Regulation of skeletal muscle blood flow during exercise

Lasse Gliemann; Camilla Vestergaard Hansen; Nicolai Rytter Mortensen; Ylva Hellsten

doi:10.1016/j.cophys.2019.05.001

Regulation of skeletal muscle blood flow during exercise

Lasse Gliemann, Camilla Vestergaard Hansen, Nicolai Rytter Mortensen, Ylva Hellsten^*

^*Corresponding author for this work

The August Krogh Section for Human Physiology

5 Citations (Scopus)

Abstract

A number of mechanisms govern the rapid and precise changes in blood flow which occur in skeletal muscle with alterations in metabolic demand. Such mechanisms include sympathetic activity, functional sympatholysis, conducted vasodilation, flow mediated dilation, and compounds which stimulate formation of endothelium derived vasodilators. Compounds identified to be of importance in vasodilation include nitric oxide, prostacyclin, potassium, and nucleotides. In this review, we briefly describe some of the basic mechanisms and present selected contemporary contributions to the field. The main focus is on basic regulation of exercise hyperemia but aspects of training, age and sex have also been included.

Original language	English
Journal	Current Opinion in Physiology
Volume	10
Pages (from-to)	146-155
Number of pages	10
ISSN	2468-8681
DOIs	https://doi.org/10.1016/j.cophys.2019.05.001
Publication status	Published - 2019

Keywords

Faculty of Science
Exercise hyperemia
Oxygen demand
Vasodilator mechanisms
Vascular function
Reactive oxygen species
Exercise training

Access to Document

10.1016/j.cophys.2019.05.001

Cite this

@article{f5d3aecdcbc8436d89cf6d2a9477629f,

title = "Regulation of skeletal muscle blood flow during exercise",

abstract = "A number of mechanisms govern the rapid and precise changes in blood flow which occur in skeletal muscle with alterations in metabolic demand. Such mechanisms include sympathetic activity, functional sympatholysis, conducted vasodilation, flow mediated dilation, and compounds which stimulate formation of endothelium derived vasodilators. Compounds identified to be of importance in vasodilation include nitric oxide, prostacyclin, potassium, and nucleotides. In this review, we briefly describe some of the basic mechanisms and present selected contemporary contributions to the field. The main focus is on basic regulation of exercise hyperemia but aspects of training, age and sex have also been included.",

keywords = "Faculty of Science, Exercise hyperemia, Oxygen demand, Vasodilator mechanisms, Vascular function, Reactive oxygen species, Exercise training",

author = "Lasse Gliemann and Hansen, {Camilla Vestergaard} and {Rytter Mortensen}, Nicolai and Ylva Hellsten",

note = "CURIS 2019 NEXS 285",

year = "2019",

doi = "10.1016/j.cophys.2019.05.001",

language = "English",

volume = "10",

pages = "146--155",

journal = "Current Opinion in Physiology",

issn = "2468-8681",

publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Regulation of skeletal muscle blood flow during exercise

AU - Gliemann, Lasse

AU - Hansen, Camilla Vestergaard

AU - Rytter Mortensen, Nicolai

AU - Hellsten, Ylva

N1 - CURIS 2019 NEXS 285

PY - 2019

Y1 - 2019

N2 - A number of mechanisms govern the rapid and precise changes in blood flow which occur in skeletal muscle with alterations in metabolic demand. Such mechanisms include sympathetic activity, functional sympatholysis, conducted vasodilation, flow mediated dilation, and compounds which stimulate formation of endothelium derived vasodilators. Compounds identified to be of importance in vasodilation include nitric oxide, prostacyclin, potassium, and nucleotides. In this review, we briefly describe some of the basic mechanisms and present selected contemporary contributions to the field. The main focus is on basic regulation of exercise hyperemia but aspects of training, age and sex have also been included.

AB - A number of mechanisms govern the rapid and precise changes in blood flow which occur in skeletal muscle with alterations in metabolic demand. Such mechanisms include sympathetic activity, functional sympatholysis, conducted vasodilation, flow mediated dilation, and compounds which stimulate formation of endothelium derived vasodilators. Compounds identified to be of importance in vasodilation include nitric oxide, prostacyclin, potassium, and nucleotides. In this review, we briefly describe some of the basic mechanisms and present selected contemporary contributions to the field. The main focus is on basic regulation of exercise hyperemia but aspects of training, age and sex have also been included.

KW - Faculty of Science

KW - Exercise hyperemia

KW - Oxygen demand

KW - Vasodilator mechanisms

KW - Vascular function

KW - Reactive oxygen species

KW - Exercise training

UR - http://www.scopus.com/inward/record.url?scp=85067563755&partnerID=8YFLogxK

U2 - 10.1016/j.cophys.2019.05.001

DO - 10.1016/j.cophys.2019.05.001

M3 - Review

AN - SCOPUS:85067563755

SN - 2468-8681

VL - 10

SP - 146

EP - 155

JO - Current Opinion in Physiology

JF - Current Opinion in Physiology

ER -

Regulation of skeletal muscle blood flow during exercise

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this