Regulation of taurine transport systems by protein kinase CK2 in mammalian cells

Ian Henry Lambert; Daniel Bloch Hansen

doi:10.1159/000335846

Regulation of taurine transport systems by protein kinase CK2 in mammalian cells

22 Citations (Scopus)

Abstract

Maintaining cell volume is critical for cellular function yet shift in cell volume is a prerequisite for mitosis and apoptosis. The ubiquitously and evolutionary conserved serine/threonine kinase CK2 promotes cell survival and suppresses apoptosis. The present review describes how mammalian cells regulate the cellular content of the major cellular organic osmolyte, taurine with emphasis on CK2 mediated regulation of active taurine uptake and volume-sensitive taurine release. Furthermore, we discuss how CK2-mediated regulation of taurine homeostasis is potentially involved in cellular functions such as proliferation and survival.

Original language	English
Journal	Cellular Physiology and Biochemistry
Volume	28
Issue number	6
Pages (from-to)	1099-1110
Number of pages	12
ISSN	1015-8987
DOIs	https://doi.org/10.1159/000335846
Publication status	Published - 2011

Keywords

Animals
Casein Kinase II
Cell Size
Glycogen Synthase Kinase 3
Membrane Glycoproteins
Membrane Transport Proteins
PTEN Phosphohydrolase
Phosphatidylinositol 3-Kinases
Reactive Oxygen Species
Taurine

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title = "Regulation of taurine transport systems by protein kinase CK2 in mammalian cells",

abstract = "Maintaining cell volume is critical for cellular function yet shift in cell volume is a prerequisite for mitosis and apoptosis. The ubiquitously and evolutionary conserved serine/threonine kinase CK2 promotes cell survival and suppresses apoptosis. The present review describes how mammalian cells regulate the cellular content of the major cellular organic osmolyte, taurine with emphasis on CK2 mediated regulation of active taurine uptake and volume-sensitive taurine release. Furthermore, we discuss how CK2-mediated regulation of taurine homeostasis is potentially involved in cellular functions such as proliferation and survival.",

keywords = "Animals, Casein Kinase II, Cell Size, Glycogen Synthase Kinase 3, Membrane Glycoproteins, Membrane Transport Proteins, PTEN Phosphohydrolase, Phosphatidylinositol 3-Kinases, Reactive Oxygen Species, Taurine",

author = "Lambert, {Ian Henry} and Hansen, {Daniel Bloch}",

note = "Copyright {\textcopyright} 2011 S. Karger AG, Basel.",

year = "2011",

doi = "10.1159/000335846",

language = "English",

volume = "28",

pages = "1099--1110",

journal = "Cellular Physiology and Biochemistry",

issn = "1015-8987",

publisher = "S Karger AG",

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T1 - Regulation of taurine transport systems by protein kinase CK2 in mammalian cells

AU - Lambert, Ian Henry

AU - Hansen, Daniel Bloch

PY - 2011

Y1 - 2011

N2 - Maintaining cell volume is critical for cellular function yet shift in cell volume is a prerequisite for mitosis and apoptosis. The ubiquitously and evolutionary conserved serine/threonine kinase CK2 promotes cell survival and suppresses apoptosis. The present review describes how mammalian cells regulate the cellular content of the major cellular organic osmolyte, taurine with emphasis on CK2 mediated regulation of active taurine uptake and volume-sensitive taurine release. Furthermore, we discuss how CK2-mediated regulation of taurine homeostasis is potentially involved in cellular functions such as proliferation and survival.

AB - Maintaining cell volume is critical for cellular function yet shift in cell volume is a prerequisite for mitosis and apoptosis. The ubiquitously and evolutionary conserved serine/threonine kinase CK2 promotes cell survival and suppresses apoptosis. The present review describes how mammalian cells regulate the cellular content of the major cellular organic osmolyte, taurine with emphasis on CK2 mediated regulation of active taurine uptake and volume-sensitive taurine release. Furthermore, we discuss how CK2-mediated regulation of taurine homeostasis is potentially involved in cellular functions such as proliferation and survival.

KW - Animals

KW - Casein Kinase II

KW - Cell Size

KW - Glycogen Synthase Kinase 3

KW - Membrane Glycoproteins

KW - Membrane Transport Proteins

KW - PTEN Phosphohydrolase

KW - Phosphatidylinositol 3-Kinases

KW - Reactive Oxygen Species

KW - Taurine

U2 - 10.1159/000335846

DO - 10.1159/000335846

M3 - Review

C2 - 22178999

SN - 1015-8987

VL - 28

SP - 1099

EP - 1110

JO - Cellular Physiology and Biochemistry

JF - Cellular Physiology and Biochemistry

IS - 6

ER -

Regulation of taurine transport systems by protein kinase CK2 in mammalian cells

Abstract

Keywords

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