Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.

TY - JOUR

T1 - Regulation of mitogen-activated protein kinase pathways by the plasma membrane Na+/H+ exchanger, NHE1.

AU - Pedersen, Stine Helene Falsig

AU - Darborg, Barbara Vasek

AU - Rentsch, Maria Louise

AU - Rasmussen, Maria

N1 - Keywords: Cell Membrane; Extracellular Signal-Regulated MAP Kinases; MAP Kinase Signaling System; Models, Biological; Sodium-Hydrogen Antiporter

PY - 2006

Y1 - 2006

N2 - The mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK, play a major role in the regulation of pivotal cellular processes such as cell death/survival balance, cell cycle progression, and cell migration. MAPK activity is regulated by a three-tiered phosphorelay system, which is in turn regulated by a complex network of signaling events and scaffolding proteins. The ubiquitous plasma membrane Na(+)/H(+) exchanger NHE1 is activated by, and implicated in, the physiological/pathophysiological responses to many of the same stimuli that modulate MAPK activity. While under some conditions, NHE1 is regulated by MAPKs, a number of studies have, conversely, implicated NHE1 in the regulation of MAPK activity. Here, we discuss the current evidence indicating the involvement of NHE1 in MAPK regulation, the mechanisms by which this may occur, and the possible physiological and pathophysiological relevance of this phenomenon.

AB - The mitogen-activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38 MAPK, play a major role in the regulation of pivotal cellular processes such as cell death/survival balance, cell cycle progression, and cell migration. MAPK activity is regulated by a three-tiered phosphorelay system, which is in turn regulated by a complex network of signaling events and scaffolding proteins. The ubiquitous plasma membrane Na(+)/H(+) exchanger NHE1 is activated by, and implicated in, the physiological/pathophysiological responses to many of the same stimuli that modulate MAPK activity. While under some conditions, NHE1 is regulated by MAPKs, a number of studies have, conversely, implicated NHE1 in the regulation of MAPK activity. Here, we discuss the current evidence indicating the involvement of NHE1 in MAPK regulation, the mechanisms by which this may occur, and the possible physiological and pathophysiological relevance of this phenomenon.

U2 - 10.1016/j.abb.2006.12.001

DO - 10.1016/j.abb.2006.12.001

M3 - Journal article

C2 - 17321481

SN - 0003-9861

VL - 462

SP - 195

EP - 201

JO - Archives of Biochemistry and Biophysics

JF - Archives of Biochemistry and Biophysics

IS - 2

ER -