Revised hypothesis and future perspectives

P Norsk; C Drummer; N J Christensen; M Cirillo; M Heer; H J Kramer; J Regnard; N G De Santo

doi:10.1053/ajkd.2001.27769

Revised hypothesis and future perspectives

P Norsk, C Drummer, N J Christensen, M Cirillo, M Heer, H J Kramer, J Regnard, N G De Santo

Renal and Vascular Research

14 Citations (Scopus)

Abstract

Results from space have been unexpected and not predictable from the results of ground-based simulations. Therefore, the concept of how weightlessness and gravity modulates the regulation of body fluids must be revised and a new simulation model developed. The main questions to ask in the future are the following: Does weightlessness induce a diuresis and natriuresis during the initial hours of space flight leading to an extracellular and intravascular fluid volume deficit? Can sodium in excess be stored in a hitherto unknown way, particularly during space flight? Why are fluid and sodium retaining systems activated by spaceflight? Why are the renal responses to saline and water stimuli in space attenuated compared with those of ground simulations? How can the effects of weightlessness on fluid and electrolyte regulation be correctly simulated on the ground? The information obtained from space may be of relevance to fluid and electrolyte balance in edematous patients.

Original language	English
Journal	American Journal of Kidney Diseases
Volume	38
Issue number	3
Pages (from-to)	696-8
Number of pages	3
ISSN	0272-6386
DOIs	https://doi.org/10.1053/ajkd.2001.27769
Publication status	Published - 1 Sept 2001

Keywords

Blood Volume
Diuresis
Drinking
Eating
Forecasting
Heart Failure
Humans
Kidney
Models, Biological
Natriuresis
Space Flight

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10.1053/ajkd.2001.27769

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title = "Revised hypothesis and future perspectives",

abstract = "Results from space have been unexpected and not predictable from the results of ground-based simulations. Therefore, the concept of how weightlessness and gravity modulates the regulation of body fluids must be revised and a new simulation model developed. The main questions to ask in the future are the following: Does weightlessness induce a diuresis and natriuresis during the initial hours of space flight leading to an extracellular and intravascular fluid volume deficit? Can sodium in excess be stored in a hitherto unknown way, particularly during space flight? Why are fluid and sodium retaining systems activated by spaceflight? Why are the renal responses to saline and water stimuli in space attenuated compared with those of ground simulations? How can the effects of weightlessness on fluid and electrolyte regulation be correctly simulated on the ground? The information obtained from space may be of relevance to fluid and electrolyte balance in edematous patients.",

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author = "P Norsk and C Drummer and Christensen, {N J} and M Cirillo and M Heer and Kramer, {H J} and J Regnard and {De Santo}, {N G}",

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T1 - Revised hypothesis and future perspectives

AU - Norsk, P

AU - Drummer, C

AU - Christensen, N J

AU - Cirillo, M

AU - Heer, M

AU - Kramer, H J

AU - Regnard, J

AU - De Santo, N G

PY - 2001/9/1

Y1 - 2001/9/1

N2 - Results from space have been unexpected and not predictable from the results of ground-based simulations. Therefore, the concept of how weightlessness and gravity modulates the regulation of body fluids must be revised and a new simulation model developed. The main questions to ask in the future are the following: Does weightlessness induce a diuresis and natriuresis during the initial hours of space flight leading to an extracellular and intravascular fluid volume deficit? Can sodium in excess be stored in a hitherto unknown way, particularly during space flight? Why are fluid and sodium retaining systems activated by spaceflight? Why are the renal responses to saline and water stimuli in space attenuated compared with those of ground simulations? How can the effects of weightlessness on fluid and electrolyte regulation be correctly simulated on the ground? The information obtained from space may be of relevance to fluid and electrolyte balance in edematous patients.

AB - Results from space have been unexpected and not predictable from the results of ground-based simulations. Therefore, the concept of how weightlessness and gravity modulates the regulation of body fluids must be revised and a new simulation model developed. The main questions to ask in the future are the following: Does weightlessness induce a diuresis and natriuresis during the initial hours of space flight leading to an extracellular and intravascular fluid volume deficit? Can sodium in excess be stored in a hitherto unknown way, particularly during space flight? Why are fluid and sodium retaining systems activated by spaceflight? Why are the renal responses to saline and water stimuli in space attenuated compared with those of ground simulations? How can the effects of weightlessness on fluid and electrolyte regulation be correctly simulated on the ground? The information obtained from space may be of relevance to fluid and electrolyte balance in edematous patients.

KW - Blood Volume

KW - Diuresis

KW - Drinking

KW - Eating

KW - Forecasting

KW - Heart Failure

KW - Humans

KW - Kidney

KW - Models, Biological

KW - Natriuresis

KW - Space Flight

U2 - 10.1053/ajkd.2001.27769

DO - 10.1053/ajkd.2001.27769

M3 - Journal article

C2 - 11532709

SN - 0272-6386

VL - 38

SP - 696

EP - 698

JO - American Journal of Kidney Diseases

JF - American Journal of Kidney Diseases

IS - 3

ER -

Revised hypothesis and future perspectives

Abstract

Keywords

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