Abstract
Flattening of the electrocardiographic T-wave has been associated with proarrhythmic risk. It has also been demonstrated that triangulation of the monophasic action potential (MAP) manifests on the ECG as a flattened Twave. In this study we investigate the effects of sertindole on the electrocardiographic T-wave using a recently developed ECG marker of T-wave flatness which is directly correlated with sertindole-induced triangulation of the MAP prior to Torsade de Pointes arrhythmia in dogs. The effect of sertindole on T-wave flatness was compared with the effects of moxifloxacin and placebo on the T-wave. Sertindole caused more flattening of the T-wave compared to moxifloxacin and placebo. Effect sizes also revealed that flattening of the T-wave after sertindole was a more prominent finding compared to QT interval prolongation. An electrocardiographic measurement linking MAP triangulation and T-wave flatness could potentially be used for cardiac safety assessment in drug trials along with other safety measures.
| Original language | English |
|---|---|
| Article number | 7043059 |
| Journal | Computing in Cardiology |
| Volume | 41 |
| Pages (from-to) | 381-384 |
| ISSN | 2325-8861 |
| Publication status | Published - 1 Jan 2014 |
| Event | 41st Computing in Cardiology Conference, CinC 2014 - Cambridge, United States Duration: 7 Sept 2014 → 10 Sept 2014 |
Conference
| Conference | 41st Computing in Cardiology Conference, CinC 2014 |
|---|---|
| Country/Territory | United States |
| City | Cambridge |
| Period | 07/09/2014 → 10/09/2014 |
| Sponsor | et al., IEEE/EMBS, Massachusetts Institute of Technology, Mortara, Philips, PhysioNet |