Risk assessment of clinical reactions to legumes in peanut-allergic children

Louise Bjerremann Jensen; Milene Andersen; Per Stahl Skov; Lars K. Poulsen; Carsten Bindslev-Jensen

doi:10.1097/WOX.0b013e3181865f83

Risk assessment of clinical reactions to legumes in peanut-allergic children

Louise Bjerremann Jensen, Milene Andersen, Per Stahl Skov, Lars K. Poulsen, Carsten Bindslev-Jensen

Abstract

Peanut-allergic children might be at risk for reactions to other legumes. However, it is not always possible to perform multiple oral food challenges in children. On the basis of patient case history, in vitro diagnostic tests, and eventually food challenges, we aimed at developing an algorithm for risk assessment of possible clinical reactions to other legumes (soybean, lupine, fresh, and blanched green pea). Seventy-five consecutive patients with a positive oral food challenge to peanut were included in the study. All tests were run as part of the routine allergy examination. A high proportion of patients and/or caretakers refused the administered legume oral food challenges. Obtained diagnoses from histamine release did not correlate significantly to the outcome of the algorithm. Interestingly, threshold from peanut challenges did not correlate with the risk assessment.The algorithm presented in this study can be used when advising peanut-allergic children and their caretakers about what other legumes to avoid in the diet.

Original language	English
Journal	World Allergy Organization Journal
Volume	1
Issue number	10
Pages (from-to)	162-167
Number of pages	6
ISSN	1939-4551
DOIs	https://doi.org/10.1097/WOX.0b013e3181865f83
Publication status	Published - 2008

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title = "Risk assessment of clinical reactions to legumes in peanut-allergic children",

abstract = "Peanut-allergic children might be at risk for reactions to other legumes. However, it is not always possible to perform multiple oral food challenges in children. On the basis of patient case history, in vitro diagnostic tests, and eventually food challenges, we aimed at developing an algorithm for risk assessment of possible clinical reactions to other legumes (soybean, lupine, fresh, and blanched green pea). Seventy-five consecutive patients with a positive oral food challenge to peanut were included in the study. All tests were run as part of the routine allergy examination. A high proportion of patients and/or caretakers refused the administered legume oral food challenges. Obtained diagnoses from histamine release did not correlate significantly to the outcome of the algorithm. Interestingly, threshold from peanut challenges did not correlate with the risk assessment.The algorithm presented in this study can be used when advising peanut-allergic children and their caretakers about what other legumes to avoid in the diet.",

author = "Jensen, {Louise Bjerremann} and Milene Andersen and Skov, {Per Stahl} and Poulsen, {Lars K.} and Carsten Bindslev-Jensen",

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AU - Jensen, Louise Bjerremann

AU - Andersen, Milene

AU - Skov, Per Stahl

AU - Poulsen, Lars K.

AU - Bindslev-Jensen, Carsten

PY - 2008

Y1 - 2008

N2 - Peanut-allergic children might be at risk for reactions to other legumes. However, it is not always possible to perform multiple oral food challenges in children. On the basis of patient case history, in vitro diagnostic tests, and eventually food challenges, we aimed at developing an algorithm for risk assessment of possible clinical reactions to other legumes (soybean, lupine, fresh, and blanched green pea). Seventy-five consecutive patients with a positive oral food challenge to peanut were included in the study. All tests were run as part of the routine allergy examination. A high proportion of patients and/or caretakers refused the administered legume oral food challenges. Obtained diagnoses from histamine release did not correlate significantly to the outcome of the algorithm. Interestingly, threshold from peanut challenges did not correlate with the risk assessment.The algorithm presented in this study can be used when advising peanut-allergic children and their caretakers about what other legumes to avoid in the diet.

AB - Peanut-allergic children might be at risk for reactions to other legumes. However, it is not always possible to perform multiple oral food challenges in children. On the basis of patient case history, in vitro diagnostic tests, and eventually food challenges, we aimed at developing an algorithm for risk assessment of possible clinical reactions to other legumes (soybean, lupine, fresh, and blanched green pea). Seventy-five consecutive patients with a positive oral food challenge to peanut were included in the study. All tests were run as part of the routine allergy examination. A high proportion of patients and/or caretakers refused the administered legume oral food challenges. Obtained diagnoses from histamine release did not correlate significantly to the outcome of the algorithm. Interestingly, threshold from peanut challenges did not correlate with the risk assessment.The algorithm presented in this study can be used when advising peanut-allergic children and their caretakers about what other legumes to avoid in the diet.

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Risk assessment of clinical reactions to legumes in peanut-allergic children

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