Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding

Rasmus Ribel-Madsen; Charlotte Brøns; Martin Friedrichsen; Pernille Poulsen; Allan Vaag

doi:10.1038/oby.2010.311

Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding

Rasmus Ribel-Madsen, Charlotte Brøns, Martin Friedrichsen, Pernille Poulsen, Allan Vaag

3 Citations (Scopus)

Abstract

Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy X-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (Β = 0.9νg/ml (0.08;1.8) (95% confidence interval), P = 0.03) and plasma levels of low-density lipoprotein cholesterol (Β = 5.3νg/ml (1.9;8.7), P = 0.03) and triglycerides (Β = 15.4νg/ml (9.5;21.3), P 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D i) (Β = 2.4% (4.5%;0.2%), P = 0.04) and increased basal hepatic glucose production rate (HGP) (Β = 0.02mg kg 1 min 1 (0.002;0.04), P = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short-term high-fat diet-induced insulin resistance.

Original language	English
Journal	Obesity
Volume	19
Issue number	6
Pages (from-to)	1304-1306
Number of pages	3
ISSN	1930-7381
DOIs	https://doi.org/10.1038/oby.2010.311
Publication status	Published - 1 Jun 2011

Keywords

Adult
Birth Weight
Body Mass Index
Cholesterol, LDL
Cross-Over Studies
Dietary Fats
Glucose
Humans
Infant Nutrition Disorders
Infant, Low Birth Weight
Infant, Newborn
Insulin Resistance
Liver
Male
Metabolic Syndrome X
Overnutrition
Retinol-Binding Proteins, Plasma
Thinness
Triglycerides
Vitamin A
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

@article{8d928cdb447046f9ba81e44f575fa302,

title = "Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding",

abstract = "Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy X-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (Β = 0.9νg/ml (0.08;1.8) (95% confidence interval), P = 0.03) and plasma levels of low-density lipoprotein cholesterol (Β = 5.3νg/ml (1.9;8.7), P = 0.03) and triglycerides (Β = 15.4νg/ml (9.5;21.3), P 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D i) (Β = 2.4% (4.5%;0.2%), P = 0.04) and increased basal hepatic glucose production rate (HGP) (Β = 0.02mg kg 1 min 1 (0.002;0.04), P = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short-term high-fat diet-induced insulin resistance.",

keywords = "Adult, Birth Weight, Body Mass Index, Cholesterol, LDL, Cross-Over Studies, Dietary Fats, Glucose, Humans, Infant Nutrition Disorders, Infant, Low Birth Weight, Infant, Newborn, Insulin Resistance, Liver, Male, Metabolic Syndrome X, Overnutrition, Retinol-Binding Proteins, Plasma, Thinness, Triglycerides, Vitamin A, Young Adult",

author = "Rasmus Ribel-Madsen and Charlotte Br{\o}ns and Martin Friedrichsen and Pernille Poulsen and Allan Vaag",

year = "2011",

month = jun,

day = "1",

doi = "10.1038/oby.2010.311",

language = "English",

volume = "19",

pages = "1304--1306",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley-Blackwell",

number = "6",

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TY - JOUR

T1 - Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight

T2 - Physiological Response to Short-Term Overfeeding

AU - Ribel-Madsen, Rasmus

AU - Brøns, Charlotte

AU - Friedrichsen, Martin

AU - Poulsen, Pernille

AU - Vaag, Allan

PY - 2011/6/1

Y1 - 2011/6/1

N2 - Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy X-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (Β = 0.9νg/ml (0.08;1.8) (95% confidence interval), P = 0.03) and plasma levels of low-density lipoprotein cholesterol (Β = 5.3νg/ml (1.9;8.7), P = 0.03) and triglycerides (Β = 15.4νg/ml (9.5;21.3), P 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D i) (Β = 2.4% (4.5%;0.2%), P = 0.04) and increased basal hepatic glucose production rate (HGP) (Β = 0.02mg kg 1 min 1 (0.002;0.04), P = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short-term high-fat diet-induced insulin resistance.

AB - Retinol-binding protein 4 (RBP4) is a plasma protein which is elevated in obesity and type 2 diabetes. We aimed to investigate whether RBP4 represents a mechanism underlying the associations between low birth weight (LBW), high-fat diet, and insulin resistance. Forty-six young, lean men with low (n = 20) or normal (n = 26) birth weight underwent a 5-day high-fat high-calorie (HFHC) dietary intervention. In vivo glucose metabolism was assessed by euglycemic-hyperinsulinemic clamp, glucose tracer and intravenous glucose tolerance test techniques. Body composition was measured by a dual-energy X-ray absorptiometry scan, and plasma RBP4 by an enzyme-linked immunosorbent assay. RBP4 was not associated with birth weight, but with BMI (Β = 0.9νg/ml (0.08;1.8) (95% confidence interval), P = 0.03) and plasma levels of low-density lipoprotein cholesterol (Β = 5.3νg/ml (1.9;8.7), P = 0.03) and triglycerides (Β = 15.4νg/ml (9.5;21.3), P 0.001). Under baseline diet conditions, RBP4 was associated with decreased disposition index (D i) (Β = 2.4% (4.5%;0.2%), P = 0.04) and increased basal hepatic glucose production rate (HGP) (Β = 0.02mg kg 1 min 1 (0.002;0.04), P = 0.03), but not associated with peripheral glucose disposal rate or hepatic insulin resistance index. RBP4 levels were not influenced by overfeeding or related to peripheral and hepatic insulin resistance provoked by the dietary intervention. In conclusion, plasma RBP4 in young men associates with components of the metabolic syndrome, but is not determined by birth weight and seems not to be involved in short-term high-fat diet-induced insulin resistance.

KW - Adult

KW - Birth Weight

KW - Body Mass Index

KW - Cholesterol, LDL

KW - Cross-Over Studies

KW - Dietary Fats

KW - Glucose

KW - Humans

KW - Infant Nutrition Disorders

KW - Infant, Low Birth Weight

KW - Infant, Newborn

KW - Insulin Resistance

KW - Liver

KW - Male

KW - Metabolic Syndrome X

KW - Overnutrition

KW - Retinol-Binding Proteins, Plasma

KW - Thinness

KW - Triglycerides

KW - Vitamin A

KW - Young Adult

U2 - 10.1038/oby.2010.311

DO - 10.1038/oby.2010.311

M3 - Journal article

C2 - 21164503

SN - 1930-7381

VL - 19

SP - 1304

EP - 1306

JO - Obesity

JF - Obesity

IS - 6

ER -

Retinol-Binding Protein 4 in Young Men With Low Versus Normal Birth Weight: Physiological Response to Short-Term Overfeeding

Abstract

Keywords

UN SDGs

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