Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression.

TY - JOUR

T1 - Relationship between local changes in cortical blood flow and extracellular K+ during spreading depression.

AU - Hansen, A J

AU - Quistorff, B

AU - Gjedde, A

PY - 1980

Y1 - 1980

N2 - Change of local cerebral blood flow in response to a single cortical spreading depression of Leão was studied in the brain. During a spreading depression, potassium briefly accumulates in the brain extracellular space. The cortical blood flow was normal during the maximal rate of increase of the extracellular potassium concentration. The blood flow doubled during the subsequent period of normalization of potassium and remained high for one minute thereafter. Thus, potassium cannot be the immediate mediator of the blood flow increase.

AB - Change of local cerebral blood flow in response to a single cortical spreading depression of Leão was studied in the brain. During a spreading depression, potassium briefly accumulates in the brain extracellular space. The cortical blood flow was normal during the maximal rate of increase of the extracellular potassium concentration. The blood flow doubled during the subsequent period of normalization of potassium and remained high for one minute thereafter. Thus, potassium cannot be the immediate mediator of the blood flow increase.

M3 - Journal article

C2 - 7446156

SN - 0302-2994

VL - 109

SP - 1

EP - 6

JO - Acta Physiologica Scandinavica, Supplement

JF - Acta Physiologica Scandinavica, Supplement

IS - 1

ER -