Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

Tuulikki Sokka; Merete Lund Hetland; Heidi Mäkinen; Hannu Kautiainen; Kim Hørslev-Petersen; Reijo K Luukkainen; Bernard Combe; Humeira Badsha; Alexandros A Drosos; Joe Devlin; Gianfranco Ferraccioli; Alessia Morelli; Monique Hoekstra; Maria Majdan; Stefan Sadkiewicz; Miguel Belmonte; Ann-Carin Holmqvist; Ernest Choy; Gerd R Burmester; Recep Tunc; Aleksander Dimic; Jovan Nedovic; Aleksandra Stankovic; Martin Bergman; Sergio Toloza; Theodore Pincus; NN NN; Aleksander Dimić; Jovan Nedović; Aleksandra Stanković

doi:http://dx.doi.org/10.1002/art.23794

Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

Tuulikki Sokka, Merete Lund Hetland, Heidi Mäkinen, Hannu Kautiainen, Kim Hørslev-Petersen, Reijo K Luukkainen, Bernard Combe, Humeira Badsha, Alexandros A Drosos, Joe Devlin, Gianfranco Ferraccioli, Alessia Morelli, Monique Hoekstra, Maria Majdan, Stefan Sadkiewicz, Miguel Belmonte, Ann-Carin Holmqvist, Ernest Choy, Gerd R Burmester, Recep TuncAleksander Dimic, Jovan Nedovic, Aleksandra Stankovic, Martin Bergman, Sergio Toloza, Theodore Pincus, NN NN, Aleksander Dimić, Jovan Nedović, Aleksandra Stanković

Department of Clinical Medicine

130 Citations (Scopus)

Abstract

OBJECTIVE: To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). METHODS: The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). RESULTS: The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was >/=15% in 10 countries, 5-14% in 7 countries, and <5% in 7 countries (the latter of which had generally low remission rates [<5.5%]). Regardless of the definition of remission, male sex, higher education, shorter disease duration, smaller number of comorbidities, and regular exercise were statistically significantly associated with remission. CONCLUSION: The use of different definitions of RA remission leads to different results with regard to remission rates, with considerable variation among countries and between sexes. Reported remission rates in clinical trials and clinical studies have to be interpreted in light of the definition of remission that has been used.

Original language	English
Journal	Arthritis & Rheumatism
Volume	58
Issue number	9
Pages (from-to)	2642-51
Number of pages	9
ISSN	0004-3591
DOIs	https://doi.org/10.1002/art.23794
Publication status	Published - 2008

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Sokka, T., Hetland, M. L., Mäkinen, H., Kautiainen, H., Hørslev-Petersen, K., Luukkainen, R. K., Combe, B., Badsha, H., Drosos, A. A., Devlin, J., Ferraccioli, G., Morelli, A., Hoekstra, M., Majdan, M., Sadkiewicz, S., Belmonte, M., Holmqvist, A-C., Choy, E., Burmester, G. R., ... Stanković, A. (2008). Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries. Arthritis & Rheumatism, 58(9), 2642-51. https://doi.org/10.1002/art.23794

Sokka, T, Hetland, ML, Mäkinen, H, Kautiainen, H, Hørslev-Petersen, K, Luukkainen, RK, Combe, B, Badsha, H, Drosos, AA, Devlin, J, Ferraccioli, G, Morelli, A, Hoekstra, M, Majdan, M, Sadkiewicz, S, Belmonte, M, Holmqvist, A-C, Choy, E, Burmester, GR, Tunc, R, Dimic, A, Nedovic, J, Stankovic, A, Bergman, M, Toloza, S, Pincus, T, NN, NN, Dimić, A, Nedović, J & Stanković, A 2008, 'Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries', Arthritis & Rheumatism, vol. 58, no. 9, pp. 2642-51. https://doi.org/10.1002/art.23794

@article{8b9df278d8104a1da91a6b6cd5299e4c,

title = "Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries",

abstract = "OBJECTIVE: To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). METHODS: The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). RESULTS: The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was >/=15% in 10 countries, 5-14% in 7 countries, and <5% in 7 countries (the latter of which had generally low remission rates [<5.5%]). Regardless of the definition of remission, male sex, higher education, shorter disease duration, smaller number of comorbidities, and regular exercise were statistically significantly associated with remission. CONCLUSION: The use of different definitions of RA remission leads to different results with regard to remission rates, with considerable variation among countries and between sexes. Reported remission rates in clinical trials and clinical studies have to be interpreted in light of the definition of remission that has been used.",

author = "Tuulikki Sokka and Hetland, {Merete Lund} and Heidi M{\"a}kinen and Hannu Kautiainen and Kim H{\o}rslev-Petersen and Luukkainen, {Reijo K} and Bernard Combe and Humeira Badsha and Drosos, {Alexandros A} and Joe Devlin and Gianfranco Ferraccioli and Alessia Morelli and Monique Hoekstra and Maria Majdan and Stefan Sadkiewicz and Miguel Belmonte and Ann-Carin Holmqvist and Ernest Choy and Burmester, {Gerd R} and Recep Tunc and Aleksander Dimic and Jovan Nedovic and Aleksandra Stankovic and Martin Bergman and Sergio Toloza and Theodore Pincus and NN NN and Aleksander Dimi{\'c} and Jovan Nedovi{\'c} and Aleksandra Stankovi{\'c}",

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doi = "http://dx.doi.org/10.1002/art.23794",

language = "English",

volume = "58",

pages = "2642--51",

journal = "Arthritis & Rheumatology",

issn = "2326-5205",

publisher = "Wiley",

number = "9",

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TY - JOUR

T1 - Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

AU - Sokka, Tuulikki

AU - Hetland, Merete Lund

AU - Mäkinen, Heidi

AU - Kautiainen, Hannu

AU - Hørslev-Petersen, Kim

AU - Luukkainen, Reijo K

AU - Combe, Bernard

AU - Badsha, Humeira

AU - Drosos, Alexandros A

AU - Devlin, Joe

AU - Ferraccioli, Gianfranco

AU - Morelli, Alessia

AU - Hoekstra, Monique

AU - Majdan, Maria

AU - Sadkiewicz, Stefan

AU - Belmonte, Miguel

AU - Holmqvist, Ann-Carin

AU - Choy, Ernest

AU - Burmester, Gerd R

AU - Tunc, Recep

AU - Dimic, Aleksander

AU - Nedovic, Jovan

AU - Stankovic, Aleksandra

AU - Bergman, Martin

AU - Toloza, Sergio

AU - Pincus, Theodore

AU - NN, NN

AU - Dimić, Aleksander

AU - Nedović, Jovan

AU - Stanković, Aleksandra

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). METHODS: The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). RESULTS: The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was >/=15% in 10 countries, 5-14% in 7 countries, and <5% in 7 countries (the latter of which had generally low remission rates [<5.5%]). Regardless of the definition of remission, male sex, higher education, shorter disease duration, smaller number of comorbidities, and regular exercise were statistically significantly associated with remission. CONCLUSION: The use of different definitions of RA remission leads to different results with regard to remission rates, with considerable variation among countries and between sexes. Reported remission rates in clinical trials and clinical studies have to be interpreted in light of the definition of remission that has been used.

AB - OBJECTIVE: To compare the performance of different definitions of remission in a large multinational cross-sectional cohort of patients with rheumatoid arthritis (RA). METHODS: The Questionnaires in Standard Monitoring of Patients with RA (QUEST-RA) database, which (as of January 2008) included 5,848 patients receiving usual care at 67 sites in 24 countries, was used for this study. Patients were clinically assessed by rheumatologists and completed a 4-page self-report questionnaire. The database was analyzed according to the following definitions of remission: American College of Rheumatology (ACR) definition, Disease Activity Score in 28 joints (DAS28), Clinical Disease Activity Index (CDAI), clinical remission assessed using 42 and 28 joints (Clin42 and Clin28), patient self-report Routine Assessment of Patient Index Data 3 (RAPID3), and physician report of no disease activity (MD remission). RESULTS: The overall remission rate was lowest using the ACR definition of remission (8.6%), followed by the Clin42 (10.6%), Clin28 (12.6%), CDAI (13.8%), MD remission (14.2%), and RAPID3 (14.3%); the rate of remission was highest when remission was defined using the DAS28 (19.6%). The difference between the highest and lowest remission rates was >/=15% in 10 countries, 5-14% in 7 countries, and <5% in 7 countries (the latter of which had generally low remission rates [<5.5%]). Regardless of the definition of remission, male sex, higher education, shorter disease duration, smaller number of comorbidities, and regular exercise were statistically significantly associated with remission. CONCLUSION: The use of different definitions of RA remission leads to different results with regard to remission rates, with considerable variation among countries and between sexes. Reported remission rates in clinical trials and clinical studies have to be interpreted in light of the definition of remission that has been used.

U2 - http://dx.doi.org/10.1002/art.23794

DO - http://dx.doi.org/10.1002/art.23794

M3 - Journal article

SN - 2326-5205

VL - 58

SP - 2642

EP - 2651

JO - Arthritis & Rheumatology

JF - Arthritis & Rheumatology

IS - 9

ER -

Remission and rheumatoid arthritis: Data on patients receiving usual care in twenty-four countries

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