES: To identify risk factors of carcinoma of the extrahepatic biliary tract in men. METHODS: Newly diagnosed and histologically confirmed patients, 35-70 years old, were interviewed between 1995 and 1997 in Denmark, Sweden, France, Germany and Italy. Population controls were frequency-matched by age and region. Adjusted odds ratios and 95%-confidence intervals were estimated by logistic regression. RESULTS: The analysis included 153 patients and 1421 controls. The participation proportion was 71% for patients and 61% for controls. Gallstone disease was corroborated as a risk factor for extrahepatic biliary tract carcinoma in men (odds ratio 2.49; 95% confidence interval 1.32-4.70), particularly for gall bladder tumors (odds ratio 4.68; 95% confidence interval 1.85-11.84). For a body mass index [height (m) divided by squared weight (kg2)] >30 at age 35 years, an excess risk was observed (odds ratio 2.58; 95% confidence interval 1.07-6.23, reference: body mass index 18.5-25) that was even stronger if the body mass index was >30 for the lowest weight in adulthood (odds ratio 4.68; 95% confidence interval 1.13-19.40). Infection of the gall bladder, chronic inflammatory bowel disease, hepatitis or smoking showed no clear association, whereas some increase in risk was suggested for consumption of 40-80 g alcohol per day and more. CONCLUSIONS: Our study corroborates gallstones as a risk indicator in extrahepatic biliary tract carcinoma. Permanent overweight and obesity in adult life was identified as a strong risk factor for extrahepatic biliary tract carcinoma, whereas we did not find any strong lifestyle-associated risk factors. Inconsistent results across studies concerning the association of extrahepatic biliary tract carcinoma with overweight and obesity may be explained by the different approaches to assess this variable.

U2 - 10.1097/01.meg.0000243876.79325.a1

DO - 10.1097/01.meg.0000243876.79325.a1

M3 - Journal article

C2 - 17625430

SN - 0954-691X

VL - 19

SP - 623

EP - 630

JO - European Journal of Gastroenterology and Hepatology, Supplement

JF - European Journal of Gastroenterology and Hepatology, Supplement

IS - 8

ER -

Risk factors for extrahepatic biliary tract carcinoma in men: medical conditions and lifestyle: results from a European multicentre case-control study.

Abstract

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