Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

TY - JOUR

T1 - Regulation and control of nitric oxide (NO) in macrophages

T2 - Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

AU - Kovacevic, Zaklina

AU - Sahni, Sumit

AU - Lok, K.H.

AU - Davies, M J

AU - Wink, D A

AU - Richardson, Des R

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MØs, to tumor cell targets.

AB - We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-MØ) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly-regulated species in M1-MØs. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-MØs, to tumor cell targets.

KW - Journal Article

KW - Review

U2 - 10.1016/j.bbagen.2017.02.021

DO - 10.1016/j.bbagen.2017.02.021

M3 - Review

C2 - 28219722

SN - 0304-419X

VL - 1861

SP - 995

EP - 999

JO - Biochimica et Biophysica Acta - Reviews on Cancer

JF - Biochimica et Biophysica Acta - Reviews on Cancer

IS - 5 Pt A

ER -