Renal Aquaporins in Health and Disease

Marleen L.A. Kortenoeven; Emma Tina Bisgaard Olesen; Robert A. Fenton

Renal Aquaporins in Health and Disease

Marleen L.A. Kortenoeven, Emma Tina Bisgaard Olesen, Robert A. Fenton

Abstract

Aquaporins (AQPs) are a large family of membrane proteins that act as semipermeable channels. The majority of AQPs are permeable to water, but a subset of the family can also transport glycerol, urea, and other small solutes. Currently, 13 AQP homologues have been identified in mammals, termed AQP0–12. These aquaporins are highly abundant in epithelial cells and non-epithelial cells in various tissues including the kidney, brain, liver, lungs, and salivary glands. In this chapter we focus on AQPs expressed in kidney epithelial cells. We summarize the current knowledge with respect to their localization and function within the kidney tubule and their critical role in mammalian water homeostasis. We describe a number of water balance disorders resulting from altered AQP function and provide an overview of some of the treatment strategies for these disorders.

Original language	English
Title of host publication	Ion Channels and Transporters of Epithelia in Health and Disease
Number of pages	52
Publisher	Springer
Publication date	2016
Pages	803-854
Chapter	25
ISBN (Print)	978-1-4939-3364-8
ISBN (Electronic)	978-1-4939-3366-2
Publication status	Published - 2016
Externally published	Yes

Series	Physiology in Health and Disease

Cite this

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title = "Renal Aquaporins in Health and Disease",

abstract = "Aquaporins (AQPs) are a large family of membrane proteins that act as semipermeable channels. The majority of AQPs are permeable to water, but a subset of the family can also transport glycerol, urea, and other small solutes. Currently, 13 AQP homologues have been identified in mammals, termed AQP0–12. These aquaporins are highly abundant in epithelial cells and non-epithelial cells in various tissues including the kidney, brain, liver, lungs, and salivary glands. In this chapter we focus on AQPs expressed in kidney epithelial cells. We summarize the current knowledge with respect to their localization and function within the kidney tubule and their critical role in mammalian water homeostasis. We describe a number of water balance disorders resulting from altered AQP function and provide an overview of some of the treatment strategies for these disorders.",

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T1 - Renal Aquaporins in Health and Disease

AU - Kortenoeven, Marleen L.A.

AU - Olesen, Emma Tina Bisgaard

AU - Fenton, Robert A.

PY - 2016

Y1 - 2016

N2 - Aquaporins (AQPs) are a large family of membrane proteins that act as semipermeable channels. The majority of AQPs are permeable to water, but a subset of the family can also transport glycerol, urea, and other small solutes. Currently, 13 AQP homologues have been identified in mammals, termed AQP0–12. These aquaporins are highly abundant in epithelial cells and non-epithelial cells in various tissues including the kidney, brain, liver, lungs, and salivary glands. In this chapter we focus on AQPs expressed in kidney epithelial cells. We summarize the current knowledge with respect to their localization and function within the kidney tubule and their critical role in mammalian water homeostasis. We describe a number of water balance disorders resulting from altered AQP function and provide an overview of some of the treatment strategies for these disorders.

AB - Aquaporins (AQPs) are a large family of membrane proteins that act as semipermeable channels. The majority of AQPs are permeable to water, but a subset of the family can also transport glycerol, urea, and other small solutes. Currently, 13 AQP homologues have been identified in mammals, termed AQP0–12. These aquaporins are highly abundant in epithelial cells and non-epithelial cells in various tissues including the kidney, brain, liver, lungs, and salivary glands. In this chapter we focus on AQPs expressed in kidney epithelial cells. We summarize the current knowledge with respect to their localization and function within the kidney tubule and their critical role in mammalian water homeostasis. We describe a number of water balance disorders resulting from altered AQP function and provide an overview of some of the treatment strategies for these disorders.

M3 - Book chapter

SN - 978-1-4939-3364-8

T3 - Physiology in Health and Disease

SP - 803

EP - 854

BT - Ion Channels and Transporters of Epithelia in Health and Disease

PB - Springer

ER -