Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension

Christoffer Göransson; Niels Vejlstrup; Jørn Carlsen

doi:10.1007/s10554-017-1281-1

Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension

Christoffer Göransson, Niels Vejlstrup, Jørn Carlsen

Department of Clinical Medicine

4 Citations (Scopus)

Abstract

Right ventricular (RV) and left ventricular (LV) diastolic stiffness may be independent contributors to disease progression in pulmonary arterial hypertension (PAH). The aims of this study are to assess reproducibility of peak emptying rate (PER) and early diastolic peak filling rate (PFR) for both the RV and the LV in PAH and study their relationship to stroke volume (SV). Triple weekly repetition of 20 (totalling 60) cardiovascular magnetic resonance (CMR) scans, were done on 10 patients with PAH and 10 healthy controls. RV and LV volumes were measured over the full cardiac cycle. PER and PFR were calculated as the first derivative of the time–volume relationship in both the RV and the LV and indexed to body surface area. Reproducibility and the relation to SV were studied in a mixed model. PFR was lower in PAH in both the RV (PAH = 170 mL/m²/s, controls = 236 mL/m²/s [p < 0.01]) and in the LV (PAH = 209 mL/m²/s, controls = 311 mL/m²/s [p < 0.01]). PERs were not significantly different between patients and controls. Reproducibility of PER and PFR was high. A trial targeting normalization of PFR requires a total sample size of < 20. PER and PFR in both ventricles were strongly associated with stroke volume (all four: p < 0.01). Biventricular diastolic dysfunctions are strongly associated with stroke volume, and CMR can quantify them with high reproducibility, enabling small sample sizes for trials of therapies targeting diastolic dysfunction to increase survival.

Original language	English
Journal	International Journal of Cardiovascular Imaging
Volume	34
Issue number	5
Pages (from-to)	777-786
ISSN	1569-5794
DOIs	https://doi.org/10.1007/s10554-017-1281-1
Publication status	Published - 1 May 2018

Keywords

Adult
Arterial Pressure
Case-Control Studies
Diastole
Female
Humans
Hypertension, Pulmonary/complications
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Predictive Value of Tests
Pulmonary Artery/physiopathology
Reproducibility of Results
Systole
Ventricular Dysfunction, Left/diagnostic imaging
Ventricular Dysfunction, Right/diagnostic imaging
Ventricular Function, Left
Ventricular Function, Right

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Göransson, C., Vejlstrup, N., & Carlsen, J. (2018). Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension. International Journal of Cardiovascular Imaging, 34(5), 777-786. https://doi.org/10.1007/s10554-017-1281-1

Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension. / Göransson, Christoffer; Vejlstrup, Niels; Carlsen, Jørn.
In: International Journal of Cardiovascular Imaging, Vol. 34, No. 5, 01.05.2018, p. 777-786.

Research output: Contribution to journal › Journal article › Research › peer-review

Göransson, C, Vejlstrup, N & Carlsen, J 2018, 'Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension', International Journal of Cardiovascular Imaging, vol. 34, no. 5, pp. 777-786. https://doi.org/10.1007/s10554-017-1281-1

Göransson C, Vejlstrup N, Carlsen J. Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension. International Journal of Cardiovascular Imaging. 2018 May 1;34(5):777-786. doi: 10.1007/s10554-017-1281-1

Göransson, Christoffer ; Vejlstrup, Niels ; Carlsen, Jørn. / Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension. In: International Journal of Cardiovascular Imaging. 2018 ; Vol. 34, No. 5. pp. 777-786.

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title = "Reproducibility of peak filling and peak emptying rate determined by cardiovascular magnetic resonance imaging for assessment of biventricular systolic and diastolic dysfunction in patients with pulmonary arterial hypertension",

abstract = "Right ventricular (RV) and left ventricular (LV) diastolic stiffness may be independent contributors to disease progression in pulmonary arterial hypertension (PAH). The aims of this study are to assess reproducibility of peak emptying rate (PER) and early diastolic peak filling rate (PFR) for both the RV and the LV in PAH and study their relationship to stroke volume (SV). Triple weekly repetition of 20 (totalling 60) cardiovascular magnetic resonance (CMR) scans, were done on 10 patients with PAH and 10 healthy controls. RV and LV volumes were measured over the full cardiac cycle. PER and PFR were calculated as the first derivative of the time–volume relationship in both the RV and the LV and indexed to body surface area. Reproducibility and the relation to SV were studied in a mixed model. PFR was lower in PAH in both the RV (PAH = 170 mL/m2/s, controls = 236 mL/m2/s [p < 0.01]) and in the LV (PAH = 209 mL/m2/s, controls = 311 mL/m2/s [p < 0.01]). PERs were not significantly different between patients and controls. Reproducibility of PER and PFR was high. A trial targeting normalization of PFR requires a total sample size of < 20. PER and PFR in both ventricles were strongly associated with stroke volume (all four: p < 0.01). Biventricular diastolic dysfunctions are strongly associated with stroke volume, and CMR can quantify them with high reproducibility, enabling small sample sizes for trials of therapies targeting diastolic dysfunction to increase survival.",

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AB - Right ventricular (RV) and left ventricular (LV) diastolic stiffness may be independent contributors to disease progression in pulmonary arterial hypertension (PAH). The aims of this study are to assess reproducibility of peak emptying rate (PER) and early diastolic peak filling rate (PFR) for both the RV and the LV in PAH and study their relationship to stroke volume (SV). Triple weekly repetition of 20 (totalling 60) cardiovascular magnetic resonance (CMR) scans, were done on 10 patients with PAH and 10 healthy controls. RV and LV volumes were measured over the full cardiac cycle. PER and PFR were calculated as the first derivative of the time–volume relationship in both the RV and the LV and indexed to body surface area. Reproducibility and the relation to SV were studied in a mixed model. PFR was lower in PAH in both the RV (PAH = 170 mL/m2/s, controls = 236 mL/m2/s [p < 0.01]) and in the LV (PAH = 209 mL/m2/s, controls = 311 mL/m2/s [p < 0.01]). PERs were not significantly different between patients and controls. Reproducibility of PER and PFR was high. A trial targeting normalization of PFR requires a total sample size of < 20. PER and PFR in both ventricles were strongly associated with stroke volume (all four: p < 0.01). Biventricular diastolic dysfunctions are strongly associated with stroke volume, and CMR can quantify them with high reproducibility, enabling small sample sizes for trials of therapies targeting diastolic dysfunction to increase survival.

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KW - Arterial Pressure

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KW - Ventricular Dysfunction, Right/diagnostic imaging

KW - Ventricular Function, Left

KW - Ventricular Function, Right

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