Regional tumour glutamine supply affects chromatin and cell identity

Jonas W Højfeldt; Kristian Helin

doi:10.1038/ncb3414

Regional tumour glutamine supply affects chromatin and cell identity

Jonas W Højfeldt, Kristian Helin

The Danish Stem Cell Center

2 Citations (Scopus)

Abstract

Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.

Original language	English
Journal	Nature Cell Biology
Volume	18
Issue number	10
Pages (from-to)	1027-9
Number of pages	3
ISSN	1465-7392
DOIs	https://doi.org/10.1038/ncb3414
Publication status	Published - 28 Sept 2016

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AB - Limited perfusion of solid tumours produces a nutrient-deprived tumour core microenvironment. Low glutamine levels in the tumour core are now shown to lead to reduced levels of α-ketoglutarate and decreased histone demethylase activity, thereby promoting a less differentiated and more therapy-resistant state of the tumour cells.

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Regional tumour glutamine supply affects chromatin and cell identity

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