TY - JOUR
T1 - Rho GTPase function in development
T2 - How in vivo models change our view
AU - Pedersen, Esben
AU - Brakebusch, Cord
N1 - Copyright © 2012 Elsevier Inc. All rights reserved.
PY - 2012/8/15
Y1 - 2012/8/15
N2 - Rho GTPase functions have been carefully investigated for many years using cell biological models. In recent years, mouse models with targeted mutations in Rho GTPase genes enabled the study of Rho GTPase function in vivo, partially confirming and partially contradicting expectations based on earlier in vitro experiments. This review sums up recent findings on the role of Rho GTPases in development, underlining the importance of in vivo research for our understanding of Rho GTPases in living organisms, and describing challenges for the future.
AB - Rho GTPase functions have been carefully investigated for many years using cell biological models. In recent years, mouse models with targeted mutations in Rho GTPase genes enabled the study of Rho GTPase function in vivo, partially confirming and partially contradicting expectations based on earlier in vitro experiments. This review sums up recent findings on the role of Rho GTPases in development, underlining the importance of in vivo research for our understanding of Rho GTPases in living organisms, and describing challenges for the future.
U2 - 10.1016/j.yexcr.2012.05.004
DO - 10.1016/j.yexcr.2012.05.004
M3 - Journal article
C2 - 22659168
SN - 0014-4827
VL - 318
SP - 1779
EP - 1787
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 14
ER -