Rho GTPase function in tumorigenesis

R Karlsson; Esben Ditlev Kølle Pedersen; Zhipeng Wang; Cord Brakebusch

doi:10.1016/j.bbcan.2009.03.003

Rho GTPase function in tumorigenesis

R Karlsson, Esben Ditlev Kølle Pedersen, Zhipeng Wang, Cord Brakebusch

264 Citations (Scopus)

Abstract

Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.

Original language	English
Journal	BBA General Subjects
ISSN	0304-4165
DOIs	https://doi.org/10.1016/j.bbcan.2009.03.003
Publication status	Published - 2009

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10.1016/j.bbcan.2009.03.003

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title = "Rho GTPase function in tumorigenesis",

abstract = "Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.",

author = "R Karlsson and Pedersen, {Esben Ditlev K{\o}lle} and Zhipeng Wang and Cord Brakebusch",

year = "2009",

doi = "10.1016/j.bbcan.2009.03.003",

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T1 - Rho GTPase function in tumorigenesis

AU - Karlsson, R

AU - Pedersen, Esben Ditlev Kølle

AU - Wang, Zhipeng

AU - Brakebusch, Cord

PY - 2009

Y1 - 2009

N2 - Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.

AB - Malignant tumor cells display uncontrolled proliferation, loss of epithelial cell polarity, altered interactions with neighboring cells and the surrounding extracellular matrix, and enhanced migratory properties. Proteins of the Rho GTPase family regulate all these processes in cell culture and, for that reason, Rho GTPases, their regulators, and their effectors have been suggested to control tumor formation and progression in humans. However, while the tumor-relevant functions of Rho GTPases are very well documented in vitro, we are only now beginning to assess their contribution to cancer in human patients and in animal models. This review will give a very brief overview of Rho GTPase function in general and then focus on in vivo evidence for a role of Rho GTPases in malignant tumors, both in human patients and in genetically modified mice.

U2 - 10.1016/j.bbcan.2009.03.003

DO - 10.1016/j.bbcan.2009.03.003

M3 - Journal article

C2 - 19327386

SN - 0304-4165

JO - B B A - General Subjects

JF - B B A - General Subjects

ER -

Rho GTPase function in tumorigenesis

Abstract

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