Abstract
Regional perfusion and vascular resistance were examined in different tissues with the radioactive microsphere technique in Göttingen minipigs before, during and after treatment with Intralipid and heparin. This treatment led to an increase in the free fatty acid/albumin molar ratio from 0.39 +/- 0.23 to 3.43 +/- 1.37. Concomitantly a decrease in regional perfusion and an increase in regional vascular resistance was found in skin, adipose tissue, skeletal muscle, kidney, the gastro-intestinal tract, the thyroid and pancreas, while heart and liver showed vasodilatation. The vascular effects were fully reversible when the free fatty acid/albumin molar ratio had normalized. This vascular effect of lipid emulsions has to be considered when patients are treated with parenteral nutrition.
| Original language | English |
|---|---|
| Book series | Scandinavian Journal of Clinical and Laboratory Investigation. Supplement |
| Volume | 50 |
| Issue number | 3 |
| Pages (from-to) | 291-6 |
| Number of pages | 6 |
| ISSN | 0036-5513 |
| Publication status | Published - May 1990 |
Keywords
- Adipose Tissue
- Animals
- Bone and Bones
- Coronary Circulation
- Digestive System
- Fat Emulsions, Intravenous
- Fatty Acids, Nonesterified
- Female
- Heparin
- Kidney
- Lipids
- Liver
- Muscles
- Pancreas
- Serum Albumin
- Skin
- Swine
- Swine, Miniature
- Thyroid Gland
- Vascular Resistance
- Journal Article
- Research Support, Non-U.S. Gov't