Retrograde signaling: organelles go networking

TY - JOUR

T1 - Retrograde signaling

T2 - European Bioenergetics Conference 2016

AU - Kleine, Tatjana

AU - Leister, Dario Michael

N1 - Conference code: 19

PY - 2016/8/1

Y1 - 2016/8/1

N2 - The term retrograde signaling refers to the fact that chloroplasts and mitochondria utilize specific signaling molecules to convey information on their developmental and physiological states to the nucleus and modulate the expression of nuclear genes accordingly. Signals emanating from plastids have been associated with two main networks: 'Biogenic control' is active during early stages of chloroplast development, while 'operational' control functions in response to environmental fluctuations. Early work focused on the former and its major players, the GUN proteins. However, our view of retrograde signaling has since been extended and revised. Elements of several 'operational' signaling circuits have come to light, including metabolites, signaling cascades in the cytosol and transcription factors. Here, we review recent advances in the identification and characterization of retrograde signaling components. We place particular emphasis on the strategies employed to define signaling components, spanning the entire spectrum of genetic screens, metabolite profiling and bioinformatics. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.

AB - The term retrograde signaling refers to the fact that chloroplasts and mitochondria utilize specific signaling molecules to convey information on their developmental and physiological states to the nucleus and modulate the expression of nuclear genes accordingly. Signals emanating from plastids have been associated with two main networks: 'Biogenic control' is active during early stages of chloroplast development, while 'operational' control functions in response to environmental fluctuations. Early work focused on the former and its major players, the GUN proteins. However, our view of retrograde signaling has since been extended and revised. Elements of several 'operational' signaling circuits have come to light, including metabolites, signaling cascades in the cytosol and transcription factors. Here, we review recent advances in the identification and characterization of retrograde signaling components. We place particular emphasis on the strategies employed to define signaling components, spanning the entire spectrum of genetic screens, metabolite profiling and bioinformatics. This article is part of a Special Issue entitled 'EBEC 2016: 19th European Bioenergetics Conference, Riva del Garda, Italy, July 2-6, 2016', edited by Prof. Paolo Bernardi.

KW - Arabidopsis

KW - Arabidopsis Proteins

KW - Cell Nucleus

KW - Chloroplasts

KW - Computational Biology

KW - DNA-Binding Proteins

KW - Feedback, Physiological

KW - Gene Expression Regulation, Developmental

KW - Gene Expression Regulation, Plant

KW - Metabolome

KW - Mitochondria

KW - Photosynthesis

KW - Protein Isoforms

KW - Signal Transduction

KW - Transcription Factors

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1016/j.bbabio.2016.03.017

DO - 10.1016/j.bbabio.2016.03.017

M3 - Journal article

C2 - 26997501

SN - 0005-2728

VL - 1857

SP - 1313

EP - 1325

JO - B B A - Bioenergetics

JF - B B A - Bioenergetics

IS - 8

Y2 - 2 July 2016 through 7 July 2016

ER -