Resting Heart Rate is a Predictor of Mortality in Chronic Obstructive Pulmonary Disease

Magnus T Jensen; Jacob Louis Marott; Peter Lange; Jørgen Vestbo; Peter Schnohr; Olav Wendelboe Nielsen; Jan Skov Jensen; Gorm Boje Jensen

doi:10.1183/09031936.00072212

Resting Heart Rate is a Predictor of Mortality in Chronic Obstructive Pulmonary Disease

Magnus T Jensen, Jacob Louis Marott, Peter Lange, Jørgen Vestbo, Peter Schnohr, Olav Wendelboe Nielsen, Jan Skov Jensen, Gorm Boje Jensen

Section of Social Medicine

70 Citations (Scopus)

Abstract

The clinical significance of high heart rate in COPD is unexplored.We investigated the association between resting heart rate (RHR), pulmonary function, and prognosis in subjects with COPD.16,696 subjects above 40 years from The Copenhagen City Heart Study, a prospective study of the general population, followed for 35.3 years, 10,986 deaths occurring. Analyses were performed using time-dependent Cox-models and net reclassification index (NRI).RHR increased with severity of COPD (p<0.001). RHR was associated with both cardiovascular and all-cause mortality across all stages of COPD (p<0.001).Within each stage of COPD, RHR improved the prediction of median life expectancy; the difference between <65 bpm and >85 bpm was 5.5 years in no COPD, 9.8 years in mild, 6.7 years in moderate, and 5.9 years in severe/very severe, (p<0.001). RHR significantly improved risk prediction when added to GOLD stage, (categorical NRI 4.9%, p=0.01; categoryless NRI 23.0%, p<0.0001), or FEV1 in percent of predicted (categorical NRI 7.8%, p=0.002; categoryless NRI 24.1%, p<0.0001).RHR increases with severity of COPD. RHR is a readily available clinical variable that improves risk prediction in patients with COPD above and beyond that of pulmonary function alone. RHR may be a potential target for intervention in COPD.

Original language	English
Journal	The European Respiratory Journal
Volume	42
Issue number	2
Pages (from-to)	341-349
DOIs	https://doi.org/10.1183/09031936.00072212
Publication status	Published - 8 Nov 2012

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10.1183/09031936.00072212

http://erj.ersjournals.com/content/42/2/341.long

Cite this

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title = "Resting Heart Rate is a Predictor of Mortality in Chronic Obstructive Pulmonary Disease",

abstract = "The clinical significance of high heart rate in COPD is unexplored.We investigated the association between resting heart rate (RHR), pulmonary function, and prognosis in subjects with COPD.16,696 subjects above 40 years from The Copenhagen City Heart Study, a prospective study of the general population, followed for 35.3 years, 10,986 deaths occurring. Analyses were performed using time-dependent Cox-models and net reclassification index (NRI).RHR increased with severity of COPD (p<0.001). RHR was associated with both cardiovascular and all-cause mortality across all stages of COPD (p<0.001).Within each stage of COPD, RHR improved the prediction of median life expectancy; the difference between <65 bpm and >85 bpm was 5.5 years in no COPD, 9.8 years in mild, 6.7 years in moderate, and 5.9 years in severe/very severe, (p<0.001). RHR significantly improved risk prediction when added to GOLD stage, (categorical NRI 4.9%, p=0.01; categoryless NRI 23.0%, p<0.0001), or FEV1 in percent of predicted (categorical NRI 7.8%, p=0.002; categoryless NRI 24.1%, p<0.0001).RHR increases with severity of COPD. RHR is a readily available clinical variable that improves risk prediction in patients with COPD above and beyond that of pulmonary function alone. RHR may be a potential target for intervention in COPD.",

author = "Jensen, {Magnus T} and Marott, {Jacob Louis} and Peter Lange and J{\o}rgen Vestbo and Peter Schnohr and Nielsen, {Olav Wendelboe} and Jensen, {Jan Skov} and Jensen, {Gorm Boje}",

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T1 - Resting Heart Rate is a Predictor of Mortality in Chronic Obstructive Pulmonary Disease

AU - Jensen, Magnus T

AU - Marott, Jacob Louis

AU - Lange, Peter

AU - Vestbo, Jørgen

AU - Schnohr, Peter

AU - Nielsen, Olav Wendelboe

AU - Jensen, Jan Skov

AU - Jensen, Gorm Boje

PY - 2012/11/8

Y1 - 2012/11/8

N2 - The clinical significance of high heart rate in COPD is unexplored.We investigated the association between resting heart rate (RHR), pulmonary function, and prognosis in subjects with COPD.16,696 subjects above 40 years from The Copenhagen City Heart Study, a prospective study of the general population, followed for 35.3 years, 10,986 deaths occurring. Analyses were performed using time-dependent Cox-models and net reclassification index (NRI).RHR increased with severity of COPD (p<0.001). RHR was associated with both cardiovascular and all-cause mortality across all stages of COPD (p<0.001).Within each stage of COPD, RHR improved the prediction of median life expectancy; the difference between <65 bpm and >85 bpm was 5.5 years in no COPD, 9.8 years in mild, 6.7 years in moderate, and 5.9 years in severe/very severe, (p<0.001). RHR significantly improved risk prediction when added to GOLD stage, (categorical NRI 4.9%, p=0.01; categoryless NRI 23.0%, p<0.0001), or FEV1 in percent of predicted (categorical NRI 7.8%, p=0.002; categoryless NRI 24.1%, p<0.0001).RHR increases with severity of COPD. RHR is a readily available clinical variable that improves risk prediction in patients with COPD above and beyond that of pulmonary function alone. RHR may be a potential target for intervention in COPD.

AB - The clinical significance of high heart rate in COPD is unexplored.We investigated the association between resting heart rate (RHR), pulmonary function, and prognosis in subjects with COPD.16,696 subjects above 40 years from The Copenhagen City Heart Study, a prospective study of the general population, followed for 35.3 years, 10,986 deaths occurring. Analyses were performed using time-dependent Cox-models and net reclassification index (NRI).RHR increased with severity of COPD (p<0.001). RHR was associated with both cardiovascular and all-cause mortality across all stages of COPD (p<0.001).Within each stage of COPD, RHR improved the prediction of median life expectancy; the difference between <65 bpm and >85 bpm was 5.5 years in no COPD, 9.8 years in mild, 6.7 years in moderate, and 5.9 years in severe/very severe, (p<0.001). RHR significantly improved risk prediction when added to GOLD stage, (categorical NRI 4.9%, p=0.01; categoryless NRI 23.0%, p<0.0001), or FEV1 in percent of predicted (categorical NRI 7.8%, p=0.002; categoryless NRI 24.1%, p<0.0001).RHR increases with severity of COPD. RHR is a readily available clinical variable that improves risk prediction in patients with COPD above and beyond that of pulmonary function alone. RHR may be a potential target for intervention in COPD.

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