Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected individuals

TY - JOUR

T1 - Relationship between inflammatory and coagulation biomarkers and cardiac autonomic function in HIV-infected individuals

AU - Young, Lari C

AU - Roediger, Mollie P

AU - Grandits, Greg

AU - Baker, Jason

AU - Somboonwit, Charurut

AU - Williams, Ian

AU - Lundgren, Jens D

AU - Neaton, James D

AU - Soliman, Elsayed Z

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Aim: To examine the relationship between inflammatory and coagulation biomarkers and cardiac autonomic function (CAF) as measured by heart rate variability in persons with HIV. Materials & methods: This analysis included 4073 HIV-infected persons from the Strategies for Management of Antiretroviral Therapy study. We examined the association between IL-6, high-sensitivity C-reactive protein (hsCRP) and d -dimer with heart rate variability measures (SDNN and rMSSD), both cross-sectionally and longitudinally. Results: Cross-sectional analysis revealed significant inverse associations between IL-6, hsCRP and d -dimer with SDNN and rMSSD (p < 0.01 for all comparisons). However, longitudinal analysis failed to show a significant association between baseline IL-6, hsCRP and d -dimer with change in CAF over time. Conclusion: Cross-sectionally, higher levels of inflammatory and coagulation biomarkers were associated with lower levels of CAF in the Strategies for Management of Antiretroviral Therapy trial. Although deterioration in CAF was observed during followup, baseline levels of inflammatory and coagulation markers were not predictive of the decline in CAF over time.

AB - Aim: To examine the relationship between inflammatory and coagulation biomarkers and cardiac autonomic function (CAF) as measured by heart rate variability in persons with HIV. Materials & methods: This analysis included 4073 HIV-infected persons from the Strategies for Management of Antiretroviral Therapy study. We examined the association between IL-6, high-sensitivity C-reactive protein (hsCRP) and d -dimer with heart rate variability measures (SDNN and rMSSD), both cross-sectionally and longitudinally. Results: Cross-sectional analysis revealed significant inverse associations between IL-6, hsCRP and d -dimer with SDNN and rMSSD (p < 0.01 for all comparisons). However, longitudinal analysis failed to show a significant association between baseline IL-6, hsCRP and d -dimer with change in CAF over time. Conclusion: Cross-sectionally, higher levels of inflammatory and coagulation biomarkers were associated with lower levels of CAF in the Strategies for Management of Antiretroviral Therapy trial. Although deterioration in CAF was observed during followup, baseline levels of inflammatory and coagulation markers were not predictive of the decline in CAF over time.

U2 - 10.2217/bmm.14.27

DO - 10.2217/bmm.14.27

M3 - Journal article

C2 - 25402578

SN - 1752-0363

VL - 8

SP - 1073

EP - 1083

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 9

ER -