Response inhibition is associated with white matter microstructure in children

Kathrine Skak Madsen; William F C Baaré; Martin Vestergaard; Arnold Skimminge; Lisser Rye Ejersbo; Thomas Z Ramsøy; Christian Gerlach; Per Akeson; Olaf B Paulson; Terry L Jernigan; Kathrine Skak Madsen; William Frans Christian Baaré; Martin Vestergaard Gøtzsche; Arnold Jesper Møller Skimminge; Lisser Rye Ejersbo; Thomas Ramsøy; Christian Gerlach; Per Åkeson; Olaf B Paulson; Terry L Jernigan

doi:10.1016/j.neuropsychologia.2009.11.001

Response inhibition is associated with white matter microstructure in children

Kathrine Skak Madsen, William F C Baaré, Martin Vestergaard, Arnold Skimminge, Lisser Rye Ejersbo, Thomas Z Ramsøy, Christian Gerlach, Per Akeson, Olaf B Paulson, Terry L Jernigan, Kathrine Skak Madsen, William Frans Christian Baaré, Martin Vestergaard Gøtzsche, Arnold Jesper Møller Skimminge, Lisser Rye Ejersbo, Thomas Ramsøy, Christian Gerlach, Per Åkeson, Olaf B Paulson, Terry L Jernigan

Department of Clinical Medicine

64 Citations (Scopus)

Abstract

Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.

Original language	English
Journal	Neuropsychologia
Volume	48
Issue number	4
Pages (from-to)	854-62
Number of pages	9
ISSN	0028-3932
DOIs	https://doi.org/10.1016/j.neuropsychologia.2009.11.001 https://doi.org/10.1016/j.neuropsychologia.2009.11.001
Publication status	Published - 1 Mar 2010

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Madsen, K. S., Baaré, W. F. C., Vestergaard, M., Skimminge, A., Ejersbo, L. R., Ramsøy, T. Z., Gerlach, C., Akeson, P., Paulson, O. B., Jernigan, T. L., Madsen, K. S., Baaré, W. F. C., Gøtzsche, M. V., Skimminge, A. J. M., Ejersbo, L. R., Ramsøy, T., Gerlach, C., Åkeson, P., Paulson, O. B., & Jernigan, T. L. (2010). Response inhibition is associated with white matter microstructure in children. Neuropsychologia, 48(4), 854-62. https://doi.org/10.1016/j.neuropsychologia.2009.11.001, https://doi.org/10.1016/j.neuropsychologia.2009.11.001

Madsen, KS, Baaré, WFC, Vestergaard, M, Skimminge, A, Ejersbo, LR, Ramsøy, TZ, Gerlach, C, Akeson, P, Paulson, OB, Jernigan, TL, Madsen, KS, Baaré, WFC, Gøtzsche, MV, Skimminge, AJM, Ejersbo, LR, Ramsøy, T, Gerlach, C, Åkeson, P, Paulson, OB & Jernigan, TL 2010, 'Response inhibition is associated with white matter microstructure in children', Neuropsychologia, vol. 48, no. 4, pp. 854-62. https://doi.org/10.1016/j.neuropsychologia.2009.11.001, https://doi.org/10.1016/j.neuropsychologia.2009.11.001

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title = "Response inhibition is associated with white matter microstructure in children",

abstract = "Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.",

author = "Madsen, {Kathrine Skak} and Baar{\'e}, {William F C} and Martin Vestergaard and Arnold Skimminge and Ejersbo, {Lisser Rye} and Rams{\o}y, {Thomas Z} and Christian Gerlach and Per Akeson and Paulson, {Olaf B} and Jernigan, {Terry L} and Madsen, {Kathrine Skak} and Baar{\'e}, {William Frans Christian} and G{\o}tzsche, {Martin Vestergaard} and Skimminge, {Arnold Jesper M{\o}ller} and Ejersbo, {Lisser Rye} and Thomas Rams{\o}y and Christian Gerlach and Per {\AA}keson and Paulson, {Olaf B} and Jernigan, {Terry L}",

note = "Keywords: Adolescent; Age Factors; Brain; Child; Female; Frontal Lobe; Functional Laterality; Humans; Image Processing, Computer-Assisted; Inhibition (Psychology); Linear Models; Magnetic Resonance Imaging; Male; Motor Cortex; Neural Pathways; Neuropsychological Tests; Psychomotor Performance; Reaction Time",

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T1 - Response inhibition is associated with white matter microstructure in children

AU - Madsen, Kathrine Skak

AU - Baaré, William F C

AU - Vestergaard, Martin

AU - Skimminge, Arnold

AU - Ejersbo, Lisser Rye

AU - Ramsøy, Thomas Z

AU - Gerlach, Christian

AU - Akeson, Per

AU - Paulson, Olaf B

AU - Jernigan, Terry L

AU - Madsen, Kathrine Skak

AU - Baaré, William Frans Christian

AU - Gøtzsche, Martin Vestergaard

AU - Skimminge, Arnold Jesper Møller

AU - Ejersbo, Lisser Rye

AU - Ramsøy, Thomas

AU - Gerlach, Christian

AU - Åkeson, Per

AU - Paulson, Olaf B

AU - Jernigan, Terry L

N1 - Keywords: Adolescent; Age Factors; Brain; Child; Female; Frontal Lobe; Functional Laterality; Humans; Image Processing, Computer-Assisted; Inhibition (Psychology); Linear Models; Magnetic Resonance Imaging; Male; Motor Cortex; Neural Pathways; Neuropsychological Tests; Psychomotor Performance; Reaction Time

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.

AB - Cognitive control of thoughts, actions and emotions is important for normal behaviour and the development of such control continues throughout childhood and adolescence. Several lines of evidence suggest that response inhibition is primarily mediated by a right-lateralized network involving inferior frontal gyrus (IFG), presupplementary motor cortex (preSMA), and subthalamic nucleus. Though the brain's fibre tracts are known to develop during childhood, little is known about how fibre tract development within this network relates to developing behavioural control. Here we examined the relationship between response inhibition, as measured with the stop-signal task, and indices of regional white matter microstructure in typically-developing children. We hypothesized that better response inhibition performance would be associated with higher fractional anisotropy (FA) in fibre tracts within right IFG and preSMA after controlling for age. Mean FA and diffusivity values were extracted from right and left IFG and preSMA. As hypothesized, faster response inhibition was significantly associated with higher FA and lower perpendicular diffusivity in both the right IFG and the right preSMA, possibly reflecting faster speed of neural conduction within more densely packed or better myelinated fibre tracts. Moreover, both of these effects remained significant after controlling for age and whole brain estimates of these DTI parameters. Interestingly, right IFG and preSMA FA contributed additively to the prediction of performance variability. Observed associations may be related to variation in phase of maturation, to activity-dependent alterations in the network subserving response inhibition, or to stable individual differences in underlying neural system connectivity.

U2 - 10.1016/j.neuropsychologia.2009.11.001

DO - 10.1016/j.neuropsychologia.2009.11.001

M3 - Journal article

SN - 0028-3932

VL - 48

SP - 854

EP - 862

JO - Neuropsychologia

JF - Neuropsychologia

IS - 4

ER -

Response inhibition is associated with white matter microstructure in children

Abstract

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